Correlations of MTHFR 677C>T Polymorphism with Cardiovascular Disease in Patients with End-Stage Renal Disease: A Meta-Analysis

Abstract

ObjectiveThis meta-analysis was conducted to evaluate the correlations of a common polymorphism (677C>T) in the methylenetetrahydrofolate reductase (MTHFR) gene with risk of cardiovascular disease (CVD) in patients with end-stage renal disease (ESRD).MethodThe following electronic databases were searched without language restrictions: Web of Science (1945∼2013), the Cochrane Library Database (Issue 12, 2013), MEDLINE (1966∼2013), EMBASE (1980∼2013), CINAHL (1982∼2013) and the Chinese Biomedical Database (CBM) (1982∼2013). Meta-analysis was performed using STATA statistical software. Odds ratios (ORs) with their 95% confidence intervals (95%CIs) were calculated.ResultsEight cohort studies met all inclusion criteria and were included in this meta-analysis. A total of 2,292 ESRD patients with CVD were involved in this meta-analysis. Our meta-analysis results revealed that the MTHFR 677C>T polymorphism might increase the risk of CVD in ESRD patients (TT vs. CC: OR = 2.75, 95%CI = 1.35∼5.59, P = 0.005; CT+TT vs. CC: OR = 1.39, 95%CI = 1.09∼1.78, P = 0.008; TT vs. CC+CT: OR = 2.52, 95%CI = 1.25∼5.09, P = 0.010; respectively). Further subgroup analysis by ethnicity suggested that the MTHFR 677C>T polymorphism was associated with an elevated risk for CVD in ESRD patients among Asians (TT vs. CC: OR = 3.38, 95%CI = 1.11∼10.28, P = 0.032; CT+TT vs. CC: OR = 1.44, 95%CI = 1.05∼1.97, P = 0.022; TT vs. CC+CT: OR = 3.15, 95%CI = 1.02∼9.72, P = 0.046; respectively), but not among Africans or Caucasians (all P>0.05).ConclusionOur findings indicate that the MTHFR 677C>T polymorphism may be associated with an elevated risk for CVD in ESRD patients, especially among Asians.

Serum Homocysteine Levels and its Methylenetetrahydrofolate Gene (MTHFR) C677t Polymorphism in Patients with Hemodialysis

“…Additional studies, including prospective dietary intervention trials, could provide much needed information on these associations with survival. 26 Positive This meta-analysis included 3886 patients Jardine et al 27 Negative 10,951 participants in total Pena and Claro 28 Negative This work analyzed the papers from Qin et al 26 and Jardine et al 27 Levi et al 29 Positive A historical prospective study on 3602 subjects About the MTHFR C677T genotype, a meta-analysis of Gao et al 33 concluded that this polymorphism may be associated with an elevated risk for CVD in ESRD, especially among Asians. In contrast, our results did not put the presence of MTHFR C677T genotype as a strong determinant for mortality, at least in a short follow up of 1 year.…”

Potential Risk Factors Associated With Vascular Diseases in Patients Receiving Treatment for Hypertension

“…Factor V G1691A and prothrombin G20210A polymorphisms are the primary genetic risk factors of inherited thrombophilic disorders [ 9 10 ]. Furthermore, the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and homocysteine (Hcy) levels have been shown to be associated with coronary heart disease [ 11 12 13 ], venous thrombosis including DVT, and portal vein thrombosis [ 14 15 ]. MTHFR A1298C polymorphism is also reported to be associated with occlusive artery disease or DVT [ 16 ].…”

“…Therefore, clinical and laboratory factors associated with AVD or DVT should be reevaluated in patients receiving treatment for HTN. The importance of genetic predisposition, as well as existing traditional factors such as lipid profile, thrombotic biomarkers, and lifestyle, has recently been acknowledged [ 10 12 14 20 21 ]. Moreover, unmodifiable factors such as genetic predisposition may be emphasized in HTN patients receiving treatment.…”

Macrophage migration inhibitory factor –173G/C gene polymorphism increases the risk of renal disease: A meta‐analysis

“…Lan and colleagues showed that MIF expression is significantly upregulated in proliferative forms of human glomerulonephritis, and this is associated with histological damage, leukocyte infiltration and renal function impairment . Besides, lots of studies found that the host gene takes part in the pathogenesis of kidney disease . Recently, one polymorphism named −170G/C has been indentified in the MIF gene and it was closely associated with renal disease.…”

“…14 Besides, lots of studies found that the host gene takes part in the pathogenesis of kidney disease. 15,16 Recently, one polymorphism named −170G/C has been indentified in the MIF gene and it was closely associated with renal disease. Tripathi et al reported that MIF −173G/C gene variant could increase the risk of end-stage renal disease (ESRD).…”