Correlative Factors of Insulin Resistance in Essential Hypertension.

Tian, Hongliang; Ma, Aiqun; Chongmin, LI; Cheng, Mailing; Bai, Ling; Liu, Huasheng

doi:10.1291/hypres.23.265

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…The mechanism of insulin resistance in subjects with NASH may be related to levels of insulin-like growth factor, an independent affector of insulin sensitivity. [42][43][44][45] Free insulin-like growth factor levels were lower in patients with NASH than in either obese or lean controls in these experiments, although the differences did not reach statistical significance. The higher levels of nonessential fatty acids, ␤-hydroxybutyrate, and glycerol that were observed in this study in patients with NASH when compared with lean controls, despite higher circulating insulin levels, also point to insulin resistance.…”

Section: Discussioncontrasting

confidence: 54%

Apolipoprotein synthesis in nonalcoholic steatohepatitis

et al. 2002

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The pathophysiology of hepatic steatosis, a prerequisite of nonalcoholic fatty liver disease, is poorly understood. Because very-low-density lipoprotein (VLDL) formation is the chief route of hepatic lipid export, we hypothesized that the synthesis of apoB-100, a rate-determining step in hepatic VLDL formation, may be altered in patients with nonalcoholic steatohepatitis (NASH). This study evaluated the relative synthesis rates of apolipoprotein B-100 (apoB-100) in patients with NASH and in lean and body mass index (BMI)-matched (obese) controls without NASH. A primed continuous infusion of L-[1-13 C] leucine was used to measure the absolute synthesis rates (ASR) of apoB-100 and fibrinogen in 7 patients with NASH and compared them with 7 lean and 7 obese (BMI-matched) controls without NASH. The ASRs of fibrinogen and albumin also were measured. The mean ASR of apoB-100 in patients with NASH was lower (31.5 ؎ 3.4 mg/kg/d) than that of obese (115.2 ؎ 7.2 mg/kg/d, P < .001) and lean controls (82.4 ؎ 4.1 mg/kg/d, P ‫؍‬ .002). In contrast, the mean ASR of fibrinogen was greater in subjects with NASH than in both control groups. These data indicate that NASH is associated with markedly altered hepatic synthesis of apoB-100. The finding that albumin synthesis was not similarly decreased in patients with NASH shows that the attenuation of apoB-100 synthesis is not on the basis of globally impaired hepatic protein synthesis. In conclusion, because apoB-100 synthesis is a rate-determining step in hepatocyte lipid export, decreased synthesis of this protein may be an important factor in the development of hepatic steatosis, a prerequisite for NASH. (HEPATOLOGY 2002;35:898-904.) N on-alcoholic steatohepatitis (NASH; part of the spectrum of nonalcoholic fatty liver disease) is characterized by macrovesicular steatosis, nuclear glycogenation, lobular and portal inflammation, and, occasionally, Mallory's hyaline, in the absence of excessive alcohol ingestion. 1 NASH is most frequently associated with obesity 2-9 and type 2 diabetes mellitus. 3,[7][8][9] Despite the high prevalence and the increasingly recognized morbidity associated with NASH, little is known about the pathophysiology of this condition. The liver is central to the regulation of fat metabolism, and the net accumulation of fat within hepatocytes, a prerequisite for steatosis and steatohepatitis, could potentially result from alterations in the uptake, synthesis, degradation, or secretory pathways of hepatic lipid metabolism.Apolipoprotein B-100 (apoB-100) is a large protein (512 kd) involved in the transport of triglycerides and cholesterol from the liver to peripheral tissues. Lipids are chiefly exported from the liver in the form of very-lowdensity lipoproteins (VLDL), a complex of protein (apoB-100), lipids (triglycerides or cholesteryl esters), and phospholipids. Although the mechanisms regulating the synthesis of apoB-100 are incompletely understood, the production of apoB-100 messenger RNA (mRNA) has been shown to be altered by insulin and unaffected by...

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Section: Discussioncontrasting

confidence: 54%

Apolipoprotein synthesis in nonalcoholic steatohepatitis

et al. 2002

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“…Obesity is a major risk factor for hypertension that can be effectively controlled through exercise and diet, and control of obesity is recognized to have an important role in primary prevention of hypertension. The mechanism of the association between obesity and hypertension might be explained by the increase in leptin in obesity, the decrease in adiponectin, and in the development of insulin resistance [ 18 – 21 ]. This study used some of the main anthropometric assessment methods for obesity, including WC, BMI, WHR, and WHtR.…”

Section: Discussionmentioning

confidence: 99%

Anthropometric Indices Predict the Development of Hypertension in Normotensive and Pre-Hypertensive Middle-Aged Women in Tianjin, China: A Prospective Cohort Study

Wang

Yao

et al. 2018

Med Sci Monit

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BackgroundThe aims of this study were to investigate the relationship between optimal anthropometric indices and their cut-off values and the incidence of hypertension in a cohort of middle-aged women in China.Material/MethodsA cohort of 812 women, aged between 40–70 years were recruited between May 2011 and June 2013. An ideal baseline blood pressure was defined as <120/80 mmHg; pre-hypertension was 120–139/80–89 mmHg; hypertension was ≥140/≥90 mmHg. Anthropometric measurements included waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), and waist-height ratio (WHtR). The cohort was divided into an ideal blood pressure group (Group 1) and a pre-hypertensive group (Group 2). Two-year follow-up blood pressure measurements were performed. Receiver-operating characteristic (ROC) curve analysis determined the optimal anthropometric indices and cut-off values for developing hypertension.ResultsAt two-year follow-up, hypertension developed in 9.0% (n=31) in Group 1 and 32.3% (n=121) in Group 2. Logistic regression analysis showed that in both groups, women in the highest quartile for WC, BMI, WHR, and WHtR had a significantly increased risk of developing hypertension compared with the lowest quartile (P<0.05). ROC curve area under the curve (AUC) for these anthropometric indices were greater in Group 1, and for WC in Groups 1 and 2, with the optimal cut-off values greater in Group 1.ConclusionsIn a cohort of middle-aged women in China, anthropometric indices of obesity were predictive of the development of hypertension during a two-year follow-up period.

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“…Reduced IGF-1 and increased IGFBP-3 are thought to play important roles in the promotion of atherosclerosis via their opposing effects on growth, repair, and survival of vascular smooth muscle cells [74] . Reduced bioavailability of IGF-1 may also contribute to cardiovascular disease by altering carbohydrate and lipid metabolism [75][76][77] and by increasing blood pressure [78,79] , factors also associated with the development of preeclampsia [3,7] .…”

Section: Igf-1 and Igfbp-3mentioning

confidence: 99%

Altered Metabolic Profiles among Older Mothers with a History of Preeclampsia

Innes

Weitzel

Laudenslager

2005

Gynecol Obstet Invest

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Preeclampsia has been linked to increased risk for cardiovascular disease and, more recently, to reduced risk for breast cancer later in life. The altered chronic disease risk associated with prior preeclampsia may reflect underlying metabolic differences. In this case-control study, we examined the metabolic profiles of older mothers with and without a history of preeclampsia in their first pregnancies. At the time of the study, subjects were non-pregnant, non-smoking women who completed their first pregnancies at age 30 or older, were pre-menopausal, and were free of serious chronic disease. Cases were 13 women who experienced preeclampsia in their first pregnancies; controls were 13 women with uncomplicated first pregnancies, frequency matched to cases on race/ethnicity, current age, and age at delivery. A fasting blood sample was collected from each subject during the luteal phase (day 19–22) of the menstrual cycle and assayed for specific factors thought to be linked to hypertensive disease or breast cancer. Compared to women with uncomplicated pregnancies, those with a history of preeclampsia had significantly elevated levels of fasting serum triglycerides, insulin and glucose, and a higher fasting insulin resistance index, suggesting that women with prior preeclampsia were relatively insulin resistant. In addition, cases had higher levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) and a higher molar ratio of IGFBP-3 to IGF-1 than did controls. Adjustment for obesity and other potential confounders did not appreciably alter the magnitude of these associations. This preliminary study suggests that women with a history of preeclampsia have persistent metabolic abnormalities consistent with their observed excess risk for cardiovascular morbidity and mortality, and their apparent reduced risk for breast cancer later in life.

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Correlative Factors of Insulin Resistance in Essential Hypertension.

Cited by 10 publications

References 13 publications

Apolipoprotein synthesis in nonalcoholic steatohepatitis

Apolipoprotein synthesis in nonalcoholic steatohepatitis

Anthropometric Indices Predict the Development of Hypertension in Normotensive and Pre-Hypertensive Middle-Aged Women in Tianjin, China: A Prospective Cohort Study

Altered Metabolic Profiles among Older Mothers with a History of Preeclampsia

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