Cortical inhibition within motor and frontal regions in alcohol dependence post-detoxification: A pilot TMS-EEG study

Naim-Feil, Jodie; Bradshaw, John L.; Rogasch, Nigel C.; Daskalakis, Zafiris J.; Sheppard, Dianne Melinda; Lubman, Dan I.; Fitzgerald, Paul B.

doi:10.3109/15622975.2015.1066512

Cited by 27 publications

(36 citation statements)

References 49 publications

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“…In healthy controls, acute ethanol exposure leads to an increase in the duration of the cortical silent period (Ziemann et al, 1995;Conte et al, 2008). Despite this acute change, CSP is not altered in individuals who have consumed alcohol chronically (Conte et al, 2008;Nardone et al, 2010b;Naim-Feil et al, 2016), even during withdrawal states (Nardone et al, 2010b). Similarly, inhibition can be enhanced and facilitation reduced by acute alcohol consumption in healthy controls (Ziemann et al, 1995), but no difference in magnitude could be found among detoxified individuals with a history of chronic alcohol use (Nardone et al, 2010a,b;Naim-Feil et al, 2016), despite facilitation being increased in withdrawal states (Nardone et al, 2010b).…”

Section: Using Transcranial Magnetic Stimulation Tomentioning

confidence: 99%

Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development

2018

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Although the last 50 years of clinical and preclinical research have demonstrated that addiction is a brain disease, we still have no neural circuit-based treatments for substance dependence or cue reactivity at large. Now, for the first time, it appears that a noninvasive brain stimulation technique known as transcranial magnetic stimulation (TMS), which is Food and Drug Administration approved to treat depression, may be the first tool available to fill this critical void in addiction treatment development. The goals of this review are to 1) introduce TMS as a tool to induce causal change in behavior, cortical excitability, and frontal-striatal activity; 2) describe repetitive TMS (rTMS) as an interventional tool; 3) provide an overview of the studies that have evaluated rTMS as a therapeutic tool for alcohol and drug use disorders; and 4) outline a conceptual framework for target selection when designing future rTMS clinical trials in substance use disorders. The manuscript concludes with some suggestions for methodological innovation, specifically with regard to combining rTMS with pharmacotherapy as well as cognitive behavioral training paradigms. We have attempted to create a comprehensive manuscript that provides the reader with a basic set of knowledge and an introduction to the primary experimental questions that will likely drive the field of TMS treatment development forward for the next several years.

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Section: Using Transcranial Magnetic Stimulation Tomentioning

confidence: 99%

Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development

2018

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“…Naim‐Feil et al () also found disrupted cortical excitability and reduced cortical inhibition in their prefrontal cortex stimulation TMS–EEG study. Our results are in line with these findings, although the aforementioned measurements were conducted on adults with an over 10‐year history of alcohol dependence during the post‐detoxification and a different study paradigm was used.…”

Section: Discussionmentioning

confidence: 91%

“…So far, however, only one TMS–EEG study has examined the effects of long‐term alcohol use. Reduced cortical inhibition after prefrontal cortex stimulation in the post‐detoxification of alcohol‐dependent patients was reported, suggesting that cortical hyper‐excitability is associated with chronic alcohol use (Naim‐Feil et al ).…”

Section: Introductionmentioning

confidence: 99%

Heavy alcohol use in adolescence is associated with altered cortical activity: a combined TMS–EEG study

et al. 2016

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Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and functional connectivity. In the central nervous system, the effects of alcohol are particularly mediated by alterations in gamma-aminobutyric acid (GABA)ergic neurotransmission, and TMS-evoked potentials (TEPs) N45 and N100 in EEG are known to reflect GABAergic function. However, no previous studies have examined the effects of long-term alcohol use in adolescence on TEPs. In this study, a total of 27 young adults with heavy alcohol use in adolescence and 25 age-matched, gender-matched and education-matched controls with little or no alcohol use participated in TMS-EEG measurements. The motor cortex (M1) was stimulated with an intensity of 90 percent of the resting motor threshold of the abductor pollicis brevis muscle. No significant differences were found in the resting motor threshold, TEP latencies or neuropsychological functioning between the groups. We observed an increase in the global mean field power in the time window of 54- to 75-millisecond post-TMS, as well as significant topographical differences in the P60 and N100 in those with a history of heavy drinking. Furthermore, there was a marked increase in the GABAergic N45 amplitude in alcohol users. These findings suggest that long-term alcohol use in adolescence, even when not meeting the diagnostic criteria for a disorder, is associated with changes in connectivity and cortical excitability.

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“…It should be noted that although the scope of this review was focused on TMS‐EEG biomarkers for MDD, BPD, and SCZ, there are a number of promising studies that have brought insights into the clinical neurophysiology of other psychiatric disorders, including attention‐deficit hyperactive disorder and autism . Very recently, TMS‐EEG has also been used to investigate the neural and network changes underlying substance‐use disorders . Future work in this field should focus on replicating these findings across different patient groups and different stages of the disorders, to help establish the reliability of these TMS‐EEG biomarkers and utilize concurrent pharmacological methodology to gain further insight into the neurobiological targets of these TMS indexes.…”

Section: Resultsmentioning

confidence: 99%

“…72,73 Very recently, TMS-EEG has also been used to investigate the neural and network changes underlying substance-use disorders. 74 Future work in this field should focus on replicating these findings across different patient groups and different stages of the disorders, to help establish the reliability of these TMS-EEG biomarkers and utilize concurrent pharmacological methodology to gain further insight into the neurobiological targets of these TMS indexes.…”

Section: Resultsmentioning

confidence: 99%

The Current and Future Potential of Transcranial Magnetic Stimulation With Electroencephalography in Psychiatry

Hui

Tremblay

Daskalakis

2019

Clin Pharma and Therapeutics

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The search for biological targets in psychiatric disorders is essential to better understand illness mechanisms and also to monitor and predict response to currently available therapeutic interventions. To this end, the combination of transcranial magnetic stimulation with electroencephalography (TMS‐EEG) has emerged as a powerful clinical research tool. TMS‐EEG allows cortical properties, such as excitability, inhibition, oscillatory activity, and connectivity, to be directly probed within a specific region of the cortex. This review will summarize the state of the current literature on TMS‐EEG and its potential to uncover biological targets in psychiatric illnesses, with a focus on major depressive disorder, bipolar disorder, and schizophrenia. Collectively, the reviewed studies suggest that alterations in gamma‐aminobutyric acid‐mediated inhibition and gamma oscillations in the dorsolateral prefrontal cortex and neighboring frontal regions are potential shared biomarkers in psychiatry, highlighting the potential of TMS‐EEG to help identify translational biomarkers.

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Cortical inhibition within motor and frontal regions in alcohol dependence post-detoxification: A pilot TMS-EEG study

Cited by 27 publications

References 49 publications

Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development

Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development

Heavy alcohol use in adolescence is associated with altered cortical activity: a combined TMS–EEG study

The Current and Future Potential of Transcranial Magnetic Stimulation With Electroencephalography in Psychiatry

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