Correlations among cognitive and behavioural assessments in patients with dementia due to Alzheimer's disease

Oliveira, Fabricio Ferreira de; Wajman, José Roberto; Bertolucci, Paulo Henrique Ferreira; Chen, Elizabeth; Smith, Marı́lia de Arruda Cardoso

doi:10.1016/j.clineuro.2015.05.010

Cited by 28 publications

(20 citation statements)

References 28 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, confirmation of frontal involvement in these patients might demand neuroimaging and a more comprehensive cognitive assessment to investigate every single domain related to these brain regions. Behavioral symptoms might also be correlated with gait in the same way that they are correlated with cognitive and functional decline in AD 25 , which would be an interesting idea for future studies.…”

Section: Discussionmentioning

confidence: 99%

Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer’s disease

Pereira

Oliveira

Schultz

et al. 2016

Arq. Neuro-Psiquiatr.

Self Cite

View full text Add to dashboard Cite

Currently, there are no studies reporting how much balance impairment coexists with gait apraxia in mild and moderate Alzheimer’s disease (AD). Objectives To assess correlations among gait apraxia, balance impairment and cognitive performance in mild (AD1, n = 30) and moderate (AD2, n = 30) AD. Method The following evaluations were undertaken: gait apraxia (Assessment Walking Skills); balance performance (Berg Balance Scale); Clinical Dementia Rating and Mini-mental State Examination (MMSE). Results While disregarding AD subgroups, Berg Balance Scale and the MMSE correlated significantly with Assessment Walking Skills and 23% of all subjects scored below its cut-off. After stratification, Berg Balance Scale correlated significantly with Assessment Walking Skills in both AD subgroups, and with the MMSE only in AD1. Conclusions Balance impairment does not necessarily coexist with gait apraxia. Gait apraxia is more prevalent in moderate AD when compared with mild AD.

show abstract

Section: Discussionmentioning

confidence: 99%

Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer’s disease

Pereira

Oliveira

Schultz

et al. 2016

Arq. Neuro-Psiquiatr.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Anxiety is usually inversely correlated with apathy, 25 whereas overall neuropsychiatric symptoms tend to correlate better with functional independence than with cognitive decline. 25,26 Antipsychotic therapy was associated with higher Neuropsychiatric Inventory total scores for mildly impaired patients, particularly regarding disinhibition, and with more delusions and more agitation for moderately impaired patients, probably representing the need for psychotropic treatment when more behavioral symptoms are present, while agitation does not usually improve with atypical antipsychotics in the long term. 26 Likewise, antidepressant therapy was associated with higher Neuropsychiatric Inventory total scores for mildly impaired and severely impaired patients (particularly regarding dysphoria), and with more agitation for moderately impaired patients, also representing the expected need for such therapy according to symptoms of depression.…”

Section: Discussionmentioning

confidence: 99%

“…1 Furthermore, moderately impaired APOE-e4 carriers had less apathy, whereas severely impaired APOE-e4 carriers had more delusions and more aberrant motor behavior. Whereas some cross-sectional studies have not found associations of APOE haplotypes with specific neuropsychiatric symptoms 25 or sleep satisfaction, 24 other studies have shown dose-dependent associations of copies of APOE-e4 with delusions, 28 aberrant motor behavior, 6 anxiety, 29 and agitation. 30 Mechanisms involve atrophy of the prefrontal cortex, 29 temporal lobe hypoperfusion, 28 cholinergic imbalance, 6 and tau-mediated disruption of frontal serotonergic and dopaminergic networks.…”

Section: 019mentioning

confidence: 99%

“…Nevertheless, more years of education were associated with less dysphoria in moderately impaired patients and with lower Neuropsychiatric Inventory total scores in severely impaired patients, particularly regarding agitation and irritability. Though an earlier study showed that educational attainment and AD duration did not affect behavior, 25 patients were not stratified by dementia stage, and some associations may have been missed. Education enhances cognitive reserve and may affect the way the brain copes with the burden of AD neuropathology, thus modulating behavior.…”

Section: 019mentioning

confidence: 99%

See 2 more Smart Citations

Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia

Oliveira

Chen

Smith

et al. 2017

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer's disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. Results: Considering 201 patients, only APOE-e4 carriers had earlier dementia onset in multiple correlations, as well as less apathy, more delusions, and more aberrant motor behavior. Both ACE polymorphisms were associated with less intense frontally mediated behaviors. Regarding LDLR variants, carriers of the A allele of rs11669576 had less anxiety and more aberrant motor behavior, whereas carriers of the A allele of rs5930 had less delusions, less anxiety, more apathy, and more irritability. CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. Conclusion: Though only APOE haplotypes affected AD onset, cerebrovascular metabolism genotypes were associated with differences in several neuropsychiatric manifestations of AD.

show abstract

Family Issues in Behavioral and Psychological Symptoms of Dementia: Unraveling Circular Pathways?

Gonçalves‐Pereira

Marques

Grácio

2016

Neuropsychiatric Symptoms of Cognitive Impairment and Dementia

View full text Add to dashboard Cite

Correlations among cognitive and behavioural assessments in patients with dementia due to Alzheimer's disease

Cited by 28 publications

References 28 publications

Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer’s disease

Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer’s disease

Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia

Family Issues in Behavioral and Psychological Symptoms of Dementia: Unraveling Circular Pathways?

Contact Info

Product

Resources

About