Correlations between age, prestrain, diameter and atherosclerosis in the male abdominal aorta

Horny, Lukas; Adámek, Tomáš; Gultova, Eva; Žitný, Rudolf; Vesely, Jan; Chlup, Hynek; Konvickova, S.

doi:10.1016/j.jmbbm.2011.07.011

Cited by 36 publications

(41 citation statements)

References 20 publications

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“…This study extends our previous observations reported in [22,23]. Therefore, only basic information necessary to avoid misunderstandings will be repeated here.…”

Section: Methodssupporting

confidence: 82%

“…Moreover, CAI yields more accurate results (the 95% prediction intervals in the power law models employed in [22] yielded ranges of 30.5-62.3 and 25.3-57.0 years for the mean prestrain in the female population and in the male population, respectively). [22,23]. This result is replicated in the CAI method (correlation coefficient R00.148/0.024 female/male).…”

Section: Comparison With Existing Methodsmentioning

confidence: 57%

“…It was shown in our previous studies that the magnitude of the longitudinal prestrain (the ratio between the in situ length and the ex situ length of the aortic segment) and the diameter of the abdominal aorta correlate significantly with chronological age [22,23]. However, these relationships have been found to be best fitted with the power law model.…”

Section: Introductionmentioning

confidence: 84%

“…Unfortunately, we are not able to measure the diameter in situ with desirable accuracy. It is also not clear whether the area ratio depends linearly on age since the prestrain, which is a dimensionless deformation measure, depends nonlinearly on age [22,23]. Finally, it should be noted that this was a somewhat simplified interpretation, since the cylindrical geometry of an artery is also prestrained in the circumferential direction (this strain is usually called "residual" and is manifested when a radial cut of an arterial ring is made as an abrupt opening to a sector [30,31]).…”

Section: Biomechanicsmentioning

confidence: 99%

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Age estimation based on a combined arteriosclerotic index

et al. 2011

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This study introduces a new quantity, the combined arteriosclerotic index (CAI), which is defined as the ratio between the diameter and the longitudinal prestrain of an artery. The longitudinal prestrain has been adopted as the ratio between the in situ length and the excised length of the abdominal aorta, and is a measure of arterial elasticity. During ageing, arteriosclerosis is manifested by the loss of pretension and by enlargement of the diameter of the artery. CAI combines these two effects. A sample of 61 female and 194 male autopsy measurements of human abdominal aortas shows that CAI correlates significantly with chronological age (R = 0.916/0.921; female/male). The sample had the following parameters: age 53 ± 19/48 ± 16 years; diameter of the abdominal aorta 12.4 ± 2.2/13.4 ± 2.1 mm; and longitudinal prestrain 1.13 ± 0.10/1.15 ± 0.10 (mean ± sample standard deviation; female/male). The resulting CAI was 11.2 ± 2.7/11.9 ± 2.6 mm. The classical linear regression model was employed for age estimation by CAI. The model gave a residual standard deviation of 7.6/6.3 years and a 95% prediction interval range of ± 15.4/12.5 years (female/male). A two-sample t-test confirmed that there are significant differences between the female and male population during ageing, reflected by CAI, unlike longitudinal prestrain. It was concluded that CAI is a suitable predictor of age at time of death and is easily obtainable in the autopsy room.

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“…This study extends our previous observations reported in [22,23]. Therefore, only basic information necessary to avoid misunderstandings will be repeated here.…”

Section: Methodssupporting

confidence: 82%

Section: Comparison With Existing Methodsmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 84%

Section: Biomechanicsmentioning

confidence: 99%

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Age estimation based on a combined arteriosclerotic index

et al. 2011

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“…For example, the axial stretch ratio in arteries decreases with aging but may increase due to vascular surgery [15,17,18,32]. The current model and results help us to better understand the buckling behavior of arteries under these pathological conditions.…”

Section: Discussionmentioning

confidence: 87%

Effect of Axial Stretch on Lumen Collapse of Arteries

Fatemifar

Han

2016

Journal of Biomechanical Engineering

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The stability of the arteries under in vivo pressure and axial tension loads is essential to normal arterial function, and lumen collapse due to buckling can hinder the blood flow. The objective of this study was to develop the lumen buckling equation for nonlinear anisotropic thick-walled arteries to determine the effect of axial tension. The theoretical equation was developed using exponential Fung strain function, and the effects of axial tension and residual stress on the critical buckling pressure were illustrated for porcine coronary arteries. The buckling behavior was also simulated using finite-element analysis. Our results demonstrated that lumen collapse of arteries could occur when the transmural pressure is negative and exceeded a critical value. This value depends upon the axial stretch ratio and material properties of the arterial wall. Axial tensions show a biphasic effect on the critical buckling pressure. The lumen aspect ratio of arteries increases nonlinearly with increasing external pressure beyond the critical value as the lumen collapses. These results enhance our understanding of artery lumen collapse behavior.

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