Cortical synaptic mechanism for chronic pain and anxiety in Parkinson’s disease

Zhou, Zhaoxiang; Chen, Qiyu; Liu, Qin; Xu, Pingyi; Lu, Jing-Shan; Zhuo, Min

doi:10.2478/jtim-2022-0046

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…For example, brain regions involved in pain processing, such as the anterior cingulate cortex, insula, and amygdala, are also implicated in emotional regulation and the experience of emotions. [ 13 , 14 , 15 ] There is a suggestion that there might be shared neural circuitry between chronic pain and depression, and certain neurophysiological characteristics within tshis circuitry could define a specific subtype of depression that is more prone to developing comorbid pain and more responsive to dTMS treatment. Subsequent studies should systematically investigate potential common targets for dTMS treatment of depression, such as the primary motor cortex, ventromedial prefrontal cortex, or the anterior cingulate cortex, all of which have been associated with pain processing or pain relief following dTMS.…”

Section: The Remarkable Therapeutic Efficacy Of Dtms In Treating Depr...mentioning

confidence: 99%

Biomarker development perspective: Exploring comorbid chronic pain in depression through deep transcranial magnetic stimulation

Ju,

Zhao,

et al. 2024

Journal of Translational Internal Medicine

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Section: The Remarkable Therapeutic Efficacy Of Dtms In Treating Depr...mentioning

confidence: 99%

Biomarker development perspective: Exploring comorbid chronic pain in depression through deep transcranial magnetic stimulation

Ju,

Zhao,

et al. 2024

Journal of Translational Internal Medicine

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“…In addition, a lack of dopamine in the substantia nigra can lead to an increase in synaptic plasticity, which can contribute to a decrease in the pain sensitivity threshold. Furthermore, reduced dopamine contributes to nonmotor impairments such as anxiety, depression, and insomnia [36][37][38], which are known to be associated with increased pain in PwP [13,14]. Therefore, as the pathways of pain are similar in people with and without PD, all pain experienced by PwP is likely to be influenced by the presence of PD.…”

Section: Pain In Parkinson's Diseasementioning

confidence: 99%

Pain and the Non-Pharmacological Management of Pain in People with Parkinson’s Disease

Allen,

Romaliiska,

Naisby

2024

JPD

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Pain is a distressing and universal experience, yet everyone’s pain experience is influenced by a complex array of biological, psychological, and social factors. For people with Parkinson’s disease (PwP), these biopsychosocial factors include neurodegeneration and the psychological and social factors that accompany living with a chronic, neurodegenerative condition in addition to the factors experienced by those in the general population (e.g., living with co-morbidities such as osteoarthritis). The way these factors influence each individual is likely to determine which pain management strategies are optimal for them. This review first describes pain and the biopsychosocial model of pain. It explores how pain is classified in Parkinson’s disease (PD) and describes the three main types of pain: nociceptive, neuropathic, and nociplastic pain. This background provides context for a discussion of non-pharmacological pain management strategies that may aid in the management of pain in PwP; exercise, psychological strategies, acupuncture and massage. While there is little PD-specific research to inform the non-pharmacological management of pain, findings from current PD research are combined with that from chronic pain research to present recommendations for clinical practice. Recommendations include assessment that incorporates potential biopsychosocial contributors to pain that will then guide a holistic, multi-modal approach to management. As exercise provides overall benefits for PwP, those with chronic pain should be carefully monitored with exercise prescribed and adjusted accordingly. Research is needed to develop and evaluate multi-modal approaches to pain management that are delivered in a biopsychosocial framework.

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“…It is featured by motor symptoms like bradykinesia, resting tremor, rigidity, as well as postural instability. However, PD is a complicated disorder, accompanied with numerous non-motor symptoms (NMSs), including constipation, cognitive impairment, chronic pain, anxiety, as well as rapid eye movement (REM) sleep behavior disorder (RBD) (Kalia and Lang, 2015;Zhou et al, 2022). RBD is distinguished by anomalous actions and the absence of muscle atonia in the REM sleep, thereby classifying it as a parasomnia.…”

Section: Introductionmentioning

confidence: 99%

MRI brain structural and functional networks changes in Parkinson disease with REM sleep behavior disorders

Wang,

Zhu,

Zhou

et al. 2024

Front. Aging Neurosci.

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BackgroundRapid eye movement sleep behavior disorder (RBD) is common in individuals with Parkinson’s disease (PD). In spite of that, the precise mechanism underlying the pathophysiology of RBD among PD remains unclear.ObjectiveThe aim of the present study was to analyze gray matter volumes (GMVs) as well as the changes of functional connectivity (FC) among PD patients with RBD (PD-RBD) by employing a combination of voxel-based morphometry (VBM) and FC methods.MethodsA total of 65 PD patients and 21 healthy control (HC) subjects were included in this study. VBM analyses were performed on all subjects. Subsequently, regions with significant different GMVs between PD patients with and without RBD (PD-nRBD) were selected for further analysis of FC. Correlations between altered GMVs and FC values with RBD scores were also investigated. Additionally, receiver operating characteristic (ROC) curves were employed for the evaluation of the predictive value of GMVs and FC in identifying RBD in PD.ResultsPD-RBD patients exhibited lower GMVs in the left middle temporal gyrus (MTG) and bilateral cuneus. Furthermore, we observed higher FC between the left MTG and the right postcentral gyrus (PoCG), as well as lower FC between the bilateral cuneus (CUN) and the right middle frontal gyrus (MFG) among PD-RBD patients in contrast with PD-nRBD patients. Moreover, the GMVs of MTG (extending to the right PoCG) was positively correlated with RBD severity [as measured by REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) score]. Conversely, the FC value between the bilateral CUN and the right MTG in PD-RBD patients was negatively correlated with RBDSQ score.ConclusionThis study revealed the presence replace with GMV and FC changes among PD-RBD patients, which were closely linked to the severity of RBD symptoms. Furthermore, the combination of basic clinical characteristics, GMVs and FC values effectively predicted RBD for individuals with PD.

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Cortical synaptic mechanism for chronic pain and anxiety in Parkinson’s disease

Cited by 5 publications

References 34 publications

Biomarker development perspective: Exploring comorbid chronic pain in depression through deep transcranial magnetic stimulation

Biomarker development perspective: Exploring comorbid chronic pain in depression through deep transcranial magnetic stimulation

Pain and the Non-Pharmacological Management of Pain in People with Parkinson’s Disease

MRI brain structural and functional networks changes in Parkinson disease with REM sleep behavior disorders

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