Correspondence between ribosome aggregation patterns in rat liver homogenates and in electron micrographs following administration of ethionine

The Effects of Steroid Hormones and Carcinogens on the Interaction of Membranes with Polysomes

“…The importance of this type of interaction in the transformation of tissues in vivo is clearly impossible to evaluate at the present time but such an initial interaction in vivo is certainly consistent with the frequent reports of rough endoplasmic membrane degranulation (Baglio and Farber, 1965;Svoboda and Higginson, 1968;Flaks, 1970) and binding of carcinogens to cytoplasmic and microsomal protein (Miller and Miller, 1952;Wiest and Heidelberger, 1953;Hultin, 1956) …”

Endoplasmic membrane degranulationin vivo as a result of ethionine intoxication

“…those which remain in the 2.0 M sucrose layer and do not pellet during centrifugation. These data are clearly consistent with the observed degranulation in vivo [1] and the increase in the proportion of small polysomes and monomeric ribosomes [11] during ethionine intoxication. The exact correspondence between the loss of RNA from the membrane fraction and the increase in the slowly sedimenting RNA fraction suggests the possibility that the extra RNA in the latter fraction derives from polysomes removed from the membrane.…”

The ultrastructure of palmyrah (<em>Borassus flabellifer</em> L) - intoxicated mouse hepatocytes

“…The palmyrah-induced lesions bear a similarity to those observed in the rat liver in ethionine toxicity, both at the light and ultramicroscopical levels (3,4,5,6). It is currently believed that most of the hepatotoxic effects in acute ethionine poisoning are a result of low levels of cellular ATP.…”