Correlations between 18F-FDG uptake by bone marrow and hematological parameters: measurements by PET/CT

Murata, Yuji; Kubota, Keiichi; Yukihiro, Masashi; Ito, Kimiteru; Watanabe, Hiroshige; Shibuya, Hitoshi

doi:10.1016/j.nucmedbio.2006.09.005

Cited by 86 publications

(86 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The authors gave a valid contribution to the search for a standardization of bone marrow uptake by demonstrating the higher stability of axial red bone marrow with advancing age compared with the peripheral bone marrow. These findings confirm the validity of the choice made by other groups [2,3]. However, some aspects of their findings probably need a further explanation to allow a more reproducible conclusion.…”

supporting

confidence: 86%

Studying the Metabolic Activity of Red Bone Marrow by Means of FDG-PET: The Need for a Standardization

Cicone

Scopinaro

2008

Mol Imaging Biol

View full text Add to dashboard Cite

Letter to the Editor: We read with interest the paper by Fan et al. [1], and we agree that a deeper understanding of the pathophysiology of red marrow could lead to a better knowledge of its involvement in neoplastic processes and therefore help in the clinical management and prognosis assessment. Because of its easiness, the measurement of red marrow activity by means of fluoro-D-deoxyglucose (FDG) positron emission tomography (PET) could be of help to this purpose, and the standardized uptake value (SUV) represents a widespread easily reproducible parameter for glucose uptake. The work by Fan et al. indeed describes the role of FDG-PET in the definition of changes in the metabolic activity of red marrow with aging. The authors gave a valid contribution to the search for a standardization of bone marrow uptake by demonstrating the higher stability of axial red bone marrow with advancing age compared with the peripheral bone marrow. These findings confirm the validity of the choice made by other groups [2, 3]. However, some aspects of their findings probably need a further explanation to allow a more reproducible conclusion.First of all, the method of calculating the SUV should be as homogeneous as possible; on this subject, methods used by the authors seem not to be so clearly defined.The way of drawing regions of interest (ROIs) on the considered transverse slices are not clearly specified; the use of noncomputed tomography-fused images for manual drawing of ROIs could be misleading because of the possibility of including structures other than the bone marrow. Moreover, the authors give no information on the use of anthropometric factors in SUV correction.In this study, the authors calculated SUV values on three consecutive transverse slices on the 12th thoracic and the fifth lumbar vertebra; then the maximal values were averaged.As first described by Prevost et al., we use a semiautomatic method for the calculation of bone marrow SUV [4,5]: the ROI is drawn automatically on the L3 vertebral body, considering all voxels with the maximum SUV and all the values between the maximum and a threshold of 75% (of the maximum itself). The choice of L3 is based on its relatively horizontal alignment, as compared to other vertebras, and allows a straightforward assessment of the bone marrow FDG activity of the whole vertebra in one plane.In 16 patients with colon cancer and without any bone metastasis, we calculated bone marrow SUV on T12, L3, and L5 vertebrae with our method and that of the authors. This work was done to evaluate differences among vertebras and between different methods in calculating the bone marrow SUV.Differences among vertebral SUV values were tested with the analysis of variance (ANOVA), whereas the difference between the two methods was tested with Student's t test.Results obtained with the two methods were not statistically significant, although our method results in systematically lower values of SUV.Regarding the considered vertebrae, SUV percent standard deviations (%SD) calculated with the met...

show abstract

supporting

confidence: 86%

Studying the Metabolic Activity of Red Bone Marrow by Means of FDG-PET: The Need for a Standardization

Cicone

Scopinaro

2008

Mol Imaging Biol

View full text Add to dashboard Cite

show abstract

“…FDG-PET imaging of patients with G-CSF-producing tumors has shown diffuse uptake of FDG throughout the bone marrow and markedly elevated uptake of FDG by the primary tumor (2). Moreover, the bone marrow uptake of FDG was found to correlate with peripheral WBC count, especially neutrophils, and to reflect the increased metabolic activity of bone marrow (8). Treatment with recombinant G-CSF has been reported to increase the metabolism and cellularity of bone marrow, resulting in increased bone marrow uptake of FDG (9).…”

Section: Discussionmentioning

confidence: 99%

G‑CSF producing oral carcinoma with diffuse uptake of FDG in the bone marrow: A case report

et al. 2017

View full text Add to dashboard Cite

Abstract.A 78-year-old male patient was referred to the Department of Oral Surgery, Hokuto Hospital (Obihiro, Japan) for painless swelling on the left neck and tongue. Histopathological examination of a biopsy specimen resulted in a diagnosis of squamous cell carcinoma of the tongue. Imaging examinations revealed cervical lymph node metastases on both sides, along with diffuse uptake of 18 F-fluorodeoxyglucose (FDG) in the bone marrow of the spine and pelvis. Hematologic tests revealed an increased white blood cell (WBC) count and serum concentrations of granulocyte colony stimulating factor (G-CSF). These findings suggested a G-CSF producing tumor, with fluctuations of WBC count, serum G-CSF concentration, and FDG uptake in the bone marrow, associated with tumor shrinkage and enlargement, an indicator of tumor status. IntroductionGranulocyte colony stimulating factor (G-CSF) is a cytokine mainly produced by macrophages, fibroblasts and endothelial cells in an inflammatory milieu. G-CSF stimulates neutrophil precursors, resulting in an increase in neutrophils, and recruits neutrophils from the bone marrow to peripheral blood. G-CSF is an important factor in infection prophylaxis, and recombinant G-CSF is universally used to treat neutropenia (1). G-CSF is also produced by non-hematologic malignancies with high leukocyte counts, consisting predominantly of neutrophils, in patients without infectious diseases. Most of these G-CSF producing tumors are present in the lungs (2), with tumors in the oral regions being rare. This report describes a patient with a tongue carcinoma producing G-CSF, as well as showing diffuse uptake of FDG in the bone marrow. Case reportIn July 2013, a 78-year-old man visited the Department of Oral Surgery, Hokuto Hospital (Obihiro, Japan) with a 2-week history of painless swelling on the left neck and tongue. The patient had no systemic complications and no significant family history. Some cervical lymph nodes on both sides were palpable (Fig. 1A). Intra-oral examination showed a tumor with induration about 40 mm in diameter on the left side of the tongue (Fig. 1B). Cytological examination of a swollen left lymph node showed atypical squamous cells, and pathological examination of a biopsy of the tongue tumor revealed a squamous cell carcinoma. A computed tomography (CT) scan with contrast demonstrated a large lateral oral tongue tumor of diameter 42 mm, without extension to the extrinsic muscles of the tongue; and some metastatic cervical lymph nodes that were enlarged, nonhomogeneously enhanced, and partially necrotic. Metastatic disease of left middle jugular lymph node was >30 mm in maximum diameter (Fig. 2). 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT showed abnormally high uptake by the tongue tumor (maximum standardized uptake value [SUVmax] 22.19) and by the four large metastatic nodes, with the large left middle jugular node having an SUVmax of 14.43 (Fig. 3A). Diffuse FDG uptake was also observed in the bone marrow of the spine and pelvis (Fig. 3B). These f...

show abstract

“…This can be explained by the fact that BM FDG accumulation mainly reflects the total uptake by hematopoietic and vascular tissue. Because the neutrophil cell series is predominant in healthy BM hematopoietic cells [11].…”

Section: Discussionmentioning

confidence: 99%

Diffusely Increased Splenic Fluorodeoxyglucose Uptake in Lung Cancer Patients

Aktaş¹,

Sarıkaya²,

Demir³

2017

Turk Thorac J

View full text Add to dashboard Cite

OBJECTIVES:This study aimed to investigate the association of diffuse splenic F-18 fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) with tumor maximum standardized uptake value (SUVmax), presence of distant metastases, and hematological and inflammatory parameters. MATERIAL AND METHODS:Initial FDG PET/CT of 15 lung cancer patients with diffuse splenic FDG uptake were retrospectively analyzed (Group 1). Twelve patients who recently underwent FDG PET/CT for histopathologically proven lung cancer were enrolled as the control group (Group 2). All 27 patients had hematological data, including C-reactive protein (CRP) level, within 5 days before or after PET/CT. To determine SUVmax, the region of interests included the tumor, liver, spleen, and iliac crest. The possible associations between the spleen/liver (S/L) and bone marrow/liver (BM/L) ratios and tumor SUVmax, presence of metastasis, and hematological parameters were evaluated. RESULTS:The S/L ratio and hemoglobin (Hb) levels were different between the two groups (p=0.000 and 0.05, respectively). The number of patients with anemia were significantly higher in Group 1 than in Group 2 (p=0.02). Although mean Hb levels were different between the two groups, there was no correlation between Hb levels and S/L ratios. There was no significant difference between the two groups with respect to the numbers of patients who had an accompanying infection site. Only CRP levels were correlated with S/L ratios in Group 1 among various other parameters (r=0.559, p=0.05). CONCLUSION:Our results suggested that inflammation degree correlated with increased splenic FDG uptake in lung cancer patients and was enhanced by anemia. Systemic inflammation and anemia could be important causes of diffusely increased splenic FDG accumulation on PET/CT examinations of lung cancer patients.

show abstract

Correlations between 18F-FDG uptake by bone marrow and hematological parameters: measurements by PET/CT

Cited by 86 publications

References 18 publications

Studying the Metabolic Activity of Red Bone Marrow by Means of FDG-PET: The Need for a Standardization

Studying the Metabolic Activity of Red Bone Marrow by Means of FDG-PET: The Need for a Standardization

G‑CSF producing oral carcinoma with diffuse uptake of FDG in the bone marrow: A case report

Diffusely Increased Splenic Fluorodeoxyglucose Uptake in Lung Cancer Patients

Contact Info

Product

Resources

About