Correlation of the Glomerular Filtration Rate Measured With the Use of DTPA-Tc99m in Live Kidney Donors With Equations Based on Creatinine and Cystatin C

García-Covarrubias, Luis; Barragán, Jorge; Castro, I.; Hernández, Karen; Reding, Arturo; Hinojosa, H.; Prieto, Patricia; García, Ángel Sánchez; Carolina, Andréa; Ortuño, D.; Carmona, Marco Antonio Torres; Fernandez, Danny; Diliz, H

doi:10.1016/j.transproceed.2017.12.039

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…The currently observed deviations between eGFR and DTPA GFR (mean, -1.5 ml/min/1.73 m 2 ) are in line with 207 potential kidney donors investigated by Chung et al (mean, -1.6 ml/min/1.73 m 2 ) [30]. Notably, as an alternative to plasma creatinine, estimated GFR based on cystatin C has shown significantly closer association with DTPA GFR in the general population [33][34][35][36] and in renal transplant recipients [37].…”

Section: Discussionsupporting

confidence: 81%

Comparison of glomerular filtration rate (GFR) with Tc-99m-DTPA and tubular extraction rate (TER) with Tc-99m-MAG3 in potential living kidney donors: Feasibility of a one-day protocol

et al. 2019

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Aim Sufficient glomerular filtration rate (GFR) is mandatory in living kidney donors (LKD) before renal transplantation (RT). Guidelines recommend exogenous GFR (e. g. Tc-99m-DTPA) besides estimated GFR by plasma creatinine (eGFR). Tc-99m-MAG3 determines split function and tubular extraction rate (TER). This study evaluated a time-efficient one-day protocol for DTPA and MAG3 in potential LKD. Methods Retrospective analysis of 82 consecutive potential LKD (female, 52; age, 54 [19–73] a). DTPA GFR (Fleming formula) with blood sampling 169 (147–205) min post injection of 27 (18–59) MBq Tc-99m-DTPA. 199 (181–219) min after DTPA injection, same-day renal scintigraphy with 105 (65–150) MBq MAG3 followed (TER according to Bubeck). Sufficient GFR for RT was defined age- and sex-dependent based on British guidelines, normal TER at 70 % of age-dependent average. In 15 separate potential LKD, a blank blood sample before MAG3 injection allowed estimation of remaining DTPA counts and resulting TER error. Results Remaining Tc-99m-DTPA blood counts during sampling for MAG3 led to median TER underestimation by 12 (IQR, 8–15) ml/min/1.73 m2. Before blood count correction, 16/82 patients had reduced TER despite sufficient GFRFleming in 13/16 patients. After correction, TER remained reduced in 9/82 patients who all had sufficient GFRFleming. 10/82 patients had insufficient eGFR (CKD-EPI) but sufficient GFRFleming. Correlation coefficient for TER and GFRFleming was ρ = 0.76, for eGFR and GFRFleming ρ = 0.61, and for TER and eGFR ρ = 0.55. Conclusion A one-day protocol for Tc-99m-DTPA GFR and MAG3 dynamic imaging is feasible. If TER is calculated, the proposed method for blood count correction may be applied. However, relevance of the TER remains questionable due to frequent discordance to GFR.

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Section: Discussionsupporting

confidence: 81%

Comparison of glomerular filtration rate (GFR) with Tc-99m-DTPA and tubular extraction rate (TER) with Tc-99m-MAG3 in potential living kidney donors: Feasibility of a one-day protocol

et al. 2019

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“…When the GFR >30 mL/min/1.73 m 2 , the clearance of 99m Tc-DTPA and 51 Cr-EDTA is reliable and shows good correlation (12). Garcia-Covarrubias et al also reported that the GFR measured by Gates' method in renal allograft donors was strongly correlated with that estimated by Cystatin C clearance (13). In 1996, 99m Tc-DTPA double plasma sample method was recommended by the American Nuclear Medical Association as the gold standard for the clinical determination of GFR (6).…”

Section: Introductionmentioning

confidence: 95%

Establishment of normal reference ranges for total and separate glomerular filtration rates in living kidney donors by Gates’ method after renal depth measured using single-photon emission computed tomography/computed tomography

Wei¹,

Liu²,

Li³

et al. 2020

Quant Imaging Med Surg

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Background: The underestimation of renal depth by Tønnesen formula in Gates' method, which has been confirmed by many scholars, leads to the underestimation of both separate glomerular filtration rate (gSGFR) and total glomerular filtration rate (gTGFR). This study aimed to establish the normal reference ranges of renal depth-calibrated gTGFR and gSGFR in Chinese healthy adults, and to analyze the influencing factors. Methods: Renal depth was measured by CT scan followed by technetium 99m-diethylene triamine pentaacetic acid ( 99m Tc-DTPA) renal dynamic imaging by single-photon emission computed tomography/ computed tomography (SPECT/CT) in 329 living kidney donors. The renal depth-calibrated gTGFR and gSGFR were calculated by Gates' method with renal depth measured by CT instead of being calculated by the Tønnesen formula. A general linear model based on age, gender, body height, body weight, and BMI was used to analyze factors influencing gSGFR (L), gSGFR (R) and gTGFR. Results: The average gSGFR (L), gSGFR (R), and gTGFR for patients aged 23-64 years old were 49.3±10.1, 49.9±10.4, and 99.1±18.7 mL/min/1.73 m 2 , respectively. The gSGFR (L), gSGFR (R)and gTGFR for patients aged 41-50 years old were 26.9-69. 3, 27.7-68.8, and 57.5-135.3 mL/min/ 1.73 m 2 , respectively, and those for patients aged 51-60 years old were 31.0-61.5, 29.5-63.3, and 64.6-120.7 mL/min/1.73 m 2 , respectively. gSGFR (L), gSGFR (R) and gTGFR had statistical significance with body height and age (P<0.05); however, there was no significant difference with gender, body weight, and BMI (P>0.05). For each 1 year increase in age, the gSGFR (L), gSGFR (R), and gTGFR decreased by 0.17, 0.28, and 0.44 mL/min/1.73 m 2 , respectively, while for every 1 cm increase in body height, the gSGFR (L), gSGFR (R), and gTGFR decreased by 0.37, 0.36, and 0.74 mL/min/1.73 m 2 , respectively.Conclusions: Normal reference ranges for renal depth-calibrated gSGFR (L), gSGFR (R), and gTGFR were established in healthy Chinese adults aged 23-64 years, and gSGFR (L), gSGFR (R), and gTGFR decreased with age and body height.

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Computed Tomography Parameters and Estimated Glomerular Filtration Rate Formulas for Peridonation Living Kidney Donor Assessment

Rasała

Szczot

Kościelska‐Kasprzak

et al. 2020

Transplantation Proceedings

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Correlation of the Glomerular Filtration Rate Measured With the Use of DTPA-Tc99m in Live Kidney Donors With Equations Based on Creatinine and Cystatin C

Cited by 7 publications

References 21 publications

Comparison of glomerular filtration rate (GFR) with Tc-99m-DTPA and tubular extraction rate (TER) with Tc-99m-MAG3 in potential living kidney donors: Feasibility of a one-day protocol

Comparison of glomerular filtration rate (GFR) with Tc-99m-DTPA and tubular extraction rate (TER) with Tc-99m-MAG3 in potential living kidney donors: Feasibility of a one-day protocol

Establishment of normal reference ranges for total and separate glomerular filtration rates in living kidney donors by Gates’ method after renal depth measured using single-photon emission computed tomography/computed tomography

Computed Tomography Parameters and Estimated Glomerular Filtration Rate Formulas for Peridonation Living Kidney Donor Assessment

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