Cortical auditory evoked responses from an implanted ear after 50 years of profound unilateral deafness

McNeill, Celene; Sharma, Mridula; Purdy, Suzanne C.; Agung, Katrina

doi:10.1002/cii.343

Cited by 10 publications

(15 citation statements)

References 14 publications

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“…The cap was placed according to the International 10–20 system, with the contralateral earlobe as the reference (McNeill et al, 2007). Electro-ocular activity (EOG) was monitored so that eye movement artifacts could be identified and rejected during the offline analysis.…”

Section: Methodsmentioning

confidence: 99%

Mismatch negativity and adaptation measures of the late auditory evoked potential in cochlear implant users

et al. 2011

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A better understanding of the neural correlates of large variability in cochlear implant (CI) patients’ speech performance may allow us to find solutions to further improve CI benefits. The present study examined the mismatch negativity (MMN) and the adaptation of the late auditory evoked potential (LAEP) in 10 CI users. The speech syllable /da/ and 1-kHz tone burst were used to examine the LAEP adaptation. The amount of LAEP adaptation was calculated according to the averaged N1-P2 amplitude for the LAEPs evoked by the last 3 stimuli and the amplitude evoked by the first stimulus. For the MMN recordings, the standard stimulus (1-kHz tone) and the deviant stimulus (2-kHz tone) were presented in an oddball condition. Additionally, the deviants alone were presented in a control condition. The MMN was derived by subtracting the response to the deviants in the control condition from the oddball condition. Results showed that good CI performers displayed a more prominent LAEP adaptation than moderate-to-poor performers. Speech performance was significantly correlated to the amount of LAEP adaptation for the 1-kHz tone bursts. Good performers displayed large MMNs and moderate-to-poor performers had small or absent MMNs. The abnormal electrophysiological findings in moderate-to-poor performers suggest that long-term deafness may cause damage not only at the auditory cortical level, but also at the cognitive level.

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Section: Methodsmentioning

confidence: 99%

Mismatch negativity and adaptation measures of the late auditory evoked potential in cochlear implant users

et al. 2011

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“…Electrode placement was based on the International 10-20 system, using an Electro-Cap placed on the head of the participant, with the contralateral earlobe as the reference. This procedure has been found to reduce the stimulus artifact in some CI users (McNeill et al, 2007). Electro-ocular activity (EOG) was monitored so that eye movement artifacts could be identifi ed and rejected during the offl ine analysis.…”

Section: Electroencephalographic Recordingmentioning

confidence: 99%

The adaptive pattern of the late auditory evoked potential elicited by repeated stimuli in cochlear implant users

Zhang

Anderson

Samy

et al. 2010

International Journal of Audiology

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To describe the adaptive pattern of cortically generated auditory evoked potentials elicited by repeated stimuli via cochlear implants (CIs), the late auditory evoked potential (LAEP) was collected from nine postlingually deafened adult CI users. Tone bursts were presented in 30 trains consisting of 10 tone bursts each, with inter-stimulus intervals (ISIs) of 0.7 ms and inter-train intervals (ITIs) of 15s. The response to the first stimulus and the response to later tone bursts in the train were compared. Results showed that the LAEP for the first tone burst was larger than that for later tone bursts, displaying an adaptive pattern. This pattern appeared to be more prominent in CI users with good speech perception performance than in those with poorer performance. This finding is meaningful in the context of our future research to restore normal adaptation in CI users to improve their speech perception performance.

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“…1 The current study was undertaken to determine if changes in behavioral performance over time correspond to changes in electrophysiologic measures of auditory processing in a small group of postlingually deaf adults receiving a CI. The association between speech perception and auditory evoked potential measures (latencies, amplitudes) has been shown in cross-sectional group studies and longitudinal case studies of adult CI users, 4,[8][9][10][11][12][13][14][15][16][17] but there is limited published group data showing evoked potential and behavioral changes over time in adult CI users. 7,18 Middle latency response (MLR), obligatory cortical auditory evoked potentials (CAEPs), and mismatch negativity (MMN) auditory evoked potentials were measured and compared with speech perception scores recorded during the week the CI was activated and at 1, 3, 6, and 9 months postimplantation.…”

mentioning

confidence: 99%

Change in Speech Perception and Auditory Evoked Potentials over Time after Unilateral Cochlear Implantation in Postlingually Deaf Adults

Purdy

Kelly

2016

Semin Hear

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Speech perception varies widely across cochlear implant (CI) users and typically improves over time after implantation. There is also some evidence for improved auditory evoked potentials (shorter latencies, larger amplitudes) after implantation but few longitudinal studies have examined the relationship between behavioral and evoked potential measures after implantation in postlingually deaf adults. The relationship between speech perception and auditory evoked potentials was investigated in newly implanted cochlear implant users from the day of implant activation to 9 months postimplantation, on five occasions, in 10 adults age 27 to 57 years who had been bilaterally profoundly deaf for 1 to 30 years prior to receiving a unilateral CI24 cochlear implant. Changes over time in middle latency response (MLR), mismatch negativity, and obligatory cortical auditory evoked potentials and word and sentence speech perception scores were examined. Speech perception improved significantly over the 9-month period. MLRs varied and showed no consistent change over time. Three participants aged in their 50s had absent MLRs. The pattern of change in N1 amplitudes over the five visits varied across participants. P2 area increased significantly for 1,000- and 4,000-Hz tones but not for 250 Hz. The greatest change in P2 area occurred after 6 months of implant experience. Although there was a trend for mismatch negativity peak latency to reduce and width to increase after 3 months of implant experience, there was considerable variability and these changes were not significant. Only 60% of participants had a detectable mismatch initially; this increased to 100% at 9 months. The continued change in P2 area over the period evaluated, with a trend for greater change for right hemisphere recordings, is consistent with the pattern of incremental change in speech perception scores over time. MLR, N1, and mismatch negativity changes were inconsistent and hence P2 may be a more robust measure of auditory plasticity in adult implant recipients. P2 was still improving at 9 months postimplantation. Future studies should explore longitudinal changes over a longer period.

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Cortical auditory evoked responses from an implanted ear after 50 years of profound unilateral deafness

Cited by 10 publications

References 14 publications

Mismatch negativity and adaptation measures of the late auditory evoked potential in cochlear implant users

Mismatch negativity and adaptation measures of the late auditory evoked potential in cochlear implant users

The adaptive pattern of the late auditory evoked potential elicited by repeated stimuli in cochlear implant users

Change in Speech Perception and Auditory Evoked Potentials over Time after Unilateral Cochlear Implantation in Postlingually Deaf Adults

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