Cortical Surface Thickness in the Middle-Aged Brain with White Matter Hyperintense Lesions

Zhuang, Yi; Zeng, Xianjun; Wang, Bo; Huang, Muhua; Gong, Honghan; Zhou, Fuqing

doi:10.3389/fnagi.2017.00225

Cited by 18 publications

(28 citation statements)

References 35 publications

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“…Ying Zhang et al (our preliminary study) 15 Used MRI technology in a study on cortical thickness of white matter hyper signal lesions in middle-aged and elderly people, in this study, we follow the methods of Zhang:…”

Section: Methodsmentioning

confidence: 99%

“…The following imaging parameters were used in the study: (1) three-dimensional high-resolution T1WI: repetition time/echo time = 1900/2.26 ms, field of view = 215 × 230 mm, matrix = 240 × 256, and 176 sagittal slices with a 1.0-mm thickness; (2) turbo spin echo-imaging sequence for T2WI scans: repetition time/echo time = 5100/117 ms, field of view = 240 × 240 mm, matrix = 416 × 416, number of excitations = 3, echo train length = 11, 22 axial slices with a 6.5-mm thickness; and (3) FLAIR imaging: repetition time/echo time/inversion time = 7000/79/2500 ms, 50 slices, 240 × 217 matrix, 0.43 × 0.43 × 2 mm 3 voxels. The MRI data were visually inspected for obvious artifacts arising from subject motion and instrument malfunction 15 .…”

Section: Methodsmentioning

confidence: 99%

“…This processing runs MATLAB 8.4 (R2014b; MathWorks, Natick, MA, USA). In short, T1WI data is the tissue of bias-field correction, skull dissection, alignment with the Montreal Neurological Institute standard space (MNI-152 template), segmentation into GM, WM, or cerebrospinal fluid within the same reproductive model 15 , 16 . In order to improve registration accuracy, a group-specific template was established using the Lie Algebra Diffeomorphic Anatomical Registration Through Exponentiated (DARTEL) algorithm in statistical parameter mapping (version12), and the non-linear transformation of individuals to the template was calculated 15 .…”

Section: Methodsmentioning

confidence: 99%

“…CAT12 is a new fully automatic method that measures cortical thickness and reconstructs the central surface in one step 9 , 15 . The program uses tissue segmentation to estimate the WM distance and uses the neighbor relationship described by the WM distance to project a local maximum (equal to the thickness of the cortex) to other GM voxels.…”

Section: Methodsmentioning

confidence: 99%

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Evidence of cortical thickness reduction and disconnection in high myopia

Huang

et al. 2020

Sci Rep

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High myopia (HM) is associated with impaired long-distance vision. accumulating evidences reported that abnormal visual experience leads to dysfunction in brain activity in HM even corrected. However, whether the long-term of abnormal visual experience lead to neuroanatomical changes remain unknown, the aim at this study is to investigate the alternation of cortical surface thickness in HM patients. 82 patients with HM (HM groups), 57 healthy controls (HC groups) were recruited. All participants underwent high-resolution T1 and resting-state functional magnetic resonance imaging (MRI) scans. The cortical thickness analysis was preformed to investigate the neuroanatomical changes in HM patients using computational anatomy toolbox (CAT 12) toolbox. Compare with HCs, HM patients showed decreased the cortical surface thickness in the left middle occipital gyrus (MOG), left inferior parietal lobule (IPL), right inferior temporal gyrus (ITG), right precuneus, right primary visual area 1 (V1), right superior temporal gyrus (STG), right superior parietal lobule (SPL), right occipital pole, and right the primary motor cortex (M1), and increased to the parietal operculum (OP4) (P < 0.01, FWE-corrected), the mean cortical thickness of right orbitofrontal cortex (OFC), right dorsolateral prefrontal cortex (DLPFC) and right subcallosal cortex showed negatively correlation between clinical variables (axis length (ALM), the average macular thickness (AMT), keratometer (KER) 1, KER2, the mean KER, the mean macular fovea thickness (MFK), the refractive diopter) in HM patients. Our result mainly provided an evidence of cortical thickness reduction and disconnection in visual center and visual processing area, and cortical thickness increase in left multimodal integration region in HM patients. This may provide important significance of the study of the neural mechanism of HM.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Evidence of cortical thickness reduction and disconnection in high myopia

Huang

et al. 2020

Sci Rep

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show abstract

“…This approach allows handling partial volume information, sulcal blurring, and sulcal asymmetries without explicit sulcus reconstruction. For inter-subject comparisons, cortical thickness maps were resampled into a common coordinate system and smoothed using a 15 mm Gaussian heat kernel ( Yotter et al, 2011 ; Zhuang et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Brain structural evidence for a frontal pole specialization in glossolalia

et al. 2020

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Glossolalia is defined as the ritual oral production of phoneme sequences without recognizable semantic content. The functional underpinnings of glossolalia, and notably whether it consists of a highly specific or ordinary behavior, remain largely unresolved. We addressed this question by measuring the structural brain remodeling associated with the extensive practice of glossolalia in thirty experts. This approach enabled us to circumvent the limitations of functional imaging to reveal the neural correlates of behaviors elicited in specific contexts and involving movements incompatible with most imaging methods. Whole-brain regression analyses of glossolalia expertise with indices of grey and white matter structure revealed positive associations between practice time and grey matter volume within the left frontal pole and the right middle frontal gyrus. These findings suggest that glossolalia involves a degree of neurocognitive specialization, though not at the level of language control and production networks, but within domain-general executive areas. They further call for including multi-tasking and interference suppression as key processes in models of unrecognizable speech production. Our results also concur with current demonstrations that measures of brain structural remodeling may help identifying whether cognitive skills depend on networks specialization or on a recycling of already existing processes.

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Empirical support for the vascular apathy hypothesis: A structured review

Wouts

Kessel

Beekman

et al. 2019

Int J Geriat Psychiatry

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ObjectivesA systematic review of the relationship between subclinical small vessel disease (SSVD) in the general population and apathy to examine the hypothesis that apathy has a vascular basis.MethodsWe searched for studies on associations between apathy and SSVD, operationalized as white matter hyperintensities (WMH) or white matter diffusivity changes, lacunar infarcts, cerebral microbleeds, decreasing cortical thickness, and perivascular spaces, while also peripheral proxies for SSVD were considered, operationalized as ankle brachial pressure index (ABI), intima media thickness, arterial stiffness, cardio‐femoral pulse wave velocity, hypertension, or cardiovascular disease. Only eligible retrospective and prospective observational studies conducted in the general population were included.ResultsThe 14 studies eligible for review examined the associations between apathy and hypertension (3), ABI (1), arterial stiffness (1), cardiovascular disease (2), WMH (3), white matter diffusivity (2), cerebral microbleeds (1), or cortical thickness (3). Arterial stiffness and white matter diffusivity were not related to apathy, while the associations with cortical thickness were contradictory. Cross‐sectional studies in the general population did find evidence of apathy being associated with WMH, CM, cardiovascular disease, hypertension, and ABI, and cardiovascular disease was prospectively associated with apathy. The methodologies of the studies reviewed were too heterogeneous to perform meta‐analyses.ConclusionsAlthough more prospective evidence is needed and vascular depression needs to be controlled for, cardiovascular disease, hypertension, and ABI as proxies for SSVD, and WMH and cerebral microbleeds as direct measures of SSVD have been found to be associated with apathy in the general population, supporting the hypothesis of vascular apathy.

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Cortical Surface Thickness in the Middle-Aged Brain with White Matter Hyperintense Lesions

Cited by 18 publications

References 35 publications

Evidence of cortical thickness reduction and disconnection in high myopia

Evidence of cortical thickness reduction and disconnection in high myopia

Brain structural evidence for a frontal pole specialization in glossolalia

Empirical support for the vascular apathy hypothesis: A structured review

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