Correlations of brain MRI parameters to disability in multiple sclerosis

Schreiber, Karen; Sørensen, Per Soelberg; Koch‐Henriksen, Nils; Wagner, A.; Blinkenberg, Morten; Svarer, Claus; Petersen, Hans Christian

doi:10.1034/j.1600-0404.2001.00041.x

Cited by 38 publications

(31 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to previous studies with fewer patients, [14][15][16][17][18][19][20][21][22][23][24][25] this cross-sectional analysis of 1,312 placebo patients revealed significant although weak or at most modest relationships between MS lesion burden and age at disease onset, disease duration, disease course, EDSS, relapse rate (prior 12 months), certain presenting symptoms, and gadolinium enhancement. Not previously described is the finding of a plateauing relationship between BOD and higher EDSS values (greater than 4.5).…”

Section: Discussionsupporting

confidence: 84%

MRI T2 lesion burden in multiple sclerosis

Held²,

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 84%

MRI T2 lesion burden in multiple sclerosis

Held²,

et al. 2006

View full text Add to dashboard Cite

show abstract

“…2), which does not allow predicting the disease progression for each patient. Our results are similar to those found in other studies and the degree of significance is weak or medium [11, 16,28,29,30,31,32,33]. The highest Spearman rank correlation coefficient obtained in the work of Brex et al [33] was R = 0.61.…”

Section: Discussionsupporting

confidence: 81%

Patients’ Stratification and Correlation of Brain Magnetic Resonance Imaging Parameters with Disability Progression in Multiple Sclerosis

Vaněčková¹,

Seidl²,

Krásenský³

et al. 2009

Eur Neurol

View full text Add to dashboard Cite

Aims: The objective was to correlate the change in the lesion load (LL) and brain atrophy in patients with multiple sclerosis (MS) with progression of clinical disability, represented by the Expanded Disability Status Scale (EDSS), and to test if stratification of patients according to magnetic resonance imaging (MRI) criteria can increase the predictive ability of MRI for MS clinical development. Methods: 181 patients with clinically definite relapsing-remitting MS underwent MRI for a period of up to 5 years. Grouping of patients according to the LL value at the study entry revealed a substantial increase in the Spearman rank correlation coefficient R. Results: For the low LL cohort of patients, we found a statistically significant correlation (R up to –0.71 with p < 0.01) of a later increase in the EDSS score (years 4 and 5) with increased brain atrophy in the first 2 years. For the high LL group, we found a statistically significant correlation (R up to 0.72 with p < 0.01) of a later increase in the EDSS score (years 4 and 5) with an increase in the LL value in the first year. Conclusions: We conclude that stratification of patients according to the MRI criterion (LL) can increase the predictive ability of MRI.

show abstract

“…No significant correlation was present between these parameters and EDSS termined with MRI in patients with MS and disability has been investigated in many studies and most have reported no such correlation 16,17 . All these data suggest that disability is not dependent solely on the white matter and grey matter lesion burden shown with conventional MRI techniques.…”

Section: Discussionmentioning

confidence: 98%