Cortical and trabecular bone distribution in the femoral neck in osteoporosis and osteoarthritis

Blain, Hubert; Chavassieux, Pascale; Portero-Muzy, Nathalie; Bonnel, F.; Canovas, François; Chammas, Michel; Maury, P.; Delmas, Pierre D.

doi:10.1016/j.bone.2008.07.236

Cited by 79 publications

(60 citation statements)

References 44 publications

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“…Because the distribution of compressive and tensile forces through the talus does not severely change with age, we speculate that the differently sized volumes of interest might be responsible for the greater bone loss in the body [34]. At first glance, the nearly unimpaired bone structure of the talar neck seemed contradictory given that the femoral neck has a similar weight-transmitting function and an age-related degradation of the femoral neck was reported [10,12]. Age-related cortical trabecularization and thinning were attributed to a higher risk of hip fracture in the elderly [9,10].…”

Section: Discussionmentioning

confidence: 95%

“…As a result of specimen destruction during histological preparation, there was no additional bone stock available for the analysis of other planes. However, the transition of trabeculae from the talar body to the head and neck or to the calcaneal facet transferring the load was demonstrated following tensile and compression forces [4,10]. Therefore, the evaluation of only one plane was needed to study age-and sex-related changes of the talar body, neck, and head simultaneously.…”

Section: Discussionmentioning

confidence: 99%

“…At first glance, the nearly unimpaired bone structure of the talar neck seemed contradictory given that the femoral neck has a similar weight-transmitting function and an age-related degradation of the femoral neck was reported [10,12]. Age-related cortical trabecularization and thinning were attributed to a higher risk of hip fracture in the elderly [9,10]. However, talar neck fractures have a low incidence at older age and are primarily seen in patients with a highimpact trauma [25,36].…”

Section: Discussionmentioning

confidence: 99%

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Bone Microarchitecture of the Talus Changes With Aging

Krause

Rupprecht

Mumme

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background Fractures of the talus in the elderly are rare and usually result from high-impact injuries, suggesting only minor age-related bone structure changes. However, total ankle replacement failures with age often result from talar subsidence, suggesting age-related bone loss in the talus. Despite a number of histological analyses of talar microarchitecture, the effects of age and sex on talar microarchitecture changes remain poorly defined.Questions/purposes The aim of this study was to analyze changes or differences in the trabecular microarchitecture of the talus with regard to (1) age and (2) sex. Methods Sixty human tali were harvested from 30 patients at autopsy of three different age groups (20-40, 41-60, 61-80 years). The specimens were analyzed by radiography, micro-CT, and histological analysis. Given that there was no difference between the left and right talus, static histomorphometric parameters were assessed in three regions of interest of the right talus only (body, neck, head; n = 30). Results The talar body, neck, and head were affected differently by age-related changes. The greatest loss of bone volume with age was seen in the talar body (estimate: À0.239; 95% confidence interval [CI], À0.365 to À0.114; p \ 0.001). In the talar neck (estimate: À0.165; 95% CI, À0.307 to À0.023; p = 0.025), bone loss was only moderate and primarily was the result of reduction in trabecular thickness (estimate: À1.288; 95% CI, À2.449 to À0.127; p = 0.031) instead of number (estimate: À0.001; 95% CI, À0.005 to À0.003; p = 0.593). Bone structure changes were independent of sex. Conclusions Age-related bone structure changes predominantly occur in the talar body, which poses a potential risk factor for total ankle replacement loosening. The moderate changes in the talar neck might explain the persistent low incidence of talar neck fractures with age.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bone Microarchitecture of the Talus Changes With Aging

Krause

Rupprecht

Mumme

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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“…The risk of hip fracture increases in subjects with impaired bone microarchitecture (cortical thinning, deterioration of trabecular connectivity) (2)(3)(4)(5). It was also higher in older men with low serum 25-hydroxycholecalciferol (25OHD) concentration (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study

Chaitou

Boutroy²,

Vilayphiou³

et al. 2011

European Journal of Endocrinology

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Objective: In the elderly, vitamin D deficit, low calcium intake, and impaired bone microarchitecture are associated with higher risk of hip fracture. We assessed the association of bone microarchitecture with calcium intake and serum concentrations of 25-hydroxycholecalciferol (25OHD) and parathyroid hormone (PTH) in men. Design: Cross-sectional analysis was performed in 1064 men aged 20-87 years not taking vitamin D or calcium supplements. Methods: Daily calcium intake was assessed using a food frequency questionnaire. Bone microarchitecture was assessed at distal radius and tibia by high-resolution peripheral quantitative computed tomography. We measured serum and urinary levels of biochemical bone turnover markers (BTMs). Statistical models were adjusted for age, weight, height, and glomerular filtration rate. Results: In 500 men aged !65 years, lower 25OHD levels and low calcium intake were associated with lower trabecular volumetric bone mineral density (Dtrab) at the distal tibia, due to lower trabecular number (Tb.N). Low calcium intake was associated with lower cortical thickness (Ct.Th). Higher PTH level was associated with higher BTM levels. In 563 men aged R65 years, the highest PTH quartile was associated with lower Ct.Th (tibia), lower Dtrab (both sites), and lower Tb.N (radius) compared with the lowest quartile. Low calcium intake was associated with lower Tb.N and more heterogenous trabecular distribution. BTM positively correlated with the PTH concentration. Conclusion: In older men, elevated PTH concentration is associated with high bone turnover, poor trabecular microarchitecture (radius and tibia), and, at the distal tibia, lower Ct.Th. Low calcium intake is associated with lower Tb.N and more heterogenous trabecular distribution.European Journal of Endocrinology 165 151-159

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“…Bone structure as a cause of OA 2.1 Bone micro-architecture in OA Changes in the microstructure of bone in OA, particularly the subchondral plate and the trabecular bone, have been well described (Madry et al, 2010;Fazzalari and Parkinson, 1998, Shen et al, 2009, Blain et al, 2008. In human OA subjects, changes consistently include thicker trabeculae and a higher trabecular BV/TV than for normal or osteoporotic subchondral bone.…”

mentioning

confidence: 99%

Subchondral Bone in Osteoarthritis

Findlay¹

2012

Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition

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Cortical and trabecular bone distribution in the femoral neck in osteoporosis and osteoarthritis

Cited by 79 publications

References 44 publications

Bone Microarchitecture of the Talus Changes With Aging

Bone Microarchitecture of the Talus Changes With Aging

Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study

Subchondral Bone in Osteoarthritis

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