Correlations of placental vascular anatomy and clinical outcomes in 69 monochorionic twin pregnancies

Machin, Geoffrey A.; Still, Keith; Lalani, Tasneem

doi:10.1002/(sici)1096-8628(19960122)61:3<229::aid-ajmg6>3.0.co;2-p

Cited by 190 publications

(72 citation statements)

References 13 publications

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“…Approximately a third of MZ twins are DCMZ, and two thirds, MCMZ twins (Bulmer, 1970). The sharing of a chorion and a placenta, and the presence of vascular anastomoses between the circulations of the two fetuses allows exchange of blood, hormones, oxygen and other material between both members of the twin pair (Machin et al, 1996). For this reason, MCMZ twins can be more similar than DCMZ twins in postnatal development.…”

mentioning

confidence: 99%

Effects of the Chorion Type on Prosocial Behavior in Young South Korean Twins

Hur¹

2007

Twin Res Hum Genet

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The present study examined the possible effects of chorionicity of twins on variation of prosocial behavior in the classical twin design. Mothers of 56 pairs of monochorionic monozygotic (MCMZ) twins, 34 pairs of dichorionic monozygotic (DCMZ) twins, and 316 pairs of dizygotic (DZ) twins rated their children's prosocial behavior. The MCMZ correlation for prosocial behavior was similar to the DCMZ correlation (.63 vs. 61), but both correlations were higher than the DZ correlation (.33). Models incorporating the chorion effects were fit to the data. Genetic, shared and nonshared environmental, and chorion effects in the full model were, respectively, 53% (95% CI: 1–70%), 7% (95% CI: 0–37%) , 40% (95% CI: 29–54%), and 0% (95% CI: 0–27%), with the effects of chorion and shared environment being nonsignificant. These findings indicate that genetic and environmental factors in prosocial behavior estimated from twin studies are not significantly influenced by the chorion type of MZ twins.

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mentioning

confidence: 99%

Effects of the Chorion Type on Prosocial Behavior in Young South Korean Twins

Hur¹

2007

Twin Res Hum Genet

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“…The anastomoses may vary in number and type, that is, arterio-arterial, veno-venous or arterio-venous or a combination of these, and the variation affects the clinical outcome (Machin et al, 1996). The flow patterns across these anastomoses may be either balanced or imbalanced with adverse clinical outcomes predominantly being with the latter.…”

Section: Anomalies Attributable To the Type Of Placentationmentioning

confidence: 99%

Causal Hypothesis for Some Congenital Anomalies

Pharoah¹

2005

twin res hum genet

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“…La presencia de Aa-v, no compensada por Aa-a protectora (7), ante diferencia de presión intraplacentaria, origina transfusión unidireccional, de mal pronóstico perinatal y su expresión máxima es el Síndrome de Transfusión Gemelo-Gemelo (STGG) grave, presente en 15% de los casos y que tiene evolución letal (8,9).…”

Section: Introductionunclassified

Vía Del Nacimiento en Gemelar Monocoriónico Con Transfusión Intergemelar Y Terapia in Utero

2004

Rev. chil. obstet. ginecol.

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RESUMENEl propósito de la comunicación es revisar la vía del parto en embarazo gemelar complicado por Síndrome de Transfusión Gemelo-Gemelo (STGG) y por gemelo acardio con perfusión arterial reversa. La placentación del gemelar monocoriónico por sus anastomosis arteriales y venosas genera esas complicaciones que se asocian a una mortalidad cercana a 100% cuando no son tratadas en el período antenatal. Se describen dos casos de gemelar monocoriónico complicado, uno con STGG y otro, un acardio con perfusión reversa, ambos con diagnóstico ultrasónico precoz en primer trimestre y comienzo del segundo, que fueron exitosamente tratados in útero con coagulación láser sobre anastomosis vascular placentaria y sobre arteria umbilical pelviana obteniendo mejoría hemodinámica y recuperación de la funcionalidad placentaria. Se discuten aspectos generales del cuidado médico antenatal e intraparto del embarazo gemelar y específicamente del gemelar monocoriónico complicado. Se concluye que la terapia in útero fue exitosa además de mejorar el pronóstico puede favorecer la vía vaginal de parto.PALABRAS CLAVE: embarazo gemelar monocoriónico, anastomosis vasculares, terapia láser, parto vaginal SUMMARYThe aim of this communication is to review the way of delivering twin pregnancy complicated by either Twin to Twin Transfusion Syndrome (TTTS) or acardic twin with reverse arterial perfusion. The monochorionic placentae is characterised by superficial or deep vascular anastomosis which leads to the complications mentioned above, which are associated with almost 100% mortality when they are not treated antenatally. We describe two cases of severe TTTS and acardic twin with reverse arterial perfusion both diagnosed antenatally during the first and early second trimester of pregnancy on which laser treatment either on placental vascular anastomoses or pelvic single umbilical artery were done successfully. In addition of this we discuss some clinical aspects of prevention of premature delivery, antenatal and intrapartum medical care for twin pregnancy in general and specifically for complicated monochorionic twin pregnancy. We conclude that a successful fetal therapy improves pregnancy prognosis and makes possible vaginal delivery.

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Correlations of placental vascular anatomy and clinical outcomes in 69 monochorionic twin pregnancies

Cited by 190 publications

References 13 publications

Effects of the Chorion Type on Prosocial Behavior in Young South Korean Twins

Effects of the Chorion Type on Prosocial Behavior in Young South Korean Twins

Causal Hypothesis for Some Congenital Anomalies

Vía Del Nacimiento en Gemelar Monocoriónico Con Transfusión Intergemelar Y Terapia in Utero

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