Correlation of the Lipid Profile, BMI and Bone Mineral Density in Postmenopausal Women

Bijelic, Radojka; Balaban, Jagoda; Miličević, Snježana

doi:10.5455/msm.2016.28.412-415

Cited by 34 publications

(37 citation statements)

References 16 publications

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“…Osteoporosis involves a number of factors which can be divided into variable and constant factors i.e. genetic factors and factors from the environment (4). They can individually or in synergy significantly contribute to the loss of bone mass leading to osteoporosis (5-7).…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Osteoporosis in Postmenopausal Women

2017

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Introduction:Scientific studies show that many factors related to lifestyles affect the reduction of bone mineral density and osteoporosis in postmenopausal women.Goal:The goal of this study was to determine whether smoking, drinking coffee and alcohol in menopausal women contribute to the reduction of bone mass and osteoporosis, as well as the impact of physical activity on bone mass.Material and methods:The study was carried out as case study and matched controls. The group of cases consisted of 100 females in postmenopausal age, in which by the DEXA method was newly diagnosed osteoporosis at the Clinic of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center of RS during 2015-2016, while the control group consisted of 100 females in a postmenopausal age without diagnosed osteoporosis. The groups were matched by age (±2 years). In order to collect demographic data and information on risk factors for osteoporosis and lifestyle of patients was used the questionnaire Bone Mineral Density Questionnaire- Female of the Irish Association for osteoporosis.Results:Testing the significance of differences in terms of smoking showed that the studied groups are statistically significantly different in terms of smoking (χ2=24.025, p=0.000). In terms of consumption of coffee, a statistically significant difference was found between the group of cases and control group (χ2=0.615, p=0.735). When observing the obtained information about the consumption of alcohol, we find that this preventable risk factor in the present study did not show as significant for osteoporosis in postmenopausal women (χ2=4.35, p=0.114). Statistical analysis shows that there are significant differences between the group of cases and control group in terms of physical activity (χ2=7.30, p=0.026). Analysis of the data of our study by univariate logistic regressions showed that smoking (p=0.000) was statistically significantly associated with osteoporosis, while physical activity is a protective factor for bone mass (p=0.036). Results of multivariate logistic regression showed that the independent risk factors for osteoporosis in postmenopausal women is smoking (OR=1.665; p=0.006).Conclusion:The results of our study show that smoking is an independent risk factor for osteoporosis in postmenopausal women, and physical activity is a protective factor for bone mass retention. Through education and certain preventive measures should be stressed the importance of these factors on bone health from the earliest period.

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Section: Introductionmentioning

confidence: 99%

Risk Factors for Osteoporosis in Postmenopausal Women

2017

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“…Many observational studies have investigated the association between serum cholesterol [total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C)] level and BMD. However, the results are controversial ( 8 , 9 , 17 – 26 ). In a Northern Sydney Twin Study, Makovey et al found an inverse relationship between serum TC and LDL levels and lumbar spine and whole body BMD in postmenopausal women as well as between HDL levels and BMD at all sites in premenopausal women ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Cholesterol Level and Osteoporotic Fractures

et al. 2018

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ObjectivePrevious epidemiological studies have found an association between serum cholesterol level and bone mineral density. However, epidemiological studies evaluating the association between serum cholesterol level and the incidence of osteoporotic fracture are scant. Therefore, the objective of this study was to investigate whether serum cholesterol levels in Chinese participants aged 55 years or older was associated with an increased risk of osteoporotic fracture.Materials and methodsWe performed a cross-sectional study, including 1,791 participants (62.1% postmenopausal women and 213 fractures). Standardized self-administered questionnaires, physical examination, laboratory tests, and dual-energy X-ray absorptiometry examination were performed. Multivariate-adjusted logistic regression models were used to evaluate associations between serum cholesterol [total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C)] levels and the osteoporotic fracture risk.ResultsAfter adjusting for potential confounding factors, there were no associations between per SD increase in TC and LDL level and an increased risk of osteoporotic fracture in total participants, and in men and women as individual groups. There was a significant association between per SD increase in HDL-C level and an increased risk of osteoporotic fracture in total participants [odds ratios (OR) 1.20, 95% confidence interval (CI) 1.03, 1.40, P = 0.023] and in women (OR 1.37, 95% CI 1.12, 1.68, P = 0.003), whereas no association was observed in men (OR 1.01, 95% CI 0.73, 1.40, P = 0.951). Additionally, we found a significant association between per SD increase in TG level and an increased risk of osteoporotic fracture in total participants (OR 1.20, 95% CI 1.04, 1.38, P = 0.015). In women, a nonlinear relationship was observed between per SD increase in TG level and an increased risk of osteoporotic fracture. The risk of osteoporotic fracture in women increased with TG level >1.64 mmol/L (OR 1.93, 95% CI 1.24, 3.00, P = 0.004).ConclusionAmong Chinese older adults, serum HDL-C level is significantly associated with a risk of osteoporotic fractures in women, and serum TG level is significantly associated with a risk of osteoporotic fractures in total participants and in women with TG >1.64 mmol/L.

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“…Some studies suggest that dyslipidemia could result in both increased bone resorption and decreased bone formation [1]. Various studies have tried to evaluate the association between lipid level and osteoporosis, but the results were proved to be controversial [1][2][3][4][5][6][7]. Some studies found an inverse relationship with bone mineral density (BMD) [1][2][3][4][5], whereas others have shown a positive correlation [6] or no correlation [7].…”

Section: Introductionmentioning

confidence: 99%

Lipid Levels Related to Osteoporosis in Patients with Type 2 Diabetes

Xuenong

et al. 2018

Exp Clin Endocrinol Diabetes

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Objective Osteoporosis is a systemic skeletal disorder characterizedby reduced bone mass, deteriorated bone structure. Various studies have tried to evaluate the association between lipid level and osteoporosis, but the results were proved to be controversial. The objectives of this study are to assess the correlation between BMD and serum lipid levels, to determine independent variables associated with osteoporosis and osteopenia in men and postmenopausal women with type 2 diabetes (T2D). Materials and methods All participants of the study were carried out biochemical analysis of blood and the analysis of the lipid profile that included total cholesterol (TC) and triglyceride (TG). Physical examination and dual-energy X-ray absorptiometry examination were performed. Multiple linear regression and multivariate logistic regression were used to evaluate associations between serum TC and TG levels and the osteoporosis or osteopenia. Results The level of serum TG was directly correlated with BMD at the lumbar spine in all patients in multiple linear regression models. After adjusting for potential confounding factors, decreased level of serum TG was independent risk factor for osteoporosis(p=0.022) in T2D patients. It also showed that a greater BMI was protective factor for osteoporosis (p=0.019) and lower level of β-CTX was an independent risk factor for osteopenia (p=0.008) and osteoporosis (p=0.001) in T2D patients. Conclusion Among Chinese patients with type 2 diabetes, the decreased level of serum TG might indicate a risk of osteoporosis. Further research is needed to confirm the finding and to clarify the contradictions identified.

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Correlation of the Lipid Profile, BMI and Bone Mineral Density in Postmenopausal Women

Cited by 34 publications

References 16 publications

Risk Factors for Osteoporosis in Postmenopausal Women

Risk Factors for Osteoporosis in Postmenopausal Women

Association between Serum Cholesterol Level and Osteoporotic Fractures

Lipid Levels Related to Osteoporosis in Patients with Type 2 Diabetes

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