Correlation of total serum immunoglobulin E level, sputum, and peripheral eosinophil count in assessing the clinical severity in bronchial asthma

Kumar, Ravindra; Ranganadin, Pajanivel; Koteeswaran, G; Menon, Surendra K.; Charles, Pravin

doi:10.4103/lungindia.lungindia_73_16

Cited by 22 publications

(10 citation statements)

References 36 publications

(38 reference statements)

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“…Although their scientific validity against positive allergens is well established, the predictive value of plain blood IgE levels is debatable. The results of this study (Kumar et al, 2017) also showed that there is a link between a person's clear serum IgE levels and their clear serum IgE levels.…”

Section: Introductionsupporting

confidence: 64%

Relationship between Serum IgE and Airway Responsiveness in Adults with Asthma

Almehmadi

Alghamdi²,

Kelantan³

et al. 2022

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Several cell types and a wide variety of inflammatory mediators are involved in the chronic airway inflammation that characterizes asthma. The study aims to uncover a link between high serum immunoglobulin E IgE levels and childhood asthma. This cross-sectional study was conducted from March to July 2022 at Khyber Teaching Hospital Peshawar, Pakistan. Asthma patients traveling to the clinic's out-of-the-way chest medication branch were given a clear explanation of the review's goal, its system, and its security measures. This study included 65 patients. This study lists demographic, clinical, and useful characteristics. The research review included 18-60-year-old patients. 40 (66.67%) of our 60 patients were men, and 20 (33.33%) were women. Out of 60 cases, 56.67% had severe asthma. The researchers concluded that the serum levels of immunoglobulin E in asthmatics were much higher than those in normal patients. The severity of the patient's asthma was correlated with an increase in their IgE levels, on average.

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Section: Introductionsupporting

confidence: 64%

Relationship between Serum IgE and Airway Responsiveness in Adults with Asthma

Almehmadi

Alghamdi²,

Kelantan³

et al. 2022

Egyptian Academic Journal of Biological Sciences. C, Physiology

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“…In addition, elevated blood eosinophils and serum IgE were associated with severe persistent asthma. 33 Evidence suggests that a positive BDR is associated with low lung function and elevated T2 biomarkers in asthma. 34,35 Overall, the current findings consistently supported the concept that the positive BDR is a reliable physiologic indicator that is associated with severe airflow obstruction and airway inflammation.…”

Section: Discussionmentioning

confidence: 99%

Potentiality of impulse oscillometry to evaluate bronchodilator reversibility in untreated adult patients with newly diagnosed asthma

Hsiao

Lin

Jeng

et al. 2022

Journal of the Chinese Medical Association

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Background: Identifying positive bronchodilator reversibility (BDR) helps the diagnosis of asthma. However, not all patients can adequately perform the forced expiration during the spirometry test. An alternative test is required. Impulse oscillometry (IOS) is an effort-independent technique that enables the measurement of lung mechanics during quiet tidal breathing. We investigated the potentiality of IOS to evaluate BDR in untreated adult patients with newly diagnosed asthma (UAPNDS). Methods: All UAPNDS (aged 20–80 years) who never smoke and underwent IOS and spirometry before and after salbutamol inhalation at their initial visit to the hospital from March 22, 2017, to December 31, 2019, were identified. A total of 323 patients were enrolled. Data from the medical record, including demographic characteristics, laboratory examination, spirometric data, and IOS parameters, were retrospectively reviewed. The associations of parameters with the positive BDR and the performance of parameters in predicting the positive BDR were evaluated by statistical methods. Results: Patients (n = 323) had a median age of 64 years and were mostly female (67.5%). Several variables, including serum total immunoglobulin level, blood eosinophil counts, blood eosinophil percentage (%), and two IOS parameters, were found to be different between the positive (n = 93) and negative BDR (n = 230) groups. Multivariate logistic regression analyses after adjustment by cofactors revealed that the percentage change of the area under the reactance curve between 5 Hz and resonant frequency [ΔAx (%)] after salbutamol inhalation was the only independent factor for the positive BDR. The area under the receiver operating characteristic curve of ΔAx (%) in predicting the positive BDR was 0.614 (p = 0.0013), and its optimal cutoff value was −53.8% (sensitivity, 39.78% and specificity, 80.43%). Conclusion: In addition to spirometry, ΔAx (%), an IOS parameter, may serve as a novel indicator to evaluate BDR in UAPNDS.

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“…In a cross-sectional study, blood eosinophils, sputum eosinophils and elevated levels of total IgE (>100 IU/mL) were significantly correlated with severe persistent asthma [ 85 ]. In a systematic review and meta-analysis, Korevaar et al found only moderate accuracy regarding the use of blood eosinophils, IgE and FeNO in predicting airway eosinophilia.…”

Section: Biomarkersmentioning

confidence: 99%

Allergic Asthma in the Era of Personalized Medicine

Papapostolou

Makris

2022

JPM

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Allergic asthma is the most common asthma phenotype and is characterized by IgE sensitization to airborne allergens and subsequent typical asthmatic symptoms after exposure. A form of type 2 (T2) airway inflammation underlies allergic asthma. It usually arises in childhood and is accompanied by multimorbidity presenting with the occurrence of other atopic diseases, such as atopic dermatitis and allergic rhinitis. Diagnosis of the allergic endotype is based on in vivo (skin prick tests) and/or in vitro (allergen-specific IgE levels, component-resolved diagnosis (CRD)) documentation of allergic sensitization. Biomarkers identifying patients with allergic asthma include total immunoglobulin E (IgE) levels, fractional exhaled nitric oxide (FeNO) and serum eosinophil counts. The treatment of allergic asthma is a complex procedure and requires a patient-tailored approach. Besides environmental control involving allergen avoidance measurements and cornerstone pharmacological interventions based on inhaled drugs, allergen-specific immunotherapy (AIT) and biologics are now at the forefront when it comes to personalized management of asthma. The current review aims to shed light on the distinct phenotype of allergic asthma, ranging over its current definition, clinical characteristics, pathophysiology and biomarkers, as well as its treatment options in the era of precision medicine.

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Correlation of total serum immunoglobulin E level, sputum, and peripheral eosinophil count in assessing the clinical severity in bronchial asthma

Cited by 22 publications

References 36 publications

Relationship between Serum IgE and Airway Responsiveness in Adults with Asthma

Relationship between Serum IgE and Airway Responsiveness in Adults with Asthma

Potentiality of impulse oscillometry to evaluate bronchodilator reversibility in untreated adult patients with newly diagnosed asthma

Allergic Asthma in the Era of Personalized Medicine

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