3-Formylchromones as diverse building blocks in heterocycles synthesis

Synthesis of imidazo[1,2-a]pyridin-chromones by a MW assisted Groebke–Blackburn–Bienaymé process

“…For example the 3-formylchromone is an excellent 1,2 and 1,4 acceptor. 6 This feature make it a suitable carbonylic reagent for multicomponent reactions (MCR), 7 which are one pot processes with a wide range of applications mainly in both, diversity oriented synthesis and combinatorial chemistry. 8…”

Crystal structure of (3,5-dichloro-2-hydroxyphenyl){1-[(naphthalen-1-yl)carbonyl]-1H-pyrazol-4-yl}methanone

“…3-Formylchromones are used as diverse building blocks (Ali et al, 2013), and their Schiff base derivatives have attracted much attention in medicinal chemistry (Nawrot-Modranka et al, 2006;Khan et al, 2009;Wang et al, 2008;Tu et al, 2013;Gaspar et al, 2014). We have recently reported the crystal structures of such Schiff base compounds (Ishikawa & Watanabe, 2014a,b,c,d), which were prepared from condensation reactions of 3-formylchromones with arylhydrazides.…”

Mechanochemical Defluorinative Acylation of ortho‐Hydroxyarylenaminones by CF3‐Compounds: Synthesis of 3‐Acylchromones

“…[18,19] From a synthetic point of view, 3-acylchromones are valuable precursors serving as electrophiles in 1,3nucleophilic addition, usually followed by pyrone ringopening, with subsequent cyclisation reactions yielding various (hetero)cyclic scaffolds, e. g. 2-hydroxybenzophenones, 6H-benzo[c]chromenes and benzo[c]coumarins. [20][21][22][23][24][25] Since 3-acylchromones are present in nature only scarcely (as metabolites of some plants [26] and fungi [27,28] ), it is thus necessary to develop facile and efficient synthetic protocols towards these compounds, enabling further study of their pharmacological properties as well as easy access to the valuable synthetic intermediates.…”