Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency

Butts, Samantha; Riethman, Harold; Ratcliffe, Sarah J.; Shaunik, Alka; Coutifaris, Christos; Barnhart, Kurt T.

doi:10.1210/jc.2008-2269

Cited by 112 publications

(87 citation statements)

References 65 publications

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“…Human tissues often display age-dependent telomere shortening (Keefe & Liu 2009, Takubo et al 2010. A lack of GC TA has been found to be associated with occult ovarian insufficiency (Butts et al 2009). Our previous study suggested that patients with higher levels of TA in the GCs had a greater likelihood of becoming pregnant than those with less TA.…”

Section: Discussionmentioning

confidence: 99%

Telomerase activity is more significant for predicting the outcome of IVF treatment than telomere length in granulosa cells

Wang¹,

Chen²,

Li³

et al. 2014

Reproduction

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Our previous study has demonstrated that luteinized granulosa cells (GCs) have the potential to proliferate and that the telomerase activity (TA) of luteinized GCs may predict the clinical outcomes of IVF treatment. However, in the field of telomere research, there have always been different opinions regarding the significance of TA and telomere length (TL). Thus, in the present study, we compared the effects of these two parameters on IVF treatment outcomes in the same individuals. TL did not differ significantly between the pregnant group and the non-pregnant group. The TA, number of retrieved oocytes and rate of blastocyst transfer were significantly higher in the pregnant group than in the non-pregnant group (0.8825 OD!mm, 12.75G2.20 and 34.48%, respectively, in the pregnant group vs 0.513 OD!mm, 11.60G0.93 and 14.89%, respectively, in the non-pregnant group (P!0.05)), while basal FSH level was lower in the pregnant group than in the non-pregnant group. The subjects did not differ with regard to ovarian stimulation or other clinical characteristics. A TA increase of 1 OD!mm increased the chance of becoming pregnant 4.769-fold (odds ratio: 5.769, 95% CI: 1.434-23.212, P!0.014). The areas under the receiver operating characteristic curves were 0.576 for TL and 0.674 for TA (PZ0.271 and P!0. 012 respectively). The corresponding cut-off points were 4.470 for TL and 0.650 OD!mm for TA. These results demonstrate that TA is a better predictor of pregnancy outcomes following IVF treatment than TL. No other clinical parameters, including age, baseline FSH level or peak oestradiol level, distinguished between the pregnant group and the non-pregnant group as effectively as TA.

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Section: Discussionmentioning

confidence: 99%

Telomerase activity is more significant for predicting the outcome of IVF treatment than telomere length in granulosa cells

Wang¹,

Chen²,

Li³

et al. 2014

Reproduction

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“…Moreover, it was showed that the relative telomere length was longer in GCs from mature oocytes compared with GCs from immature oocytes in human [12]. In addition, the abnormal telomere lengths in GCs were confirmed to be related to the female infertility and diminished ovarian reserve [10]. It was shown that luteinized human GCs have a certain potential for proliferation and that telomerase activity of luteinized GCs may predict the clinical outcomes of in vitro fertilization [11].…”

Section: Telomerase Activity and Stemness In Granulosa Cellsmentioning

confidence: 96%

Plasticity of granulosa cells: on the crossroad of stemness and transdifferentiation potential

Dzafic

Štimpfel

Virant‐Klun

2013

J Assist Reprod Genet

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The ovarian follicle represents the basic functional unit of the ovary and consists of an oocyte, which is surrounded by granulosa cells (GCs). GCs play an important role in the growth and development of the follicle. They are subject to increased attention since it has recently been shown that the subpopulation of GCs within the growing follicle possesses exceptionally plasticity showing stem cell characteristics. In assisted reproduction programs, oocytes are retrieved from patients together with GCs, which are currently discarded daily, but could be an interesting subject to be researched and potentially used in regenerative medicine in the future. Isolated GCs expressed stem cell markers such as OCT-4, NANOG and SOX-2, showed high telomerase activity, and were in vitro differentiated into other cell types, otherwise not present within ovarian follicles. Recently another phenomenon demonstrated in GCs is transdifferentiation, which could explain many ovarian pathological conditions. Possible applications in regenerative medicine are also given.

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“…Hence, it is highly likely for ovarian somatic cells (granulosa and theca cells) to also undergo cellular senescence. Short telomeres and low telomerase activity in granulosa cells are observed in women (≤37 years old) with diminished ovarian reserve (Butts et al 2009). In humans, shortened telomere length in cumulus cells, which are specialized granulosa cells, is associated with the development of poor embryos (Cheng et al 2013).…”

Section: Cellular Senescence and Ovarian Agingmentioning

confidence: 99%

Positive and negative effects of cellular senescence during female reproductive aging and pregnancy

Velarde

Menon

2016

Journal of Endocrinology

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Cellular senescence is a phenomenon occurring when cells are no longer able to divide even after treatment with growth stimuli. Because senescent cells are typically associated with aging and age-related diseases, cellular senescence is hypothesized to contribute to the age-related decline in reproductive function. However, some data suggest that senescent cells may also be important for normal physiological functions during pregnancy. Herein, we review the positive and negative effects of cellular senescence on female reproductive aging and pregnancy. We discuss how senescent cells accelerate female reproductive aging by promoting the decline in the number of ovarian follicles and increasing complications during pregnancy. We also describe how cellular senescence plays an important role in placental and fetal development as a beneficial process, ensuring proper homeostasis during pregnancy.

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Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency

Abstract: Aberrant telomere homeostasis is associated with occult ovarian insufficiency in young women. This finding is consistent with the presence of telomeric attenuation that has been shown in multiple age-related conditions.

Cited by 112 publications

References 65 publications

Telomerase activity is more significant for predicting the outcome of IVF treatment than telomere length in granulosa cells

Telomerase activity is more significant for predicting the outcome of IVF treatment than telomere length in granulosa cells

Plasticity of granulosa cells: on the crossroad of stemness and transdifferentiation potential

Positive and negative effects of cellular senescence during female reproductive aging and pregnancy

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