Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis

Abstract

Background Interleukin-12 (IL-12) is considered to be a risk factor for cancer; however, its role in hepatocellular carcinoma (HCC) remains unknown. This study aimed to explore the impacts of the IL-12 rs3212227 and rs568408 gene polymorphisms on HCC. Methods We searched PubMed, Embase, Web of Science, and Chinese Knowledge Infrastructure databases for studies on the associations between HCC and IL-12 rs568408 and rs3212227 polymorphisms published prior to 1 May 2020. The effects of the polymorphisms on HCC susceptibility were presented as odds ratios (ORs) and associated 95% confidence intervals. Results Seven studies were ultimately included, including 2375 cases and 3445 controls. The rs3212227 polymorphism was significantly associated with the risk of HCC in both the dominant model (CC+AC vs. AA, OR=1.22) and the allele model (C vs. A, OR=1.12). Combined analysis of rs568408 yielded a significant relative risk for HCC in the dominant (AA+AG vs. GG, OR=1.13), recessive (AA vs. AG+GG, OR=1.72), allele (A vs. G, OR=1.29), heterozygote (AG vs. GG, OR=1.27), and homozygote models (AA vs. GG, OR 1.17). Conclusion The IL-12 rs3212227 and rs568408 gene polymorphisms are associated with an increased risk of HCC.

Single Nucleotide Polymorphisms in Cytokine Genes are Associated with the Susceptibility to Oral Squamous Cell Carcinoma

“…IL-12B rs3212227 polymorphism is crucial for the development of cancer because the A > C allele can decrease cytokine levels (do Carmo Vasconcelos de Carvalho et al, 2012). Consistent with a previous meta-analysis study on hepatocellular carcinoma (Kong et al, 2020), in our study, haplotype analysis of GG+GG in IL-12A and IL-12B yielded an elevated risk for oral cancer.…”

Identification of copper metabolism-related subtypes and establishment of the prognostic model in ovarian cancer

“…In head and neck cancer, P2RY14 is also a potential biomarker for immune regulation of the tumor microenvironment and good prognosis (42). In addition, more meta-analyses have shown that potentially functional polymorphisms of IL12A and IL12B are thought to increase the risk of malignancies such as gastric, lung, and cervical cancers (43)(44)(45). TLL1 is significantly upregulated in OC patients and has been suggested as a prognostic marker in OC patients (46,47), and the same results were obtained in our study.…”