Correlations of IL-23R gene polymorphism with clinicopathological characteristics and prognosis of hepatocellular carcinoma patients after interventional therapy

Pan, Xin; Wang, Gang

doi:10.1016/j.ygeno.2018.05.023

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Given the high heterogeneity and malignance, the longterm outcome of HCC patients after surgical resection remained dismal. 21,[22][23][24] Recently, molecular treatment has potentially improved the survival rate of some cancers. 25 Comprehensive research of the molecular mechanisms associated with HCC progression was necessitated to reveal more precise targets for pharmaceutic therapy.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA

Zhang

Shen

et al. 2020

J of Cellular Biochemistry

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Kinesin family member 2C (KIF2C), a substantial mitotic regulator, has been verified to exert a malignant function in several cancers. However, its function in hepatocellular carcinoma (HCC) remains unclear. In this study, the expression profile of KIF2C in HCC was characterized through the dataset from the TCGA and clinical tissue microarrays containing 220 pairs of resected HCC tissues and adjacent nontumor tissues in our hospital. The results indicated that KIF2C was substantially higher expression in tumor tissues than adjacent nontumor tissues. High expression of KIF2C significantly correlated with large tumor (>5.0 cm) (P = .001) and implied a dismal postoperative overall survival (OS) (hazard ratio [HR] = 1.729; P = .002) in our cohort of patients. Gain and loss of function assays displayed that KIF2C promoted HCC cell proliferation, accelerated cell cycle progression, and impeded apoptosis. By bioinformatic tools and mechanistic investigation, we found that KIF2C interacted with various cell‐cycle‐related proteins and was significantly involved in growth‐promoting pathways. KIF2C upregulated PCNA and CDC20 expression. Subsequently, we investigated the regulation of KIF2C by competing endogenous RNA and elucidated that has‐miR‐6715a‐3p was directly bond to the 3′‐untranslated region of KIF2C through dual luciferase assays, thereby inhibiting KIF2C expression. Furthermore, the long noncoding RNA GS1‐358P8.4 was found to be a candidate of KIF2C for has‐miR‐6715a‐3p binding. HCC patients with high lncRNA‐GS1‐358P8.4 expression had shorter OS and relapse‐free survival compared to those with low expression, which was accordance with the KIF2C. Taken together, KIC2C aggravated HCC progression, it could serve as a prognostic indicator and confer a novel target for clinical treatment.

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Section: Discussionmentioning

confidence: 99%

Retracted: Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA

Zhang

Shen

et al. 2020

J of Cellular Biochemistry

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“…and Wang (2019) [21]. In our study, AC and CC genotypes and C alleles seem protective against HCC development.…”

Section: Original Researchsupporting

confidence: 60%

The relationship between hepatitis C - related hepatocellular carcinoma and IL-23 receptor gene polymorphism

Gad

Elnagar²,

Hussien³

et al. 2022

African Journal of Gastroenterology and Hepatology

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Aims: This study evaluated the relationship between developing interleukin-23 receptor gene polymorphism and hepatitis C-related hepatocellular carcinoma (HCC) in Egyptian patients. Patients & Methods:The current study included 250 subjects. They were divided into three groups: one hundred patients with hepatitis C virus (HCV) infection without HCC, one hundred patients with HCV and HCC, and fifty healthy non-hepatic volunteers as a control group. IL-23R gene polymorphism (rs10889677) was genotyped by restriction fragment length polymorphismpolymerase chain reaction (RFLP-PCR).Results: There was a significant difference between the studied groups regarding the frequency of genotypes and alleles (P =0.006 and < 0.001, respectively). Additionally, under the recessive inheritance model, IL-23R polymorphism is significantly associated with HCC development (P=0.001). Moreover, a significant protective effect of the rs10889677 C allele in HCC susceptibility was detected (OR = 0.15, 95% CI = 0.05-0.39, P < 0.001). AC and CC genotypes also had a significant protective effect (OR = 0.16, 95% CI = 0.05-0.46, P < 0.001). Conclusions:there is a possible relationship between IL-23R (rs10889677) polymorphism and HCC risk in Egyptian individuals where AC and CC genotypes and C alleles are protective.

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“…2 Growing evidence has also highlighted the role of genetic polymorphisms in HCC, suggesting an important role for genetic factors in carcinogenesis. 3 , 4 However, the potential value of genetic polymorphisms in HCC remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis

et al. 2020

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Background Interleukin-12 (IL-12) is considered to be a risk factor for cancer; however, its role in hepatocellular carcinoma (HCC) remains unknown. This study aimed to explore the impacts of the IL-12 rs3212227 and rs568408 gene polymorphisms on HCC. Methods We searched PubMed, Embase, Web of Science, and Chinese Knowledge Infrastructure databases for studies on the associations between HCC and IL-12 rs568408 and rs3212227 polymorphisms published prior to 1 May 2020. The effects of the polymorphisms on HCC susceptibility were presented as odds ratios (ORs) and associated 95% confidence intervals. Results Seven studies were ultimately included, including 2375 cases and 3445 controls. The rs3212227 polymorphism was significantly associated with the risk of HCC in both the dominant model (CC+AC vs. AA, OR=1.22) and the allele model (C vs. A, OR=1.12). Combined analysis of rs568408 yielded a significant relative risk for HCC in the dominant (AA+AG vs. GG, OR=1.13), recessive (AA vs. AG+GG, OR=1.72), allele (A vs. G, OR=1.29), heterozygote (AG vs. GG, OR=1.27), and homozygote models (AA vs. GG, OR 1.17). Conclusion The IL-12 rs3212227 and rs568408 gene polymorphisms are associated with an increased risk of HCC.

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Correlations of IL-23R gene polymorphism with clinicopathological characteristics and prognosis of hepatocellular carcinoma patients after interventional therapy

Cited by 5 publications

References 28 publications

Retracted: Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA

Retracted: Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA

The relationship between hepatitis C - related hepatocellular carcinoma and IL-23 receptor gene polymorphism

Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis

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