Corrigendum to “Gmelina arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats”

Attanayake, Anoja Priyadarshani; Jayatilaka, Kamani Ayoma Perera Wijewardana; Pathirana, Chitra; Mudduwa, Lakmini

doi:10.1155/2018/9861243

Cited by 4 publications

(6 citation statements)

References 2 publications

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“…The antihyperglycemic activity was evident through a significant reduction ( p < 0.05) in fasting blood glucose concentration, percentage of glycated hemoglobin, and serum concentration of fructosamine as 37%, 31%, and 28%, respectively. The same study also showed the significant improvement ( p < 0.05) of serum insulin and C -peptide as 57% and 39%, respectively, in streptozotocin-induced diabetic rats upon the treatment of aqueous extract of G. arborea bark at the dose of 1.00 g/kg for 30 days [ 93 ]. An increased production of insulin might be responsible for its antidiabetic mechanism in vivo [ 93 ].…”

Section: Resultsmentioning

confidence: 95%

“…The same study also showed the significant improvement ( p < 0.05) of serum insulin and C -peptide as 57% and 39%, respectively, in streptozotocin-induced diabetic rats upon the treatment of aqueous extract of G. arborea bark at the dose of 1.00 g/kg for 30 days [ 93 ]. An increased production of insulin might be responsible for its antidiabetic mechanism in vivo [ 93 ]. In addition, the antihyperlipidemic activity was also proven for the decoction of G. arborea bark (1.00 g/kg for 30 days) in streptozotocin-induced rats based on the changes in the lipid profile parameters [ 93 ].…”

Section: Resultsmentioning

confidence: 95%

“…The hot water extract of G. arborea bark showed a significant ( p < 0.05) percentage improvement on glucose tolerance by 18.42% at the dose of 1.00 g/kg in streptozotocin-induced diabetic Wistar albino rats [ 45 ]. The administration of aqueous extract of G. arborea bark (at the optimum dose of 1.00 g/kg) for 30 days showed the antihyperglycemic activity in streptozotocin-induced diabetic rats [ 93 ]. The antihyperglycemic activity was evident through a significant reduction ( p < 0.05) in fasting blood glucose concentration, percentage of glycated hemoglobin, and serum concentration of fructosamine as 37%, 31%, and 28%, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…An increased production of insulin might be responsible for its antidiabetic mechanism in vivo [ 93 ]. In addition, the antihyperlipidemic activity was also proven for the decoction of G. arborea bark (1.00 g/kg for 30 days) in streptozotocin-induced rats based on the changes in the lipid profile parameters [ 93 ]. The in vitro antioxidant activity of the decoction of G. arborea bark and methanol extracts of stem bark of G. arborea were investigated using DPPH, FRAP, and NO inhibition assays [ 94 ].…”

Section: Resultsmentioning

confidence: 99%

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Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

Wasana

Attanayake

Jayatilaka

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The use of medicinal plant extracts and their isolated bioactive compounds for the management of diabetes mellitus has been tremendously increased in recent decades. The present study aimed at providing in-depth information on medicinal flora that has been widely used in the Sri Lankan traditional healthcare system for the management of diabetes mellitus. The data of this review article were obtained from published articles from January 2000 to September 2020 in scientific databases of PubMed, Web of Science, and Google Scholar. In this review, a total number of 18 medicinal plants with the antidiabetic activity were expressed, and their isolated antidiabetic active compounds were highlighted as new drug leads. Results of the reported studies revealed that medicinal plants exert a potent antidiabetic activity via both in vitro and in vivo study settings. However, bioactive compounds and antidiabetic mechanism (s) of action of many of the reported medicinal plants have not been isolated/elucidated the structure in detail, to date. Reported antidiabetic medicinal plants with other properties such as antioxidant and antihyperlipidemic activities deliver new entities for the development of antidiabetic agents with multiple therapeutic targets. This is a comprehensive review on potential antidiabetic activities of the Sri Lankan medicinal plants that have been widely used in the traditional healthcare system. The information presented here would fill the gap between the use of them by traditional healers in the traditional medicine healthcare system in Sri Lanka and their potency for development of new drug entities in future.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

Wasana

Attanayake

Jayatilaka

et al. 2021

Evidence-Based Complementary and Alternative Medicine

Self Cite

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“…The stem bark extract (1.00g/kg) of plant G. arborea has been used for regeneration of -cells of the pancreas in diabetic rats and serum lipid parameters are reported to get improved in G. arborea extract treated to diabetic rats [88].…”

Section: Used For -Cell Regenerationmentioning

confidence: 99%

Gmelina arborea: chemical constituents, pharmacological activities and applications

Arora¹,

Tamrakar²

2017

ijpm

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Gmelina arborea (G. arborea) is a bio-prospective plant belonging to family verbenaceae. It is widely used for it’s medicinal properties from ancient times. The present paper comprehensively reviewed the traditional uses, medicinal properties and chemical constituents isolated from G. arborea based on literature reported as well as critical analysis of the research. The present article is aimed to provide information on recent advances and new foundations and direction for further exploring G. arborea for its applications. Pharmacological research reviewed that G. arborea possess various medicinal properties and biological activities including antidiuretic, antidiarrhoeal, antipyretic, antianalgesic, antioxidant, antidiabetic, antihelmintic, antibacterial, antifungal, cardiopotective, insecticidal, antiulcer, gastro-protective, anticancer, antihyperlipidemic and immunomodulatory activity. It has been reported for its applications in treatment of bone fracture, hypertension and regeneration of β-cells. The main chemical constituents of G. arborea include lignans, iridoid glycoside, flavonoids, flavons, flavone glycoside and sterols. The present review provides all the references and beneficial directions to explore further application of G. arborea.

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Antidiabetic Potential of Medicinal Plants and Their Active Components

et al. 2019

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Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.

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Corrigendum to “Gmelina arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats”

Cited by 4 publications

References 2 publications

Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

<em>Gmelina arborea</em>: chemical constituents, pharmacological activities and applications

Antidiabetic Potential of Medicinal Plants and Their Active Components

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