Exposure to social defeat stress in adolescence improves the working memory and anxiety-like behavior of adult female rats with intrauterine growth restriction, independently of hippocampal neurogenesis

Furuta, Miyako; Ninomiya-Baba, Midori; Chiba, Shuichi; Funabashi, Toshiya; Akema, Tatsuo

doi:10.1016/j.yhbeh.2015.01.010

Cited by 9 publications

(5 citation statements)

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“…We have previously shown that cell proliferation (Ki67+) in the subventricular zone is increased in IUGR fetal guinea pigs (Tolcos et al (2015), and others report that ischemia in adult rats increases neurogenesis (Jin et al, 2001; Jin et al, 2003), consistent with the findings in the current study. In a model of IUGR induced by systemic exposure to thromboxane A2, increased cell proliferation (Brd‐U labeled cells), but not differentiation (Brd‐U/NeuN colabeled cells) in rats during adulthood (Furuta et al, 2015) suggest that newly generated cells may not continue into subsequent phases of neurogenesis, however our results suggest the contrary, at least in adolescence. Alternatively, the observed increase in DCX+ linear density may have occurred as a result of an increased sensitivity to learning‐modulated neurogenesis, as previously reported for adult‐generated neurons in the DG (Gould, Beylin, Tanapat, Reeves, & Shors, 1999; Leuner et al, 2004).…”

Section: Discussioncontrasting

confidence: 52%

Hippocampal neurogenesis and memory in adolescence following intrauterine growth restriction

et al. 2020

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Intrauterine growth restriction (IUGR) is associated with hippocampal alterations that can increase the risk of short‐term memory impairments later in life. Despite the role of hippocampal neurogenesis in learning and memory, research into the long‐lasting impact of IUGR on these processes is limited. We aimed to determine the effects of IUGR on neuronal proliferation, differentiation and morphology, and on memory function at adolescent equivalent age. At embryonic day (E) 18 (term ∼E22), placental insufficiency was induced in pregnant Wistar rats via bilateral uterine vessel ligation to generate IUGR offspring (n = 10); control offspring (n = 11) were generated via sham surgery. From postnatal day (P) 36–44, spontaneous location recognition (SLR), novel object location and recognition (NOL, NOR), and open field tests were performed. Brains were collected at P45 to assess neurogenesis (immunohistochemistry), dendritic morphology (Golgi staining), and brain‐derived neurotrophic factor expression (BDNF; Western blot analysis). In IUGR versus control rats there was no difference in object preference in the NOL or NOR, the similar and dissimilar condition of the SLR task, or in locomotion and anxiety‐like behavior in the open field. There was a significant increase in the linear density of immature neurons (DCX+) in the subgranular zone (SGZ) of the dentate gyrus (DG), but no difference in the linear density of proliferating cells (Ki67+) in the SGZ, nor in areal density of mature neurons (NeuN+) or microglia (Iba‐1+) in the DG in IUGR rats compared to controls. Dendritic morphology of dentate granule cells did not differ between groups. Protein expression of the BDNF precursor (pro‐BDNF), but not mature BDNF, was increased in the hippocampus of IUGR compared with control rats. These findings highlight that while the long‐lasting prenatal hypoxic environment may impact brain development, it may not impact hippocampal‐dependent learning and memory in adolescence.

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Section: Discussioncontrasting

confidence: 52%

Hippocampal neurogenesis and memory in adolescence following intrauterine growth restriction

et al. 2020

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“…= [214] ↓4-23% [79,87,88,[93][94][95][96] = [201,215] ↓7-52% [91,92,[97][98][99][100][101]216] ↓9.5-14% [83,89] = [84] ↓[128, 129,131,146] ↓8-40% [99,112,114,115,160,203,217,218] ↓36-42% [145,162] ↓18-44% [102, 116-118, 163, 212] ↓42-48% [122,124,125] ↓17-28% [132,[134][135][136][137][138][139][140][141] Brain size = [214] ↓cerebrum, 11% [79] ↓11-66% [90,…”

Section: Birth Weightmentioning

confidence: 99%

“…Corpus callosum ↓ [115] ↓width [162] NEURONAL DENSITY Cerebrum = [79] ↓insular, temporal and occipital cortex, indirect evidence [117] Hippocampus = [85] ↑ neuronal proliferation, adolescent females [131] = [113,115] ↑degenerating neurons, CA3 [113] ↓indirect evidence [117] Dentate gyrus = [101] Cerebellum = [79] ↓ indirect evidence via MRI [117] Fornix ↑ degenerating neurons [113] Entorhinal cortex ↓ [113,115] ↑ degenerating neurons [113] Cingulate cortex = [113] External capsule ↑ degenerating neurons [113] Prefrontal cortex = [115] ↓ indirect evidence [117] GABAergic interneurons ↑ prefrontal cortex [115] …”

Section: ↓[162]mentioning

confidence: 99%

“…Behavioural anxiety = male pups [79] =/↑ adult males [93,94] ↓ adults [98,216] ↑ reactivity to physical restraint and surprise, adults [84] ↑ adolescent females = adolescent males [131] ↑ adults [117] ↑ low birth weight female lambs [150] Spontaneous ambulation = adult males [94,95] ↑ females [165] ↑ in isolation tasks, adults [84] ↑ adults [113][114][115] ↓ adult males [160] ↓ Hyperactivity ↑ adult females [165] ↑adults [113][114][115] Exploratory behaviour ↑adult females [216] ↑adults [113][114][115] ↓ adults [117,163] Response to novelty ↓novelty seeking, adults [84] = adults [113] …”

Section: Behaviourmentioning

confidence: 99%

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Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

Hunter

Hazel

Kind

et al. 2016

Physiology & Behavior

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After the embargo period via non-commercial hosting platforms such as their institutional repository  via commercial sites with which Elsevier has an agreement In all cases accepted manuscripts should: link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article

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“…Finally, working memory performances in social defeated animals varied, in delay- and species-dependent manners. In the T-maze alternation task, mice displayed a decrease in alternation rate as soon as the 5-seconds delay [ 146 ] whereas the alternation rate was not affected in rats, neither at 10 or 30 or 60 s delays [ 147 , 148 ]. The delay must rise to 90 s to induce a deficit in working memory in adult defeated-rats compared to controls [ 147 ].…”

Section: Working Memory Deficits In Rodent Models Of Anxiety/deprementioning

confidence: 99%

Cognitive Dysfunction in Major Depressive Disorder. A Translational Review in Animal Models of the Disease

et al. 2016

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Major Depressive Disorder (MDD) is the most common psychiatric disease, affecting millions of people worldwide. In addition to the well-defined depressive symptoms, patients suffering from MDD consistently complain about cognitive disturbances, significantly exacerbating the burden of this illness. Among cognitive symptoms, impairments in attention, working memory, learning and memory or executive functions are often reported. However, available data about the heterogeneity of MDD patients and magnitude of cognitive symptoms through the different phases of MDD remain difficult to summarize. Thus, the first part of this review briefly overviewed clinical studies, focusing on the cognitive dysfunctions depending on the MDD type. As animal models are essential translational tools for underpinning the mechanisms of cognitive deficits in MDD, the second part of this review synthetized preclinical studies observing cognitive deficits in different rodent models of anxiety/depression. For each cognitive domain, we determined whether deficits could be shared across models. Particularly, we established whether specific stress-related procedures or unspecific criteria (such as species, sex or age) could segregate common cognitive alteration across models. Finally, the role of adult hippocampal neurogenesis in rodents in cognitive dysfunctions during MDD state was also discussed.

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Exposure to social defeat stress in adolescence improves the working memory and anxiety-like behavior of adult female rats with intrauterine growth restriction, independently of hippocampal neurogenesis

Cited by 9 publications

References 61 publications

Hippocampal neurogenesis and memory in adolescence following intrauterine growth restriction

Hippocampal neurogenesis and memory in adolescence following intrauterine growth restriction

Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

Cognitive Dysfunction in Major Depressive Disorder. A Translational Review in Animal Models of the Disease

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