Correlation Study of ( CMV ) in the Presence of ( HCV ) and / or ( HBV ) in Hepatocellular Carcinoma ( HCC ) Patients

Talaat, Randa M.; El-Bassuoni, Maha A.; Fathey, Omar; Elrefaai, Mohamed M.

doi:10.12816/0024874

Cited by 1 publication

(2 citation statements)

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“…HCMV infection was appeared to be a dangerous issue in patients with malegnancies (Wang et al, 2011). The association of HCMV infection with HCC is not completely defined till now (EL-Bassuoni et al, 2014). The diagnosis of HCMV active infection was depended on the detection of HCMV replication in the blood (HCMV-DNA) that referred to as HCMV viremia and virus reactivation in absence of effective immunity leading to serious disease (Gandehi and Khanna, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the direct carcinogenic effects of HCV may be achieved by the mechanisms involving viral proteins interference with host cell metabolism (Koike, 2005). Human cytomegalovirus (HCMV) is a beta -herpes virus that may affect 60-80% of the human population worldwide (Offermanns and Rosenthal, 2008;Bader El Din et al, 2010), and approxi-mately 100 % seroprevalence in Africa (EL-Bassuoni et al, 2014). HCMV genomic DNA is a linear, double-stranded molecule, surrounded by a protein lining, called matrix, which contains highly immunogenic phosphoproteins that can interfere with cellular cycle of the host cell.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of Human Cytomegalovirus Viremia among Egyptian Hepatitis C - Patients with Hepatocellular Carcinoma

Khedr

Ibrahim

Barakat

et al. 2016

Egyptian Academic Journal of Biological Sciences, G. Microbiolo

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Background: Hepatocellular carcinoma (HCC) is the major hepatic complication that may arise after many years of hepatitis C virus (HCV) infection. In Egypt, HCV represents the major health problem, also human cytomegalovirus (HCMV) is known as one of the highest un-resolved latent infections among general population. HCMV viremia in the co-infection with HCV may cause life threatening in HCC patients. Our study aimed to detect HCMV viremia in HCV-patients experienced HCC, and to investigate its role in disease worsening. Methods: In HCC patients, HCV-RNA viral load was determined by real-time polymerase chain reaction. In HCV-HCC patients, HCMV-DNA was detected by amplification of gB gene region using nestedpolymerase chain reaction. Results: HCMV-DNA was detected in 4/73 in control subjects with prevalence rate of 5.4%, whereas HCMV-DNA was recorded in 24/75 HCV-HCC patients with prevalence rate of 32 %. Data on the level of alpha feto protein (AFP) was available for 59 out of 75 HCV-HCC patients, this enabled us to differentiate between low risk HCC group of 40/59 patients with AFP < 500 ng/ml, from them HCMV-DNA was detected in 14/40 patients with prevalence rate 35%, and high risk HCC group of 19/59 patients with AFP > 500 ng /ml, from them HCMV-DNA was reported in 9/19 patients with prevalence rate 47.37%. High significant prevalence rate of HCMV-DNA (P < 0.001) among control and HCC subjects was reported. Significant change in HCMV-DNA prevalence between low and high risk HCC groups could not be achieved but tendency of higher prevalence rate in HCMV-DNA was observed towards HCC high risk group of patients. Conclusion: we illustrated information about HCMV/ HCV co-infection in HCC patients, which referred to the association of HCMV viremia with HCV-HCC patients, as well as the tendency of elevation in HCMV viremia from low to high risk HCC patients depending on AFP threshold of 500 ng/ml.

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Section: Discussionmentioning

confidence: 99%