Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study

Chaitou, Ali R; Boutroy, Stéphanie; Vilayphiou, Nicolas; Varennes, Annie; Richard, Michel; Blaizot, Stéphanie; Munoz, F.; Delmas, Pierre D.; Goudable, J.; Chapurlat, Roland; Szulc, Paweł

doi:10.1530/eje-11-0184

Cited by 38 publications

(44 citation statements)

References 43 publications

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“…Intra-and interassay coefficients of variation (CV) were \10 %. Serum testosterone, 17b-estradiol (17b-E 2 ), sex hormone-binding globulin (SHBG), 25-hydroxyvitamin-D (25OHD), and parathyroid hormone (PTH) were measured as described previously [25][26][27][28]. Apparent free testosterone concentration (AFTC) and bioavailable 17b-E 2 (bio-17b-E 2 ) were calculated [29].…”

Section: Biochemical Measurementsmentioning

confidence: 99%

Poor Trabecular Microarchitecture at the Distal Radius in Older Men with Increased Concentration of High-Sensitivity C-Reactive Protein—The Strambo Study

et al. 2012

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Low-grade inflammation, assessed by serum high-sensitivity C-reactive protein (hsCRP) concentration, is associated with higher fracture risk irrespective of areal bone mineral density (aBMD). We assessed the association of hsCRP with bone microarchitecture (measured by high-resolution pQCT) at the distal radius and tibia in 1,149 men, aged 19-87 years. hsCRP concentration increased with age until the age of 72, then remained stable. aBMD was not correlated with hsCRP level. After adjustment for confounders, bone microarchitecture was not associated with hsCRP level in men aged <72. After the age of 72, hsCRP >5 mg/L was associated with lower trabecular density, lower trabecular number, higher trabecular spacing, and more heterogeneous trabecular distribution (p < 0.05-0.005) at the distal radius versus hsCRP ≤ 5 mg/L. Similar differences were found for the fourth hsCRP quartile (>3.69 mg/L) versus the three lower quartiles combined. Cortical parameters of distal radius and microarchitectural parameters of distal tibia did not vary according to hsCRP concentration in men aged ≥ 72. Fracture prevalence increased with increasing hsCRP level. After adjustment for confounders (including aBMD), odds for fracture were higher in men with hsCRP >5 mg/L compared to hsCRP <1 mg/L (OR = 2.22, 95 % CI 1.29-3.82) and did not change after additional adjustment for microarchitectural parameters. The association between hsCRP level and bone microarchitecture was observed only for trabecular parameters at the radius in men aged ≥72. Impaired bone microarchitecture does not seem to explain the association between elevated CRP level and higher risk of fracture.

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Section: Biochemical Measurementsmentioning

confidence: 99%

Poor Trabecular Microarchitecture at the Distal Radius in Older Men with Increased Concentration of High-Sensitivity C-Reactive Protein—The Strambo Study

et al. 2012

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“…Serum levels of calcium, phosphate, and creatinine were measured using standard methods as described previously (24). 25OHD was measured with a RIA after acetonitrile extraction (DiaSorin, Stillwater, MN, USA) (24).…”

Section: Serum Measurementsmentioning

confidence: 99%

“…25OHD was measured with a RIA after acetonitrile extraction (DiaSorin, Stillwater, MN, USA) (24). Serum osteoprotegerin (OPG) was measured by ELISA (Biomedica, Vienna, Austria) (25).…”

Section: Serum Measurementsmentioning

confidence: 99%

Serum myostatin levels are negatively associated with abdominal aortic calcification in older men: the STRAMBO study

Szulc¹,

Hofbauer²,

Rauner³

et al. 2012

European Journal of Endocrinology

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Objective: To assess the association between abdominal aortic calcification (AAC) and serum levels of myostatin, a negative regulator of skeletal muscle mass, which has been implicated in the development of atherosclerotic lesions in mice. Design and patients: We assessed AAC semiquantitatively from the lateral spine scans obtained using dual energy X-ray absorptiometry in 1071 men aged 20-87 years. Serum myostatin levels were measured by an immunoassay that detects all myostatin forms. Results: Total myostatin serum levels did not differ between men with or without self-reported ischemic heart disease, hypertension, or diabetes mellitus. Total serum myostatin levels were higher in men with higher serum calcium levels and lower in men with higher serum concentrations of highly sensitive C-reactive protein. Men with AAC had lower myostatin levels compared with men without AAC. Prevalence of AAC (AAC score O0) was lower in the highest myostatin quartile compared with the three lower quartiles (P!0.05). After adjustment for confounders, odds of AAC (AAC score O0) were lower (ORZ0.62; 95% confidence interval (95% CI), 0.45-0.85; P!0.005) for the fourth myostatin quartile vs the three lower quartiles combined. In the sub-analysis of 745 men aged R60 years, the results were similar: AAC prevalence was lower in the highest myostatin quartile compared with the three lower quartiles combined (ORZ0.54; 95% CI, 0.38-0.78; P!0.001). Conclusions: In older men, total myostatin serum levels are inversely correlated with AAC. Further studies are needed to investigate mechanisms underlying this association and to assess utility of myostatin as a cardiovascular marker.

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“…Serum 25-hydroxycholecalciferol (25OHD) was measured by radioimmunoassay (RIA) after acetonitrile extraction (DiaSorin, Stillwater, MN) [22]. Serum parathyroid hormone (PTH) was measured by a human-specific immunochemiluminescence assay (ELECSYS; Roche Diagnostics, Mannheim, Germany) [23]. Serum testosterone was measured by a tritiated RIA after diethylether extraction [24].…”

Section: Serum Measurementsmentioning

confidence: 99%

Serum fetuin-A levels and abdominal aortic calcification in healthy men — The STRAMBO study

Schoppet

Rauner

Benner³

et al. 2015

Bone

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Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study

Cited by 38 publications

References 43 publications

Poor Trabecular Microarchitecture at the Distal Radius in Older Men with Increased Concentration of High-Sensitivity C-Reactive Protein—The Strambo Study

Poor Trabecular Microarchitecture at the Distal Radius in Older Men with Increased Concentration of High-Sensitivity C-Reactive Protein—The Strambo Study

Serum myostatin levels are negatively associated with abdominal aortic calcification in older men: the STRAMBO study

Serum fetuin-A levels and abdominal aortic calcification in healthy men — The STRAMBO study

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