Correlations between NLR, NHR, and clinicopathological characteristics, and prognosis of acute ischemic stroke

Abstract

Neuroinflammation plays an essential role in the process of acute ischemic stroke (AIS) injury repair. The current study seeks to investigate the relationship between the neutrophil/lymphocyte ratio (NLR) and neutrophil/high-density lipoprotein cholesterol ratio (NHR) and AIS disease severity and short-term prognosis. As such, the primary aim of this study is to improve AIS diagnosis and treatment. A total of 136 patients with AIS at the Nantong Third People’s Hospital were retrospectively analyzed. The inclusion criteria comprised patients with ischemic stroke admitted to the hospital <24 hours after symptom onset. Baseline, clinical, and laboratory data were collected from all patients within 24 hours of admission. Univariate, multivariate and receiver operating characteristic curve analysis were performed to determine the relationship between NLR, NHR, AIS severity, and short-term prognosis. NLR (odds ratio [OR] = 1.448, 95% confidence interval [CI] 1.116–1.878, P = .005) and NHR (OR = 1.480, 95% CI 1.158–1.892, P = .002) were identified as independent risk factors for stroke severity. Additionally, the correlation between combined NLR and NHR and AIS severity achieved a sensitivity of 81.4% and specificity of 60.4% with a best cutoff value of 6.989. This outcome was superior to that of the single composite inflammatory index. Moreover, NLR (OR = 1.252, 95% CI 1.008–1.554, P = .042) was an independent risk factor for poor short-term prognosis in patients with AIS. When the optimal cutoff value was 2.605, the sensitivity of NLR correlation with the short-term prognosis of AIS was 82.2%, and the specificity was 59.3%. NLR combined with NHR exhibits a strong correlation with disease severity in AIS. Meanwhile, an elevated NLR in patients with AIS can predict a poor short-term prognosis.

Body fluids biomarkers associated with prognosis of acute ischemic stroke: progress and prospects

“…Meanwhile, Sadeghi et al have found that a high NLR-low LMR (lymphocyte-monocyte ratio) combination as observed at 24 h after thrombolysis can serve as an independent predictor of 3-months poor outcome in AIS patients [ 21 ]. Studies have also shown that high baseline NLR is an independent risk factor for poor prognosis in early neurodegenerative AIS [ 22-24 ]. To date, NLR is a reliable prognostic marker for AIS, and its prognostic value has been fully proven.…”

Histopathological lesions induced by stroke in the encephalon

“…According to some studies, stroke registers a prevalence of over 100 million cases worldwide, with about 12.2 million new cases of strokes every year and a mortality of about 6.55 million per year [ 2 , 3 ]. In addition to the high number of deaths, stroke causes about five million cases of permanent disability annually [ 4 ]. Statistics show that stroke is currently the second leading cause of death and the third major cause of disability globally [ 2 , 5 ].…”