Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population

Ning, Sisi; Yao, Mei; Wu, Yuan; Zhou, Xiao Qin; Zhong, Changtao; Yan, Kui; Wei, Zhengbo; Xie, Ying

doi:10.2147/cmar.s167114

Cited by 2 publications

(3 citation statements)

References 20 publications

(28 reference statements)

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“…44 The 9-repeat variants in the neck region of DC-SIGNR may influence the risk of NPC in the Chinese population. 45 However, the question of which receptor on EBV binds to DC-SIGN has yet to be answered.…”

Section: F I G U R E 1 Mechanism Of Ebv Infection In B Cells and Epit...mentioning

confidence: 99%

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The immune escape mechanism of nasopharyngeal carcinoma

et al. 2023

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Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the nasopharyngeal mucosa. Its incidence rate ranks first among otorhinolaryngological malignancies, with apparent familial aggregation, regional concentration, and ethnic susceptibility. 1 The International Agency for Research on Cancer reported 133 354 cases of NPC in 2020, only 0.7% of all cancer diagnoses that year. However, more than 70% of the new cases occurred in North Africa, Southeast Asia, and southern China, with significant geographical differentiation. 2 Moreover, the age-standardized incidence rate in these areas is 4-25 cases per 100 000 individuals, which is 50-100 times higher than in the rest of the world. [2][3][4] From the perspective of demographics, the peak age of NPC onset is 50-60 years old, and the probability of men suffering from the disease is 2-3 times that of women. 1,2 The disease's unique epidemiological features have prompted research into its risk factors, including EBV infection, host genetics, and environmental risk factors. According to the World Health Organization, NPC is divided into nonkeratinizing carcinoma and keratinizing squamous cell carcinoma, and the former is further divided into

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Section: F I G U R E 1 Mechanism Of Ebv Infection In B Cells and Epit...mentioning

confidence: 99%

“…DC‐SIGN SNPs (rs4804803, rs7252229, and rs735240) have also been reported to be associated with susceptibility to NPC 44 . The 9‐repeat variants in the neck region of DC‐SIGNR may influence the risk of NPC in the Chinese population 45 . However, the question of which receptor on EBV binds to DC‐SIGN has yet to be answered.…”

Section: Ebv and Npcmentioning

confidence: 99%

The immune escape mechanism of nasopharyngeal carcinoma

et al. 2023

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“…The environmental factors such as dietary pattern and geographic areas may explain the contrasting role of this SNP in NPC susceptibility. Moreover, through genetic analysis, the dendritic cells specific intercellular adhesion molecule 3-grabbing nonintegrin ( DC-SIGN ) gene variants with SNPs rs7252229, rs735240, and rs4804803 were also found to be associated with NPC susceptibility [ 24 , 25 ]. Polymorphism in DC-SIGN with genotype GG at rs735240 and AA at rs2287886 enable dendritic cells to be easily infected by cytomegaloviruses, which have similar a structure to EBV.…”

Section: Npc Diagnostic Biomarkersmentioning

confidence: 99%

Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma

Siak

Khoo

Leong

et al. 2021

Cancers

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Nasopharyngeal carcinoma (NPC) is an epithelial malignancy that shows a remarkable ethnic and geographical distribution. It is one of the major public health problems in some countries, especially Southern China and Southeast Asia, but rare in most Western countries. Multifactorial interactions such as Epstein–Barr virus infection, individual’s genetic susceptibility, as well as environmental and dietary factors may facilitate the pathogenesis of this malignancy. Late presentation and the complex nature of the disease have led it to become a major cause of mortality. Therefore, an effective, sensitive, and specific molecular biomarker is urgently needed for early disease diagnosis, prognosis, and prediction of metastasis and recurrence after treatment. In this review, we discuss the recent research status of potential biomarker discovery and the problems that need to be explored further for better NPC management. By studying the aberrant pattern of these candidate biomarkers that promote NPC development and progression, we are able to understand the complexity of this malignancy better, hence positing our stands better towards strategies that may provide a way forward to the discovery of more reliable and specific biomarkers for diagnosis and targeted therapeutic development.

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Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population

Cited by 2 publications

References 20 publications

The immune escape mechanism of nasopharyngeal carcinoma

The immune escape mechanism of nasopharyngeal carcinoma

Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma

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