Correlations between anthropometry and lipid profile in women with PCOS

Kiranmayee, Donthu; Kavya, K. V.; Himabindu, Y; Sriharibabu, M; Madhuri, Gadi Leela Jaya; Venu, Swargam

doi:10.4103/jhrs.jhrs_108_16

Cited by 29 publications

(14 citation statements)

References 24 publications

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“…These disorders are observed in peripheral tissues - adipocytes and skeletal muscles, but also in the cells of the ovarian granulosa and theca cell layers and in fibroblasts [ 4 ]. Around 70% of patients with PCOS show lipid metabolism disorders manifested by quantitative and qualitative changes in the parameters of the lipid profile and lipoproteins [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Treated and Untreated Subclinical Hypothyroidism on Metabolic Profile in Women with Polycystic Ovary Syndrome

Kowalczyk

Radosz

Barański

et al. 2021

International Journal of Endocrinology

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Background. Polycystic ovary syndrome (PCOS) and hypothyroidism are the most common endocrinological disorders among women of reproductive age. Since hypothyroidism occurs more frequently in PCOS patients, it is vital to explain its clinical impact. Aim. To evaluate the impact of subclinical hypothyroidism (SCH) and its treatment on the metabolic profile of patients with PCOS. Methods. 190 women with PCOS phenotype A were enrolled in the case-control study. They were divided into three groups: 38 women with PCOS and subclinical hypothyroidism, 76 women with PCOS and SCH under thyroid replacement therapy, and 76 women with PCOS and normal thyroid function (control group). Serum lipids, fasting glucose, and insulin, as well as oral glucose tolerance tests were performed. Results. In the analyzed parameters, there were no statistic differences between the groups in relation to thyroid function. BMI turned out to be the main factor dividing the patients in terms of serum lipids, fasting glucose, fasting insulin, and oral glucose tolerance test. TSH was associated with total cholesterol and LDL cholesterol levels, whereas BMI has a dominant impact on HDL cholesterol, triglycerides, glucose, and insulin resistance. Conclusions. SCH is associated with mild lipid serum alterations in women with PCOS, but it is BMI to have a dominant impact on glucose and insulin. It seems that treatment of SCH in PCOS does not significantly alter lipid and glucose metabolism.

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Section: Introductionmentioning

confidence: 99%

The Influence of Treated and Untreated Subclinical Hypothyroidism on Metabolic Profile in Women with Polycystic Ovary Syndrome

Kowalczyk

Radosz

Barański

et al. 2021

International Journal of Endocrinology

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“…However, there was no difference between resveratrol and placebo. The lipid profile is frequently abnormal in PCOS patients [ 33 ], but the abnormalities are not consistent in all populations. According to Kiranmayee et al .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials

Fadlalmola¹,

Elhusein²,

Al-Sayaghi³

et al. 2023

Pan Afr Med J

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Polycystic ovarian syndrome (PCOS) is a metabolic and hormonal condition affecting women of a reproductive age. It causes an abnormal menstrual cycle, anovulation, infertility, acne, hirsutism, obesity, hyperlipidemia, and cardiovascular disorders. Because resveratrol decreases testosterone levels, it may be of value in treating PCOS. We aimed to evaluate the efficacy of resveratrol in treating women with PCOS. We searched for randomized clinical trials (RCTs) in PubMed, Cochrane CENTRAL, Scopus and Web of Science. With 95% confidence intervals, the data was retrieved and analyzed as a mean difference (MD) or a standardized mean difference (SMD). Four RCTs with 218 women were included in the analysis. Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo. Resveratrol is effective in treating women with PCOS due to reducing the levels of testosterone, LH, and DHEAS. In combination with other treatments, especially for hyperlipidemia, resveratrol is beneficial for women diagnosed with PCOS.

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“…This is due to influence of age, BMI, insulin resistance, hyperandrogenism, genetics and environmental factors. 9 Insulin resistance resulting in hyperinsulinemia is associated with diverse adverse effects on regulating lipid metabolism in PCOS subjects. Hyperinsulinemia appears to be a leading factor for development of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Study of lipid profile and insulin resistance in polycystic ovarian syndrome

Patil

Belwalkar²,

Nagane³

et al. 2022

IJCBR

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Polycystic ovarian syndrome (PCOS) is the most common metabolic and endocrine disorder in women of reproductive age group. It is the first leading cause of infertility in females with incidence of 5-10%.Polycystic ovarian syndrome encloses a spectrum of clinical and metabolic diseases that are associated with cutaneous excess androgen status which includes acne resistant to treatment, hirsuitism, male or female pattern baldness, ovulatory and menstrual disturbances such as irregular bleeding, amenorrhea, oligomenorrhea, polycystic ovaries, obesity and insulin resistance.To study lipid profile and insulin resistance in polycystic ovarian syndrome women.The present study included 60 diagnosed PCOS women in the age group of 16-40 years. Lipid profile (TC, TG and HDL) was done on fully automatic Meril 400 biochemistry analyzer. LDLwas calculated from TC, TG and HDL cholesterol as per Friedewald calculation. Fasting plasma glucose done in semiautoanalyser and serum insulin is measured by CLAI. Insulin resistance (IR) was calculated by using HOMA model (HOMA IR).Deranged serum lipids in the present study was mainly in the form of decreased HDL levels. Serum TC, TG and LDL levels were within normal range in most of the cases. Insulin resistance was prevalent in 75% PCOS cases in the present study.The women with PCOS should be screened for lipid profile which can be helpful in assessing the risk of cardiovascular disease.

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Correlations between anthropometry and lipid profile in women with PCOS

Cited by 29 publications

References 24 publications

The Influence of Treated and Untreated Subclinical Hypothyroidism on Metabolic Profile in Women with Polycystic Ovary Syndrome

The Influence of Treated and Untreated Subclinical Hypothyroidism on Metabolic Profile in Women with Polycystic Ovary Syndrome

Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials

Study of lipid profile and insulin resistance in polycystic ovarian syndrome

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