Corrigendum to “In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazine derivatives of coumarin and chromone” [Eur J Med Chem 41 (11) (2006) 1301–1309]

3-Formylchromone Interacts with Cysteine 38 in p65 Protein and with Cysteine 179 in IκBα Kinase, Leading to Down-regulation of Nuclear Factor-κB (NF-κB)-regulated Gene Products and Sensitization of Tumor Cells

“…While searching for such agents, we focused on chromones, which have been linked with antibacterial, antifungal, and antitumor activities (1). In particular, we focused on 3-formylchromone (3-FC), 3 which has been shown to exhibit antibacterial (2), anti-inflammatory (3), and antitumor (2, 4 -6) activities. How this agent exhibits all these activities is not fully understood, but inhibition of protein-tyrosine phosphatase 1B (7), chelation of bivalent cations (8), multidrug resistance (5), p56 lck tyrosine kinase (9), and thymidine phosphorylase (10) have been implicated.…”

Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1,2,4-triazoles, 1,2,4-triazines and 1,2,4-triazepines ring systems

“…Thus, cyclocondensation of 4 with 6-chloro-3-formylchromone (1) in DMF under reflux containing few drops of piperidine afforded the 1,2,3,5-tetrahydro [1,2,4] triazolo [1,5-a]pyridine derivative 7. Oxidation of the latter compound by ferric chloride in boiling DMSO yielded 2,7-bis(6-chloro-4-oxo-4H-chromen-3-yl)-5-oxo-1,5-dihydro-1,2,4-triazolo [1,5-a] pyridine-6,8-dicarbonitrile (9). Compound 9 was also obtained by refluxing 4 with 6-chloro-chromone-3-carboxylic acid (8) in phosphorus oxychloride (Scheme 3).…”

“…[1][2][3] These synthesized and isolated derivatives were found to have a wide range of biological properties including antiinflammatory, 4 analgesic, 5 antimicrobial, 6-8 antitumor 9 and anticancer. 10 Pyridines are an important class of heterocycles due to their practical and synthetic applications.…”

3-Formylchromones as diverse building blocks in heterocycles synthesis

“…Treatment of 3-formylchromone 1a with substituted hydrazines 222a-c in absolute ethanol or toluene afforded the corresponding hydrazones 223a-c (Scheme 104) [152,153].…”