Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF

Ninomiya, Midori; Numakawa, Tadahiro; Adachi, Naoki; Furuta, Miyako; Chiba, Shuichi; Richards, Misty; Shibata, Shigenobu

doi:10.1016/j.neulet.2010.03.082

Cited by 22 publications

(15 citation statements)

References 34 publications

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“…In line with our data, unchanged levels of BDNF were measured in sera of intrauterine growth retarded neonates, as well as in cortical neurons derived from intrauterine growth retarded rats (Malamitsi‐Puchner et al, 2007). However, in contrast to our findings, TrkB expression has previously been shown to be downregulated (Malamitsi‐Puchner et al, 2007; Ninomiya et al, 2010).…”

Section: Discussioncontrasting

confidence: 99%

Long‐term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

Prickaerts

Gieling

Bruder

et al. 2013

Intl J of Devlp Neuroscience

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In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates.

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Section: Discussioncontrasting

confidence: 99%

Long‐term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

Prickaerts

Gieling

Bruder

et al. 2013

Intl J of Devlp Neuroscience

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“…Polymorphisms in the GRIN2A gene are associated with epilepsy and different neurological and mental disorders [100–104]. A decreased gene expression of GRIN2A in rats after intrauterine growth retardation suggests a possible role for this gene in fetal growth and development [105]. LRP8 encodes for a member of the LDL receptor family.…”

Section: Discussionmentioning

confidence: 99%

Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study

et al. 2017

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BackgroundPrenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leading to an adverse cardio-metabolic risk profile at school age. However, the molecular mechanisms involved have not yet been resolved. It was hypothesized that epigenetics might be involved. The aim of the present study was therefore to investigate whether DNA methylation patterns in blood cells were related to prenatal pesticide exposure level, PON1 Q192R genotype, and associated metabolic effects observed in the children.MethodsWhole blood DNA methylation patterns in 48 children (6–11 years of age), whose mothers were occupationally unexposed or exposed to pesticides early in pregnancy, were determined by Illumina 450 K methylation arrays.ResultsA specific methylation profile was observed in prenatally pesticide exposed children carrying the PON1 192R-allele. Differentially methylated genes were enriched in several neuroendocrine signaling pathways including dopamine-DARPP32 feedback (appetite, reward pathways), corticotrophin releasing hormone signaling, nNOS, neuregulin signaling, mTOR signaling, and type II diabetes mellitus signaling. Furthermore, we were able to identify possible candidate genes which mediated the associations between pesticide exposure and increased leptin level, body fat percentage, and difference in BMI Z score between birth and school age.ConclusionsDNA methylation may be an underlying mechanism explaining an adverse cardio-metabolic health profile in children carrying the PON1 192R-allele and prenatally exposed to pesticides.Electronic supplementary materialThe online version of this article (doi:10.1186/s13148-017-0336-4) contains supplementary material, which is available to authorized users.

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“…Only one study found that behavioral training improved learning and memory performance in IUGR male rats (Xuelan et al, 2008). Brain disturbances, including delayed neural migration , lower cortical plate density (Hayakawa et al, 1999;Saito et al, 2009), decreased BDNF mRNA levels , and suppressed cellular BDNF signaling (Ninomiya et al, 2010), have been reported in TXA2-induced IUGR rats. Accordingly, we did not expect to see improvements in working memory and in the anxiogenic response in rats subjected to SDS.…”

Section: A) Elevated Plus Maze B) T-mazementioning

confidence: 99%

“…IUGR individuals may be vulnerable to negative social interactions, given that rats with IUGR that is induced by systemic exposure to thromboxane A2 (TXA2) during pregnancy exhibit brain disturbances that can include delayed neural migration , reduced cortical plate density (Hayakawa et al, 1999;Saito et al, 2009), reduced levels of brain-derived neurotrophic factor (BDNF) mRNA , and suppressed BDNF cellular signaling (Ninomiya et al, 2010). However, the adaptability of IUGR rats to stress is more complex than it seemed at first.…”

Section: Introductionmentioning

confidence: 99%

Exposure to social defeat stress in adolescence improves the working memory and anxiety-like behavior of adult female rats with intrauterine growth restriction, independently of hippocampal neurogenesis

Furuta

Ninomiya-Baba

Chiba

et al. 2015

Hormones and Behavior

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Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF

Cited by 22 publications

References 34 publications

Long‐term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

Long‐term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study

Exposure to social defeat stress in adolescence improves the working memory and anxiety-like behavior of adult female rats with intrauterine growth restriction, independently of hippocampal neurogenesis

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