[Corrigendum] Cancer‑related fatigue during combined treatment of androgen deprivation therapy and radiotherapy is associated with mitochondrial dysfunction

Feng, Linyin; Wolff, Brian S.; Liwang, Josephine; Regan, Jeniece; Alshawi, Sarah; Raheem, Sumiyya; Saligan, Leorey N.

doi:10.3892/ijmm.2020.4546

Cited by 9 publications

(4 citation statements)

References 53 publications

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“…Herein, we showed that patient-reported fatigue was associated with lower overall mitochondrial function, namely lower basal respiration, lower maximal respiration, and a lower spare capacity in circulating T cells. There have been nine studies to our knowledge probing mitochondrial function in the context of cancer-related fatigue in various cell types [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. Six of these studies looked at associations between mitochondrial function and fatigue during treatment from radiotherapy [ 58 , 59 , 60 , 61 , 63 , 64 ], one enrolled patients initiating anthracycline- or taxane-based chemotherapy [ 62 ], and one recruited breast cancer survivors who underwent a variety of antineoplastic treatments [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

“…There have been nine studies to our knowledge probing mitochondrial function in the context of cancer-related fatigue in various cell types [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. Six of these studies looked at associations between mitochondrial function and fatigue during treatment from radiotherapy [ 58 , 59 , 60 , 61 , 63 , 64 ], one enrolled patients initiating anthracycline- or taxane-based chemotherapy [ 62 ], and one recruited breast cancer survivors who underwent a variety of antineoplastic treatments [ 65 ]. Collectively, these studies show that fatigue was associated with less mtDNA [ 62 ], downregulated mitochondrial gene expression [ 59 , 61 ], and less complex III-linked respiration [ 60 , 61 ], but no changes in the activity of mitochondrial oxidative phosphorylation complex enzymes [ 63 ], all in circulating blood cells.…”

Section: Discussionmentioning

confidence: 99%

“…Oxygen consumption rate (pmol/min/200,000 cells) was estimated at baseline and after each injection by averaging the three measurements (Wave Software, Agilent). Baseline respiration, maximal respiratory capacity, and spare capacity were calculated using established procedures [ 64 , 72 ].…”

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confidence: 99%

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The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

Kleckner

Reschke

Kleckner

et al. 2022

Cancers

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Cancer-related fatigue is a common, burdensome symptom of cancer and a side-effect of chemotherapy. While a Mediterranean Diet (MedDiet) promotes energy metabolism and overall health, its effects on cancer-related fatigue remain unknown. In a randomized controlled trial, we evaluated a rigorous MedDiet intervention for feasibility and safety as well as preliminary effects on cancer-related fatigue and metabolism compared to usual care. Participants had stage I–III cancer and at least six weeks of chemotherapy scheduled. After baseline assessments, randomization occurred 2:1, MedDiet:usual care. Measures were collected at baseline, week 4, and week 8 including MedDiet adherence (score 0–14), dietary intake, and blood-based metabolic measures. Mitochondrial respiration from freshly isolated T cells was measured at baseline and four weeks. Participants (n = 33) were 51.0 ± 14.6 years old, 94% were female, and 91% were being treated for breast cancer. The study was feasible, with 100% completing the study and >70% increasing their MedDiet adherence at four and eight weeks compared to baseline. Overall, the MedDiet intervention vs. usual care had a small-moderate effect on change in fatigue at weeks 4 and 8 (ES = 0.31, 0.25, respectively). For those with a baseline MedDiet score <5 (n = 21), the MedDiet intervention had a moderate-large effect of 0.67 and 0.48 at weeks 4 and 8, respectively. The MedDiet did not affect blood-based lipids, though it had a beneficial effect on fructosamine (ES = −0.55). Fatigue was associated with mitochondrial dysfunction including lower basal respiration, maximal respiration, and spare capacity (p < 0.05 for FACIT-F fatigue subscale and BFI, usual fatigue). In conclusion, the MedDiet was feasible and attenuated cancer-related fatigue among patients undergoing chemotherapy, especially those with lower MedDiet scores at baseline.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

Kleckner

Reschke

Kleckner

et al. 2022

Cancers

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“…The etiology of treatment-related fatigue has been subject to various hypotheses, but the precise underlying mechanism remains unidentified. One theory is that testosterone protects mitochondrial function and its dearth leaves brain cells vulnerable to oxidative stress and other sources of mitochondrial damage [145][146][147].…”

Section: Adt and Fatiguementioning

confidence: 99%

Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood

Reiss,

Gulkarov,

Pinkhasov

et al. 2023

Medicina

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Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer’s disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs. A comparative analysis of prostate cancer patients undergoing ADT and Alzheimer patients identified over 30 shared genes, illustrating common ground for the mechanistic underpinning of the symptomatology. The purpose of this review was to investigate the effects of ADT on cognitive function, mood, and quality of life, as well as to analyze the relationship between ADT and Alzheimer’s disease. The evaluation of prostate cancer patient cognitive ability via neurocognitive testing is described. Future studies should further explore the connection among cognitive deficits, mood disturbances, and the physiological changes that occur when hormonal balance is altered.

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Mitochondrial metabolism: a predictive biomarker of radiotherapy efficacy and toxicity

Taghizadeh‐Hesary

Houshyari

Farhadi

2023

J Cancer Res Clin Oncol

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[Corrigendum] Cancer‑related fatigue during combined treatment of androgen deprivation therapy and radiotherapy is associated with mitochondrial dysfunction

Cited by 9 publications

References 53 publications

The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood

Mitochondrial metabolism: a predictive biomarker of radiotherapy efficacy and toxicity

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