Cortical/hippocampal monoamines, HPA-axis changes and aversive behavior following stress and restress in an animal model of post-traumatic stress disorder

Harvey, Brian H.; Brand, Linda; Jeeva, Zakkiyya Igbal; Stein, Dan J.

doi:10.1016/j.physbeh.2006.01.033

Cited by 111 publications

(65 citation statements)

References 55 publications

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“…41 The above-mentioned relationship between primary symmetry symptomatology and comorbid PTSD may also have a connection with dopamine, especially since altered dopaminergic activity has been suggested to compromise the ability to develop effective coping strategies following aversive situations in an animal model. 42 Several limitations should be acknowledged. Other genetic variants, or interactions with others, may play a role.…”

Section: Discussionmentioning

confidence: 99%

Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates

Löchner

McGregor

Hemmings

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD. Methods: Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without. Results: OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p o 0.01), had longer illness duration (p o 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p o 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for ANKK1 rs1800497, with more OCD patients with symmetry symptoms being homozygous for the A2 (CC) genotype (w 2 = 7.296; p = 0.026). Conclusion: Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the ANKK1 rs1800497 A2 variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile.

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Section: Discussionmentioning

confidence: 99%

Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates

Löchner

McGregor

Hemmings

et al. 2015

Rev. Bras. Psiquiatr.

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“…DA, 5-HT and NA levels were quantified by high-performance liquid chromatography (HPLC) with electrochemical detection [39]. Samples were weighed and thawed followed by the addition of 1 ml homogenization buffer (0.5 m M sodium metabisulphite; 0.3 m M Na 2 -EDTA; 0.1 M perchloric acid, 60%).…”

Section: Methodsmentioning

confidence: 99%

Late-Life Effects of Chronic Methamphetamine Exposure during Puberty on Behaviour and Corticostriatal Mono-Amines in Social Isolation-Reared Rats

Strauss¹,

Brink²,

Möller³

et al. 2014

Dev Neurosci

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Chronic methamphetamine (MA) abuse results in an acute psychosis indistinguishable from paranoid schizophrenia. However, less is known of the interaction between MA use and environmental insults, and how this contributes to late-onset psychopathology. Using social isolation rearing (SIR), a neurodevelopmental animal model of schizophrenia, we investigated the association between changes in corticostriatal mono-amines and putative behaviours related to MA-induced psychosis in isolation and group-housed rats following chronic MA or saline exposure. Weaned male offspring of MA-naive female Wistar rats, either group- or isolation-housed from postnatal day (PND) +21, received saline (2 ml/kg s.c. b.i.d.) or an escalating dose of MA (0.2-6 mg/kg s.c. b.i.d.) for 16 days from PND +35 to +50. On PND +78, offspring were tested for deficits in social interactive behaviour (SIB) and prepulse inhibition (PPI) of startle, with frontal cortex and striatum harvested for the assessment of mono-amine concentrations. SIR significantly reduced rearing time, staying together, approaching and anogenital sniffing (outward-directed SIB), but increased self-grooming and locomotor activity (self-directed SIB), and also induced profound deficits in PPI. Pubertal MA exposure in group-housed animals also induced similar alterations in outward- and self-directed SIB and reduced PPI. Combined MA + SIR exposure evoked a similarly intense behavioural response as SIR or MA separately, with no exacerbation evident. Neither treatment separately nor together affected corticostriatal serotonin or noradrenaline levels, although frontal cortical dopamine (DA) levels were significantly increased in SIR and MA + group-housed animals. A trend towards further elevated frontal cortical DA was noted in the MA + SIR treatment group. Striatal DA was unaltered by all treatments. This study provides the first evidence that chronic pubertal MA exposure evokes postpubertal psychosis-like behaviours in rats of similar intensity to that induced by a neurodevelopmental animal model of schizophrenia (SIR). Moreover, the study is unique in that these behavioural changes occur together with associated changes in frontal cortical but not striatal DA, without affecting other mono-amines, and strongly implicates frontal cortical DA changes in the psychotogenic effects of early-life MA exposure or environmental insult. Although MA exposure in animals with a history of environmental insult (i.e. MA + SIR) has similar effects, combined exposure was not additive with regard to behavioural or neurochemical changes. We conclude that a ceiling effect or compensatory mechanisms prevent more pronounced neurobehavioural deficits occurring following MA + SIR treatment, at least under the current study conditions.

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“…Using sequential restraint stress, swim stress, and halothane exposure, NA, 5-HT, and DA concentrations were elevated in the hippocampus after 7 d but not after 1 h. 73 Wilson and colleagues 74 exposed rats to a predator (cat) plus daily cage cohort changes. Using HPLC, they observed increased levels of NA and DOPAC in the hippocampus and PFC in the stress group, whereas 5-HT was lower in the PFC.…”

Section: Tbi and Monoamine Turnovermentioning

confidence: 99%

Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin

Kawa

Arborelius

Yoshitake

et al. 2015

Journal of Neurotrauma

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Exposure to improvised explosive devices can result in a unique form of traumatic brain injury-blast-induced traumatic brain injury (bTBI). At the mild end of the spectrum (mild bTBI [mbTBI]), there are cognitive and mood disturbances. Similar symptoms have been observed in post-traumatic stress disorder caused by exposure to extreme psychological stress without physical injury. A role of the monoaminergic system in mood regulation and stress is well established but its involvement in mbTBI is not well understood. To address this gap, we used a rodent model of mbTBI and detected a decrease in immobility behavior in the forced swim test at 1 d post-exposure, coupled with an increase in climbing behavior, but not after 14 d or later, possibly indicating a transient increase in anxiety-like behavior. Using in situ hybridization, we found elevated messenger ribonucleic acid levels of both tyrosine hydroxylase and tryptophan hydroxylase 2 in the locus coeruleus and the dorsal raphe nucleus, respectively, as early as 2 h post-exposure. High-performance liquid chromatography analysis 1 d post-exposure primarily showed elevated noradrenaline levels in several forebrain regions. Taken together, we report that exposure to mild blast results in transient changes in both anxiety-like behavior and brain region-specific molecular changes, implicating the monoaminergic system in the pathobiology of mbTBI.

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Cortical/hippocampal monoamines, HPA-axis changes and aversive behavior following stress and restress in an animal model of post-traumatic stress disorder

Cited by 111 publications

References 55 publications

Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates

Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates

Late-Life Effects of Chronic Methamphetamine Exposure during Puberty on Behaviour and Corticostriatal Mono-Amines in Social Isolation-Reared Rats

Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin

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