Neuroanatomical Correlates of Emotion-Related Impulsivity

Elliott, Matthew V.; Esmail, Serajh A.S.; Weiner, Kevin S.; Johnson, Sheri L.

doi:10.1016/j.biopsych.2022.07.018

Cited by 9 publications

(10 citation statements)

References 100 publications

(127 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, while ERI has been well-explored and accepted as a transdiagnostic phenotype in clinical literature (61)(62)(63), explorations of OFC anatomy and psychopathology appears to be less explored, with few studies testing for similarities across diagnostic boundaries (64)(65)(66)(67)(68). To bridge between these parallel tracks, we recently proposed that ERI could serve as an intermediate psychological phenotype that emerges from the development of OFC and leads to psychopathology (10). Here, we extend this proposal to also include the emergence of neuroanatomical structures.…”

Section: Discussionmentioning

confidence: 99%

“…In previous work, Elliott and colleagues established a neuroanatomical link between OFC and ERI (10). Using a continuous global surface-based morphological measurement, the authors identified a link between ERI and the local gyrification of OFC.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers recruited participants through flyers, online advertising, and referrals from clinicians and excluded individuals with current alcohol or substance abuse disorders, a history of bipolar disorder or primary psychosis (as assessed by the SCID for DSM-5), or daily use of marijuana or sedating medications, as well as those with lifetime head trauma resulting in loss of consciousness for five or more minutes, low cognitive abilities (Orientation Memory Concentration Test (23) score of less than 7), MRI safety contraindications, neurological disorders, or inability to complete cognitive measures due to intellectual or language impairment. After researchers gave informed consent, participants completed diagnostic, behavioral, and neuroimaging sessions (10). Before the neuroimaging session, participants completed urine toxicology screening.…”

Section: Methodsmentioning

confidence: 99%

“…prior to any morphological analyses. The OFC sulci of interest in the present study were the: (1) olfactory sulcus (olfs), (2) transverse olfactory sulcus (tolfs), (3) transverse orbital sulcus (tos), (4) anterior section of the medial orbital sulcus (mos-a), (5) posterior section of the medial orbital sulcus (mos-p), (6) anterior section of the lateral orbital sulcus (los-a), (7) posterior section of the lateral orbital sulcus (los-p), (8) intermediate orbital sulcus (ios), (9) posterior orbital sulcus (pos), and (10) sulcus fragmentosus (sf). Figure 1a provides a visual representation of left and right hemispheres for reference.…”

Section: Methodsmentioning

confidence: 99%

“…Previous functional and structural imaging work has suggested a link between ERI, psychopathology more broadly, and the orbitofrontal cortex (OFC). For example, previous work identified (i) a qualitative link between the pattern of cortical indentations, or sulci, in OFC and clinical outcomes (reviewed in (9)) and (ii) a quantitative link between the local gyrification of OFC and ERI (10). Nevertheless, while a growing body of work has identified quantitative relationships between sulcal morphology in different parts of the cerebral cortex with multiple behavioral and psychiatric outcomes (11)(12)(13)(14)(15)(16)(17), it is presently unknown if there is an anatomo-cognitive link between the morphology of individual sulci in OFC and ERI.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Emotion-related impulsivity is related to orbitofrontal cortical sulcation

Hastings,

Willbrand,

Elliott

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

BackgroundEmotion-related impulsivity (ERI) describes the trait-like tendency toward poor self-control when experiencing strong emotions. ERI has been shown to be elevated across psychiatric disorders and predictive of the onset and worsening of psychiatric syndromes. Recent work has correlated ERI scores with the neuroanatomy of the orbitofrontal cortex (OFC). Informed by a growing body of research indicating that the morphology of cortical folds (sulci) can produce insights into behavioral outcomes, the present study modeled the association between ERI and the sulcal morphology of OFC at a finer scale than previously conducted.MethodsAnalyses were conducted in a transdiagnostic sample of 118 individuals with a broad range of psychiatric syndromes. We first manually defined over 2000 sulci across the 118 participants. We then implemented a model-based LASSO regression to relate OFC sulcal morphology to ERI and test whether effects were specific to ERI as compared to non-emotion-related impulsivity.ResultsThe LASSO regression revealed bilateral associations of ERI with the depth of eight OFC sulci. These effects were specific to ERI and were not observed in non-emotion-related impulsivity. In addition, we identified a new transverse component of the olfactory sulcus in every hemisphere that is dissociable from the longitudinal component based on anatomical features and correlation with behavior, which could serve as a new transdiagnostic biomarker.ConclusionsThe results of this data-driven investigation provide greater neuroanatomical and neurodevelopmental specificity on how OFC is related to ERI. As such, findings link neuroanatomical characteristics to a trait that is highly predictive of psychopathology.

show abstract