Correlation of Serum Uric Acid with Disease Activity and C-Reactive Protein in Patients Suffering from Rheumatoid Arthritis

Ghosh, Bikash Chandra; Baidya, Debasish; Halder, Pampa; Mandal, Shamash

doi:10.4236/ojra.2016.63013

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…This could be explained by the long disease duration and that our patients were already on DMARDs which control the disease activity and at the same time has great effect on level of serum uric acid. Alternatively, Ghosh et al (13) found a positive correlation between serum UA and clinical disease activity index and hs-CRP with extremely high statistical significance in 120 newly diagnosed DMARD naive RA patients of them 36 patients were males.…”

Section: Discussionmentioning

confidence: 99%

Evaluation Of The Relationship between Serum Uric Acid and Bone Mineral Density In Rheumatoid Arthritis Male Patients

Salman

Galbat

2021

The Egyptian Journal of Hospital Medicine

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Background: Hyperuricemia is a common risk factor for conditions associated with oxidative stress. Alternatively, there is increasing evidence that normal serum uric acid (UA) plays a protective role as an antioxidant. Osteoporosis was commonly attributed to oxidative stress and is a common complication of rheumatoid arthritis (RA). Objectives: To study the relationship between serum UA and bone mineral density in male patients with rheumatoid arthritis. Patients and methods: Fifty RA male patients were included in this study. Age, disease duration, and type of medication were recorded. Clinical examination for tender and swollen joints was done and disease activity score 28 was calculated. Body mass index, random blood glucose, erythrocyte sedimentation rate, C-reactive protein, serum UA, rheumatoid factor and anti-CCP were measured. Bone mineral density was measured using dual-energy X-ray absorptiometry at the lumbar spine, hip and radius. Results: A highly significant positive correlation between serum UA and T scores in the lumbar spine and hip. However, serum UA was negatively correlated with disease activity, ESR and CRP (P < 0.001). There was significant (P < 0.001) association between serum UA and different therapeutic agents (levels of serum UA were higher in patients taking combined biological and conventional disease modifying anti-rheumatic drugs (DMARDs) than those who were taking biological or conventional DMARDs alone. Conclusion:High normal serum UA level is protective against osteoporosis at both the lumbar spine and hip in male rheumatoid arthritis patients. Also, serum UA level is negatively correlated with RA disease activity and acute phase reactants in male patients with RA.

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Section: Discussionmentioning

confidence: 99%

Evaluation Of The Relationship between Serum Uric Acid and Bone Mineral Density In Rheumatoid Arthritis Male Patients

Salman

Galbat

2021

The Egyptian Journal of Hospital Medicine

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“…The rheumatoid factor (RF) monitors the presence of an antibody in most patients with RA [ 90 ]. Interestingly, for inflammatory arthritis, uric acid and CRP increase in gout [ 91 ]. On the other hand, biomarkers may allow for the diagnosis of inflammatory arthritis at early stages of the disease.…”

Section: Nanomaterials For the Diagnosis Of Inflammatory Arthritismentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah

Barani

Rahdar

et al. 2021

IJMS

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Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.

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Tumor necrosis factor-α -308 polymorphism in North Indian rheumatoid arthritis patients and association with mRNA and serum TNF-α

et al. 2017

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Rheumatoid arthritis (RA) is a severely disabling chronic autoimmune disorder that leads to progressive inflammation of the joints and surrounding tissues. TNF-α, a potent proinflammatory cytokine, plays a pivotal role in the pathogenesis of RA. The endogenous formation of TNF-α may be influenced by TNF-α promoter polymorphisms. Hence, the present study was designed to explore any possible association between genetic polymorphism of TNF-α -308 G/A, messenger RNA (mRNA) expression, serum levels of TNF-α, and inflammatory markers in North Indian RA patients. A total of 214 controls and 187 RA patients were recruited according to the revised American College of Rheumatology 2010 criteria. TNF-α -308 G/A genetic polymorphism within promoter region was analyzed by using PCR-RFLP. Levels of inflammatory markers and serum TNF-α were estimated by ELISA. The mRNA expression of TNF-α gene was measured by quantitative real-time PCR. Higher levels of autoantibodies (RF and anti-CCP) were present in RA patients as compared to controls. We found a positive and significant correlation of circulating TNF-α levels with RF (r = 0.18), anti-CCP (r = 0.16), and mRNA expression of TNF-α gene (r = 0.57) in RA patients. The mRNA expression levels of TNF-α was 4.5-fold higher in patients with RA as compared to controls. The heterozygous mutant variants (G/A) and homozygous mutant variants (A/A) were found to be significantly associated with RA as compared to control (OR = 1.52 and 3.02, respectively). Our observations illustrated a significant association of allele -308 A TNF-α with progression of RA. Significant and positive correlation of TNF-α levels with mRNA expression and inflammatory marker levels suggests that serum TNF-α may be a susceptibility marker for RA.

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Correlation of Serum Uric Acid with Disease Activity and C-Reactive Protein in Patients Suffering from Rheumatoid Arthritis

Cited by 6 publications

References 7 publications

Evaluation Of The Relationship between Serum Uric Acid and Bone Mineral Density In Rheumatoid Arthritis Male Patients

Evaluation Of The Relationship between Serum Uric Acid and Bone Mineral Density In Rheumatoid Arthritis Male Patients

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Tumor necrosis factor-α -308 polymorphism in North Indian rheumatoid arthritis patients and association with mRNA and serum TNF-α

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