Cortical Modulation of theCardiovascular System

Verberne, Anthony J.M.; Owens, Neil Craig

doi:10.1016/s0301-0082(97)00056-7

Cited by 319 publications

(226 citation statements)

References 220 publications

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“…Also noteworthy is that longstanding animal evidence has established that the pACC and medial prefrontal cortex are involved in autonomic-cardiovascular regulation (Verbene and Owens, 1998). Accordingly, we executed ROI analyses testing whether MAP reactivity varied with pACC activation across individuals.…”

Section: Map Reactivity and Perigenual Cingulate Activationmentioning

confidence: 99%

“…Notably, neither area showed volumetric changes or differential amygdala-connectivity in association with MAP reactivity. Although densely networked with the amygdala, the insula can regulate cardiovascular function through autonomic mechanisms that do not entail an obligatory amygdala pathway (Yasui et al, 1991;Cechetto, 1994;Verbene and Owens, 1998). Furthermore, the posterior cingulate is a functionally heterogeneous area that is indirectly networked with the amygdala and not extensively networked with autonomiccardiovascular control areas (Mayberg, 1997;Vogt et al, 2006;Stein et al, 2007).…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

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Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala

Gianaros¹,

Sheu²,

Matthews³

et al. 2008

J. Neurosci.

244

222

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Individuals who exhibit exaggerated blood pressure reactions to psychological stressors are at risk for hypertension, ventricular hypertrophy, and premature atherosclerosis; however, the neural systems mediating exaggerated blood pressure reactivity and associated cardiovascular risk in humans remain poorly defined. Animal models indicate that the amygdala orchestrates stressor-evoked blood pressure reactions via reciprocal signaling with corticolimbic and brainstem cardiovascular-regulatory circuits. Based on these models, we used a multimodal neuroimaging approach to determine whether human individual differences in stressor-evoked blood pressure reactivity vary with amygdala activation, gray matter volume, and functional connectivity with corticolimbic and brainstem areas implicated in stressor processing and cardiovascular regulation. We monitored mean arterial pressure (MAP) and concurrent functional magnetic resonance imaging BOLD signal changes in healthy young individuals while they completed a Stroop color-word stressor task, validated previously in epidemiological studies of cardiovascular risk. Individuals exhibiting greater stressor-evoked MAP reactivity showed (1) greater amygdala activation, (2) lower amygdala gray matter volume, and (3) stronger positive functional connectivity between the amygdala and perigenual anterior cingulate cortex and brainstem pons. Individual differences in amygdala activation, gray matter volume, and functional connectivity with corticolimbic and brainstem circuits may partly underpin cardiovascular disease risk by impacting stressor-evoked blood pressure reactivity.

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Section: Map Reactivity and Perigenual Cingulate Activationmentioning

confidence: 99%

Section: Limitations and Future Directionsmentioning

confidence: 99%

Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala

Gianaros¹,

Sheu²,

Matthews³

et al. 2008

J. Neurosci.

244

222

View full text Add to dashboard Cite

show abstract

“…12 However, medullary neurons localised within the rostral ventrolateral medullar (RVLM) are thought to be responsible for the maintenance of peripheral vascular tone and arterial blood pressure. 2,13 RVLM neurons normally provide tonic innervation to the SPN located within the lateral horns of the spinal grey matter of the thoracic and upper lumbar spinal segments.…”

Section: Physiology and Neuroanatomy Of Cardiovascular Controlmentioning

confidence: 99%

Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology

2005

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Motor and sensory deficits are well-known consequences of spinal cord injury (SCI). During the last decade, a significant number of experimental and clinical studies have focused on the investigation of autonomic dysfunction and cardiovascular control following SCI. Numerous clinical reports have suggested that unstable blood pressure control in individuals with SCI could be responsible for their increased cardiovascular mortality. The aim of this review is to outline the incidence and pathophysiological mechanisms underlying the orthostatic hypotension that commonly occurs following SCI. We describe the clinical abnormalities of blood pressure control following SCI, with particular emphasis upon orthostatic hypotension. Possible mechanisms underlying orthostatic hypotension in SCI, such as changes in sympathetic activity, altered baroreflex function, the lack of skeletal muscle pumping activity, cardiovascular deconditioning and altered salt and water balance will be discussed. Possible alterations in cerebral autoregulation following SCI, and the impact of these changes upon cerebral perfusion are also examined. Finally, the management of orthostatic hypotension will be considered.

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“…Kuniecki et al, 2003;Pfurtscheller et al, 2007). In addition to local regulatory mechanisms of the heart and blood vessels the cardiovascular control involves inputs of the central nervous system on the effector components of the cardiovascular system (Verberne and Owens, 1998). In particular, the genesis of short-term, beat to beat variations in heart rate has been described to be influenced by autonomic and central nervous regulations (Task Force, 1996).…”

Section: Introductionmentioning

confidence: 99%

I got it! Transient cardiovascular response to the perception of humor

Lackner

Weiss

Schulter

et al. 2013

Biological Psychology

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a b s t r a c tThe aim of the present study was to examine the transient cardiovascular response to the perception of humor, that is, the impact of the cognitive process of insight as well as the modulation of the response by the affective appraisal of the humor. To this end transient heart rate, stroke volume, cardiac output, and blood pressure responses were obtained in the immediate context of detecting the punch line in cartoons. Fine-grained analysis of the transient behavior of cardiovascular variables during viewing the cartoons was contrasted to non-humorous cartoon-like pictures. The detection of a punch line was accompanied by relative heart rate acceleration in conjunction with increased cardiac output, which was more pronounced the more amusing the cartoons were perceived. These results provide first evidence of the usefulness of cardiovascular variables for detecting the moment of insight and the quantification of the size of the emotional response accompanying it.

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Cortical Modulation of theCardiovascular System

Cited by 319 publications

References 220 publications

Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala

Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala

Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology

I got it! Transient cardiovascular response to the perception of humor

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