Cortical gyrification in children with attention deficit-hyperactivity disorder and prenatal alcohol exposure

Kilpatrick, Lisa A.; Joshi, Shantanu H.; O’Neill, Joseph; Kalender, Güldamla; Dillon, Andrea; Best, K; Narr, Katherine L.; Alger, Jeffry R.; Levitt, Jennifer G.; O’Connor, Mary J.

doi:10.1016/j.drugalcdep.2021.108817

Cited by 8 publications

(7 citation statements)

References 59 publications

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“…The current findings are also compatible with research linking inhibitory control to both ERI and right OFC (28,70,82,83). Furthermore, the association of lower LGI in right lateral OFC with higher ERI is consistent with previous work showing that lower LGI is associated with worse cognitive and behavioral functioning in other domains (84,85). In sum, our results dovetail with literatures on ERI, OFC function, and inhibitory control.…”

Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 92%

Neuroanatomical Correlates of Emotion-Related Impulsivity

Elliott

Esmail²,

Weiner³

et al. 2023

Biological Psychiatry

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Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 92%

Neuroanatomical Correlates of Emotion-Related Impulsivity

Elliott

Esmail²,

Weiner³

et al. 2023

Biological Psychiatry

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“…Executive function is often globally impaired with specific deficits in domains of set shifting/flexibility, concept formation/problem solving, planning, working memory, and inhibitory control, particularly on tasks involving complex information processing [ 50 , 58 ]. Notably, attention deficit/hyperactivity disorder (ADHD) is highly comorbid with FASD, and individuals with PAE and ADHD may demonstrate unique cognitive profiles and neurological abnormalities [ 59 ].…”

Section: Alcohol’s Effects On the Developing Brain And Cognitionmentioning

confidence: 99%

Prenatal and Postnatal Choline Supplementation in Fetal Alcohol Spectrum Disorder

Ernst

Gimbel²,

Water³

et al. 2022

Nutrients

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Fetal alcohol spectrum disorder (FASD) is common and represents a significant public health burden, yet very few interventions have been tested in FASD. Cognitive deficits are core features of FASD, ranging from broad intellectual impairment to selective problems in attention, executive functioning, memory, visual–perceptual/motor skills, social cognition, and academics. One potential intervention for the cognitive impairments associated with FASD is the essential nutrient choline, which is known to have numerous direct effects on brain and cognition in both typical and atypical development. We provide a summary of the literature supporting the use of choline as a neurodevelopmental intervention in those affected by prenatal alcohol. We first discuss how alcohol interferes with normal brain development. We then provide a comprehensive overview of the nutrient choline and discuss its role in typical brain development and its application in the optimization of brain development following early insult. Next, we review the preclinical literature that provides evidence of choline’s potential as an intervention following alcohol exposure. Then, we review a handful of existing human studies of choline supplementation in FASD. Lastly, we conclude with a review of practical considerations in choline supplementation, including dose, formulation, and feasibility in children.

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“…To increase insight in detailed brain development of alcohol exposed fetuses, it is important to perform repeated ultrasound examinations during pregnancy, preferably with advanced techniques such as three-dimensional neurosonography [ 56 , 57 ]. Additionally, different structures including the cerebellum, corpus callosum, thalami, and cortical folding processes should be examined [ 58 – 60 ].…”

Section: Discussionmentioning

confidence: 99%

Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study

Pielage,

El Marroun,

Odendaal

et al. 2023

BMC Med

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Background Prenatal alcohol exposure (PAE) is a worldwide public health concern. While PAE is known to be associated with low birth weight, little is known about timing and quantity of PAE on fetal growth. This study investigated the association between periconceptional and prenatal alcohol exposure and longitudinal fetal growth, focusing on timing and quantity in a high exposure cohort. Methods The Safe Passage Study was a prospective cohort study, including 1698 pregnant women. Two-dimensional transabdominal ultrasound examinations were performed to measure fetal femur length, abdominal and head circumference, and biparietal diameter, at three time points during pregnancy. Estimated fetal weight and Z-scores of all parameters were calculated. Trimester-specific alcohol exposure was assessed using the Timeline Followback method. To investigate the associations of specific timing of PAE and fetal growth, two models were built. One with alcohol exposure as accumulative parameter over the course of pregnancy and one trimester specific model, in which PAE was separately analyzed. Linear mixed models adjusted for potential confounders were applied with repeated assessments of both alcohol exposure and fetal growth outcomes. Results This study demonstrated that periconceptional and prenatal alcohol exposure were associated with reduced fetal growth. Effect sizes are displayed as estimated differences (ED) in Z-score and corresponding 95% confidence intervals (95% CIs). When investigated as accumulative parameter, PAE was related to a smaller femur length (ED30; − 0.13 (95% CI; − 0.22; − 0.04), ED36; − 0.14 (95% CI; − 0.25; − 0.04)) and a smaller abdominal circumference (ED36; − 0.09 (95% CI; − 0.18; − 0.01)). Periconceptional alcohol exposure was associated with a smaller abdominal circumference (ED30; − 0.14 (95% CI; − 0.25; − 0.02), ED36; − 0.22 (95% CI; − 0.37; − 0.06)) and a smaller estimated fetal weight (ED36; − 0.22 (95% CI; − 0.38; − 0.05)). Second trimester alcohol exposure was associated with a smaller abdominal circumference (ED30; − 0.49 (95% CI; − 0.86; − 0.12), ED36; − 0.70 (95% CI; − 1.22; − 0.17)) and estimated fetal weight (ED30; − 0.54 (95% CI; − 0.94; − 0.14), ED36; − 0.69 (95% CI; − 1.25; − 0.14)). No additional association of binge drinking was found besides the already observed association of PAE and fetal growth. Conclusions This study demonstrated that PAE negatively affects fetal growth, in particular when exposed during the periconception period or in second trimester. Our results indicate that potential negative consequences of PAE are detectable already before birth. Therefore, healthcare providers should actively address and discourage alcohol use during pregnancy.

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Cortical gyrification in children with attention deficit-hyperactivity disorder and prenatal alcohol exposure

Cited by 8 publications

References 59 publications

Neuroanatomical Correlates of Emotion-Related Impulsivity

Neuroanatomical Correlates of Emotion-Related Impulsivity

Prenatal and Postnatal Choline Supplementation in Fetal Alcohol Spectrum Disorder

Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study

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