Correlations of international cancer death rates.An epidemiological exercise

Wynder, Ernest L.; Hyams, Lyon; Shigematsu, Takao

doi:10.1002/1097-0142(1967)20:1<113::aid-cncr2820200117>3.0.co;2-o

Cited by 67 publications

(8 citation statements)

References 7 publications

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“…The earliest suggestion that hormones may play a role in colorectal cancer etiology came from cross-cultural data showing positive correlations between colon and breast cancer mortality rates (Wynder et al, 1967). A possible role for sex hormones in the risk of colorectal cancer has subsequently been supported by agehex differences in colorectal cancer incidence rates which are not consistent from country to country (Mc-Michael et al, 1985).…”

mentioning

confidence: 99%

The influence of parity and exogenous female hormones on the risk of colorectal cancer

Davis

Furner

Persky

et al. 1989

Intl Journal of Cancer

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Evidence that female sex hormones may play a role in the subsequent development of colorectal cancer has accumulated from time trends in colorectal cancer rates and from epidemiologic studies. Using data available from the Cross Cancer Institute Northern Alberta Cancer Program, the relationship of parity, exogenous hormones and colorectal cancer was evaluated. Five hundred and twenty-eight colon cancer and 192 rectal cancer cases were identified and 349 nonendocrine cancers were selected as controls. All subjects were diagnosed and interviewed between 1969 and 1973. Protective associations between previous pregnancies and colorectal cancer were found in women over age 50 at diagnosis (OR = 0.5, 95% CI = 0.3-0.9) and in women who never used exogenous hormones (OR = 0.3, 95% CI = 0.2-0.7). Results from this study provide additional support for earlier suggestions that parity may have a protective effect against the development of colorectal cancer, similar to the effects reported in the case of breast, endometrial and ovarian tumors.

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confidence: 99%

The influence of parity and exogenous female hormones on the risk of colorectal cancer

Davis

Furner

Persky

et al. 1989

Intl Journal of Cancer

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“…The susceptibility of the colon cancer patient to other forms of cancer is of some interest. Cancer of the colon in females has been reported t o be correlated (statistically) with breast cancer (Wynder et al, 1967;Paymaster and Gangadharan, 1972). This suggests that common etiological factors may be involved.…”

Section: Multiple Sitesmentioning

confidence: 75%

Cancer of the colon: 32 years of experience in Bombay, India

Jussawalla

Gangadharan

1977

Journal of Surgical Oncology

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Incidence rate of colon cancer is low in India compared to the Western countries. The dietary habits may be the protective factor in our population. During a 32 year period (1941-1972), 555 cases of colonic cancer were recorded at the Tata Memorial Hospital, Bombay. Among the social groups utilizing this hospital, the Parsis (Zoroastrians) have the highest incidence of colonic cancer. The frequency of cancer of the caecum and sigmoid are almost equal. Cancer of splenic and hepatic flexures are predominantly seen in men. Of the resected cases 50% survived for 5 years and 40% for 10 years. When cancer was localised, the 5 year survival rate was 64%. The 5 year survival rat among transverse colon cancer patients was 70%. The skin was the commonest site of a second cancer among colon cancer patients; the possible etiological association of these two cancers appears very intriguing.

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“…For instance, Wynder et a1. 35 I . I J J I I I 1 I I I I I L I I I I 1 1 1 1 1 1 1 1 we conclude that there is a real and close association between the rates of occurrence of cancers of the two sites as these sites traditionally are defined.…”

Section: Supplementmentioning

confidence: 81%

The geographic pathology of bowel cancer

Berg

Howell

1974

Cancer

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The most recent international data (for 1966–1967) show that Scotland still has the highest reported death rate from bowel cancer, despite a 20% reduction from the rate of 15 years earlier. The English death rates also dropped, while the rates for Japan, Italy, and West Germany rose appreciably. International data reinforce the recent case‐control observation that bowel cancer and beef consumption are closely associated. Comparison of incidence rates for colon and rectum show a generally close correlation, stronger than previously reported. The mathematical description of the association can be interpreted as saying that, while much rectal cancer is caused by the same factors that cause colon cancer, there is a second set of rectal cancers of different etiology. This hypothesis also is consistent with the differences in location of rectal cancers found in populations of low and high incidence. In particular, rectal cancer in the United States now tends to be upper rectal cancer, and only about 12% of U.S. bowel cancer is palpable on digital examination.

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Correlations of international cancer death rates.An epidemiological exercise

Cited by 67 publications

References 7 publications

The influence of parity and exogenous female hormones on the risk of colorectal cancer

The influence of parity and exogenous female hormones on the risk of colorectal cancer

Cancer of the colon: 32 years of experience in Bombay, India

The geographic pathology of bowel cancer

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