Correlational Study of Diabetic Retinopathy and Hearing Loss

Ooley, Caroline; Le, Kim; Kim, Allen; Rock, Nathan; Cardenal, Molly; Kline, Rebecca; Aldrich, D.; Hayes, John

doi:10.1097/opx.0000000000001025

Cited by 17 publications

(27 citation statements)

References 16 publications

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“…The analysis showed that the condition was significantly associated with age, male gender, consanguinity, family history of DM, and elevated blood pressure. More recently from a study by Ooley et al [ 9 ] after controlling for glucose control, as measured by HbA1c and renal function measured with serum creatinine, the presence of diabetic retinopathy was significantly associated with the severity of hearing loss in both ears (right ear, P = .018 and left ear, P = .007). Usually, the chronic hyperglycemia in diabetic patients could affect hearing leading to hearing impairment.…”

Section: Discussionmentioning

confidence: 98%

“…The results of the present study have revealed high prevalence of hearing impairment in association with retinopathy in T2DM patients. The association between diabetes and eye disease is well recognized with diabetic retinopathy as the most common eye disease in subjects with T2DM [ 9 ]. However, the link between diabetes and hearing loss has not been universally accepted until recently.…”

Section: Discussionmentioning

confidence: 99%

“…The first positive correlation was found in 1961 by Jorgensen and Bush [ 20 ] which showed that subjects with proliferative diabetic retinopathy were twice as likely to have hearing loss. However, more recent studies agree that diabetes is correlated with high-frequency hearing loss [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have attempted to identify the cause of hearing loss in T2DM [ 6 – 11 , 13 ] and found hyperglycemia to be an important risk factor. Because hyperglycemia is the principal risk factor for diabetic microvascular complications, i.e., retinopathy, neuropathy, and nephropathy [ 5 – 7 , 14 ], we hypothesize that a strong correlation between hearing loss and diabetic retinopathy will be present in T2DM patients [ 3 , 6 , 8 , 9 , 16 ]. Because low level of vitamin D was also related to increased risk of hearing loss and retinopathy, we also hypothesized that T2DM subjects who manifest hearing impairment and retinopathy may also have low plasma vitamin D levels [ 5 – 7 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Vitamin D Deficiency on Retinopathy and Hearing Loss among Type 2 Diabetic Patients

Bener

Eliacik

Cincik

et al. 2018

BioMed Research International

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Aim The current study was aiming to investigate the relation between vitamin D, retinopathy, and hearing loss among type 2 diabetes mellitus (T2DM) patients. Methods Cross-sectional study carried on 638 subjects aged between 20 and 60 years who visited the Endocrinology, Ophthalmology, and ENT Outpatient Clinics of the Medipol Hospital during the period from March 2016 to May 2017. Two audiometers Grason Stadler GSI 61 and Interacoustics AC40 Clinical audiometer were used to evaluate the hearing loss. Risk factors for diabetic retinopathy were evaluated, including age, sex, diabetes duration, glycated hemoglobin (HbA1c), hypertension, and lipid profiles. Results The mean age (± SD, in years) for retinopathy with hearing loss versus normal subjects was 47.7 ±10.2 versus 48.5±9.1. The associated risk factors were significantly higher in T2DM with hearing loss, hypertension (32.6% versus 15.7%), tinnitus (40.0% versus 18.0%), vertigo (59.7% versus 26.8%), and headache (54.9% versus 45.3%), than in normal hearing diabetes. There were statistically significant differences between hearing impairment versus normal hearing for vitamin D [19.40±9.71 ng/ml versus 22.67±9.28 ng/ml; p<0.001], calcium, magnesium, phosphorous, cholesterol, HDL-C, LDL-C, albumin, systolic blood pressure [131.70±9.25 Hg versus 127.73±11.98 Hg], diastolic blood pressure [82.20±8.60 mm Hg versus 79.80±8.20 mm Hg], and microalbuminuria. Multivariate logistic regression analysis revealed that variables such as vertigo, duration of DM, mobile/I pad phone, vitamin D deficiency, sleeping disturbance, headache, frequently TV watching, tinnitus, cigarette smokers, and hypertension were considered at higher risk as a predictors of retinopathy with hearing loss among diabetic patients. Conclusion Vitamin D deficiency is considered as a risk factor for diabetic retinopathy and hearing loss among diabetic patients. Meanwhile, hyperglycemia could be considered as a modifiable risk factor for diabetic retinopathy; tight glycemic control may be the most effective and important therapy for improving quality of life and substantially reducing the incidence of retinopathy and in T2DM patients.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Vitamin D Deficiency on Retinopathy and Hearing Loss among Type 2 Diabetic Patients

Bener

Eliacik

Cincik

et al. 2018

BioMed Research International

View full text Add to dashboard Cite

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“…Data have shown that the incidence of diabetic cataracts in both types of diabetes is close to 15%. Given the increase in diabetes prevalence and the duration of the disease, this figure is likely to rise ( 9 ). The progression of diabetic cataracts is fast and poses a serious threat for blindness among advanced diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of calcium dobesilate on Nrf2, Keap1 and HO-1 in the lenses of D-galactose-induced cataracts in rats

et al. 2017

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Abstract. This study investigated the effects of calcium dobesilate on Nrf2, Keap1 and HO-1 in the lenses of D-galactose-induced cataracts in rats. Thirty Sprague-Dawley rats were randomly divided into three groups: a blank control group, a model control group and a model administration group. A normal diet was given to the rats in the blank control group and the rats with D-galactose-induced cataracts of the model control group. Calcium dobesilate was also given to the rats with D-galactose-induced cataracts of the model administration group. A slit lamp microscope was used to check the degree of lens opacity. RT-PCR and western blot analysis were used to detect the mRNA and protein expression of Nrf2, Keap1 and HO-1 in the lenses of the three groups. There was a significant difference in the degree of lens opacity among the three groups (P<0.05). The model control group was the most turbid of the three groups, followed by the model administration group. Moreover, the mRNA and protein expression of Nrf2, Keap1 and HO-1 in the lenses of the three groups were also significantly different (P<0.05). The mRNA levels of Nrf2 and HO-1 were the highest in the model control group, followed by the model administration group, and were the lowest in the blank control group. However, the mRNA expression level of Keap1 among the three groups had an opposite trend. In conclusion, calcium dobesilate can effectively increase the levels of Nrf2 and HO-1 in the lenses of diabetic cataract rats and inhibit the level of Keap1. Therefore, the therapeutic effect of calcium dobesilate against cataracts is related to the improvement of the Nrf2-Keap1 signaling pathway.

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Association Between Microvascular Retinal Signs and Age-Related Hearing Loss in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)

Kim

Reed

Betz

et al. 2020

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Given that age-related hearing loss is highly prevalent and treatable, understanding its causes may have implications for disease prevention.OBJECTIVE To investigate whether microvascular retinal signs are associated with age-related hearing loss attributable to a hypothesized underlying shared pathologic entity involving microvascular disease. DESIGN, SETTING, AND PARTICIPANTSThe Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) is a community-based prospective cohort study of 15 792 men and women aged 45 to 64 years at baseline. The ARIC-NCS participants returned for a fifth clinic visit in 2011-2013 and a sixth clinic visit in 2016-2017. Participants were recruited from 4 US communities (Washington County, Maryland; Forsyth County, North Carolina; Jackson, Mississippi; and Minneapolis suburbs, Minnesota). Participants included a subset of the ARIC-NCS cohort with complete covariate data who underwent retinal fundus photography at visit 5 (2011)(2012)(2013) and completed hearing assessment at visit 6 (2016-2017) (N = 1458). Overall, 453 participants had diabetes; of those, 68 had retinopathy. Of 1005 participants without diabetes, 42 had retinopathy.EXPOSURES Microvascular retinal signs included retinopathy, arteriovenous (AV) nicking, and generalized arteriolar narrowing measured using the central retinal arteriolar equivalent (CRAE). MAIN OUTCOMES AND MEASURESHearing was measured using the better-hearing ear pure-tone average (PTA) of air conduction speech thresholds (0.5, 1, 2, and 4 kHz). Multivariable-adjusted linear and ordered logistic regression was used to estimate the association between microvascular retinal signs and age-related hearing loss to describe the precision of the estimates and provide a plausible range for the true association. RESULTS After full adjustment among 1458 individuals in the analytic cohort (mean [SD] age, 76.1 [5.0] years [age range, 67-90 years]; 825 women [56.6%]; 285 black [19.5%]), the difference in PTA per dB hearing level in persons with and without retinopathy was 2.21 (95% CI, −0.22 to 4.63), suggesting that retinopathy is associated with poorer hearing, although the width of the 95% CI prevents definitive conclusions about the strength of the observed association. Restricting the analysis to participants without diabetes, the difference in PTA associated with retinopathy was even greater (4.14; 95% CI, 0.10-8.17 dB hearing level), but the large width of the 95% CI prevents definitive conclusions about the association. In analyses quantifying the mean differences in hearing thresholds at individual frequencies by retinopathy status, the estimates trended toward retinopathy being associated, contrary to expectation, with better high-frequency hearing. At 8 kHz, the estimated difference in hearing thresholds in persons with retinopathy vs those without was −4.24 (95% CI, −7.39 to −1.09). CONCLUSIONS AND RELEVANCEIn this population-based study, an association between the presence of microvascular retinal signs and hearing loss was observed, ...

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Correlational Study of Diabetic Retinopathy and Hearing Loss

Cited by 17 publications

References 16 publications

The Impact of Vitamin D Deficiency on Retinopathy and Hearing Loss among Type 2 Diabetic Patients

The Impact of Vitamin D Deficiency on Retinopathy and Hearing Loss among Type 2 Diabetic Patients

Effects of calcium dobesilate on Nrf2, Keap1 and HO-1 in the lenses of D-galactose-induced cataracts in rats

Association Between Microvascular Retinal Signs and Age-Related Hearing Loss in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)

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