Corrigendum: Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?

Zoran, Tamara; Sartori, Bettina; Sappl, Laura; Aigner, Maria; Sánchez-Reus, Ferran; Rezusta, Antonio; Chowdhary, Anuradha; Taj-Aldeen, Saad J.; Arendrup, Maiken Cavling; Oliveri, Salvatore Massimo; Kontoyiannis, Dimitrios P.; Alastruey‐Izquierdo, Ana; Lagrou, Katrien; Cascio, Giuliana Lo; Meis, Jacques F.; Buzina, Walter; Farina, Claudio; Drogari‐Apiranthitou, Maria; Grancini, Anna; Tortorano, A.M.; Willinger, Birgit; Hamprecht, Axel; Johnson, Elizabeth; Klingspor, Lena; Arsić-Arsenijević, Valentina; Cornely, Oliver A.; Meletiadis, Joseph; Prammer, Wolfgang; Tullio, Viviana Cristina; Vehreschild, Jörg Janne; Trovato, Laura; Lewis, Russell E.; Segal, Esther; Rath, Peter; Hamal, Petr; Rodríguez-Iglesias, Manuel; Roilides, Emmanuel; Arıkan-Akdağlı, Sevtap; Chakrabarti, Arunaloke; Colombo, Arnaldo Lopes; Fernández, Mariana Soledad; Martín-Gómez, M Teresa; Badali, Hamid; Πετρίκκος, Γεώργιος; Климко, Н Н; Heimann, Sebastian; Uzun, Ömrüm; Roudbary, Maryam; Fuente, Sonia de la; Houbraken, Jos; Risslegger, Brigitte; Sabino, Raquel; Lass‐Flörl, Cornelia; Lackner, Michaela

doi:10.3389/fmicb.2018.03245

Cited by 3 publications

(2 citation statements)

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“…Research to define their distribution in the environment and their ecological niche and to determine their involvement in aspergillosis is needed. This is also the case for species of the section Terrei which in some regions show significant rates of resistance to posaconazole [ 49 ]. Finally, mucorales can also have a reduced sensitivity to triazoles (with a marked intrinsic resistance for some species), and it is therefore not impossible that these moulds can thrive in environments largely contaminated with triazoles.…”

Section: Discussionmentioning

confidence: 98%

Field-Crop Soils in Eastern France: Coldspots of Azole-Resistant Aspergillus fumigatus

Godeau

Morin‐Crini

Crini

et al. 2023

JoF

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Triazole fungicides are widely used to treat fungal pathogens in field crops, but very few studies have investigated whether fields of these crops constitute hotspots of azole resistance in Aspergillus fumigatus. Soil samples were collected from 22 fields in two regions of eastern France and screened for triazole residues and azole-resistant A. fumigatus (ARAf). Real-time quantitative PCR (qPCR) was used to quantify A. fumigatus in these soil samples. All the plots contained tebuconazole at concentrations from 5.5 to 19.1 ng/g of soil, and 5 of the 22 plots also contained epoxiconazole. Only a few fungal isolates were obtained, and no ARAf was detected. A. fumigatus qPCR showed that this fungal species was, on average, 5000 times more common in soil from flowerbeds containing ARAf than in soil from field crops. Thus, field-crop soils do not appear to promote A. fumigatus development, even if treated with azole fungicides, and cannot be considered hotspots of resistance. Indeed, our results suggest that they are instead a coldspot of resistance and highlight how little is known about the ecological niche of this species.

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Section: Discussionmentioning

confidence: 98%

Field-Crop Soils in Eastern France: Coldspots of Azole-Resistant Aspergillus fumigatus

Godeau

Morin‐Crini

Crini

et al. 2023

JoF

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“…In addition, acquired resistance is an emerging problem in Aspergillus species, especially against the azole class (12). Azole resistance is most commonly reported for A. fumigatus but is also observed in other species (17). In A. fumigatus, environmental exposure of the fungus to azole fungicides was found to be a major driver of resistance selection (18).…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Conidial Germination in Aspergillus spp

Baltussen

Zoll

Verweij

et al. 2020

Microbiol Mol Biol Rev

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SUMMARY Aspergilli produce conidia for reproduction or to survive hostile conditions, and they are highly effective in the distribution of conidia through the environment. In immunocompromised individuals, inhaled conidia can germinate inside the respiratory tract, which may result in invasive pulmonary aspergillosis. The management of invasive aspergillosis has become more complex, with new risk groups being identified and the emergence of antifungal resistance. Patient survival is threatened by these developments, stressing the need for alternative therapeutic strategies. As germination is crucial for infection, prevention of this process might be a feasible approach. A broader understanding of conidial germination is important to identify novel antigermination targets. In this review, we describe conidial resistance against various stresses, transition from dormant conidia to hyphal growth, the underlying molecular mechanisms involved in germination of the most common Aspergillus species, and promising antigermination targets. Germination of Aspergillus is characterized by three morphotypes: dormancy, isotropic growth, and polarized growth. Intra- and extracellular proteins play an important role in the protection against unfavorable environmental conditions. Isotropically expanding conidia remodel the cell wall, and biosynthetic machineries are needed for cellular growth. These biosynthetic machineries are also important during polarized growth, together with tip formation and the cell cycle machinery. Genes involved in isotropic and polarized growth could be effective antigermination targets. Transcriptomic and proteomic studies on specific Aspergillus morphotypes will improve our understanding of the germination process and allow discovery of novel antigermination targets and biomarkers for early diagnosis and therapy.

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Species Distribution and Antifungal Susceptibilities of Aspergillus Section Fumigati Isolates in Clinical Samples from the United States

et al. 2022

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Aspergillus species are capable of causing both invasive disease and chronic infections in immunocompromised patients or those with preexisting lung conditions. Aspergillus fumigatus is the most commonly cultured species, and there is increasing concern regarding resistance to the azoles, which are the mainstays of antifungal therapy against aspergillosis. We evaluated the species distribution and susceptibility profiles of isolates within Aspergillus section Fumigati in the United States over a 52-month period.

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Corrigendum: Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?

Cited by 3 publications

References 0 publications

Field-Crop Soils in Eastern France: Coldspots of Azole-Resistant Aspergillus fumigatus

Field-Crop Soils in Eastern France: Coldspots of Azole-Resistant Aspergillus fumigatus

Molecular Mechanisms of Conidial Germination in Aspergillus spp

Species Distribution and Antifungal Susceptibilities of Aspergillus Section Fumigati Isolates in Clinical Samples from the United States

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