Corrigendum: Total Synthesis of Pulvomycin D

Abstract

In Scheme3 of this Research Article,t he triethylsilyl groups in structures 14, 16, 18 and 19 were incorrectly labelleda s" SET" rather than "TES". The corrected Scheme 3 is given below.Scheme3.Synthesis of the C1-C7 fragment 20 of pulvomycin Df rom iodide 14 and Weinreba mide 15.Conditionsfor the Pinnick-Lindgren oxidation: [26] NaOCl,N aH 2 PO 4 ,2 -methyl-2-butene, r.t. (tert-butanol/H 2 O = 1/1)

Site-directed late-stage diversification of macrocyclic nannocystins facilitating anticancer SAR and mode of action studies

“…To our delight, the ring closure product turned out solely as an 8 E stereoisomer, thus adding to the robustness of Heck cross-coupling in macrocycle synthesis. 46–51 Final removal of the TBS group led smoothly to 8 in 90% yield. Advancing to the second stage (Scheme 1), 8 reacted separately with different acyl donors such as acid anhydrides (for 9a and 9d ), acyl chlorides (for 9b and 9c ), and carboxylic acids (for 9e–9n ), under three coupling conditions (see the table inset in Scheme 1; also refer to the experimental section for synthetic details).…”