Corrigendum to “Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E2 and F2α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Diabetes”

Al-Matubsi, Hisham Y.; Oriquat, Ghaleb A.; Abu-Samak, Mahmoud; Hanbali, Othman A. Al; Salim, M.

doi:10.1155/2017/8135610

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…The administration of ALA significantly elevated COX-2 mRNA levels in the fibrotic lung and subsequently increased the level of PGE2 in the lung tissue. According to Al-Matubsi et al [43], administration of ALA increases the Activities of COX2 in the Offspring of Rats with Streptozotocin-Induced Diabetes. Also, administration of ALA (20 mg) increases the expression of COX2 in brain tissue suffered from acute ischemic stroke [44].…”

Section: Discussionmentioning

confidence: 99%

Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats

Elhadidy

Elmasry

Elsayed

et al. 2021

Heliyon

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This study aimed to explore the potential protective effect of α-lipoic acid on busulfan-induced pulmonary fibrosis in rats.Main methods: Eighteen adult male rats were divided into 3 groups; control, busulfan, and busulfan plus α-lipoic acid groups. Lung index ratio, serum level of proinflammatory cytokine were assessed. The activities of antioxidant enzymes and lipid peroxidation products were estimated in the lung tissues in addition to the histopathological analyses. The deposition of the collagen in the lung tissues was evaluated by Sirius red staining. The expressions of α-smooth muscle actin (α-SMA), TNF-α, and Caspase 3 were determined immunohistochemically.The pulmonary expression of COX-2 and NOX-4 mRNA was assessed using qRT-PCR. Key findings: Administration of ALA significantly protect the lung against BUS-induced pulmonary fibrosis, besides the upregulation of antioxidants, and downregulation of pro-inflammatory cytokines. Also, it reduced collagen deposition that associated with a decreased expression of α-SMA, TNF-α, and Caspase 3 in the lung tissues.Moreover, ALA significantly upregulated the expression of COX-2 concomitant with the downregulation of elevated NOX-4. Significance: ALA attenuates the lung cytotoxicity of busulfan through its anti-inflammatory, anti-apoptotic, and antifibrotic effects that may be mediated by upregulation of COX-2 and downregulation of NOX-4.

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Section: Discussionmentioning

confidence: 99%

Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats

Elhadidy

Elmasry

Elsayed

et al. 2021

Heliyon

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“…Group I (negative control group): included seven rats received an intraperitoneal injection of saline. Group II (positive control group): included seven rats received ALA by intraperitoneal injection at a dose of 30 mg/kg body weight in Tris buffer (pH = 7.4) between gestational days 0 and 15 [ 15 ]. Group III (VPA-treated group): included seven pregnant rats; received valproic acid at a single dose of 600 mg/kg (6 mL/kg body weight) by intraperitoneal injection on day 13 of gestation [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Ghoneim

Alrefai

Elsamanoudy

et al. 2020

Biology

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Background: Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration of VPA on the pancreas of rat offspring and assess the potential protective role of ALA co-administration during pregnancy. Methods: Twenty-eight pregnant female albino rats were divided into four groups: group I (negative control), group II (positive control, ALA treated), group III (VPA-treated), and group IV (VPA-ALA-treated). The pancreases of the rat offspring were removed at the fourth week postpartum and prepared for histological, immune-histochemical, morphometric, molecular, and oxidative stress marker studies. Results: In group III, there were pyknotic nuclei, vacuolated cytoplasm with ballooning of acinar, α, and β cells of the pancreas. Ultrastructural degeneration of cytoplasmic organelles was detected. Additionally, there was a significant increase in oxidative stress, a decrease in insulin-positive cell percentage, and an increase in glucagon positive cells in comparison to control groups. Moreover, VPA increased the gene expression of an apoptotic marker, caspase-3, with a decrease in anti-apoptotic Bcl2 and nuclear factor erythroid 2-related factor 2 (Nrf2) transcriptional factor. Conversely, ALA improved oxidative stress and apoptosis in group VI, and a consequent improvement of the histological and ultrastructure picture was detected. Conclusion: ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2. Administration of α-lipoic acid has a protective effect against VPA-induced pancreatic oxidative damage via its cytoprotective antioxidant effect.

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“…In the article titled “Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E 2 and F 2 α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Diabetes” [ 1 ], affiliation number three was incorrect. The correct affiliation list is shown above.…”

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confidence: 99%

Corrigendum to “Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E₂ and F₂α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Diabetes”

Al-Matubsi

Oriquat

Abu-Samak

et al. 2017

Journal of Diabetes Research

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Corrigendum to “Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E₂ and F₂α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Diabetes”

Cited by 3 publications

References 2 publications

Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats

Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats

The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Corrigendum to “Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E₂ and F₂α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Diabetes”

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