Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children

Abstract

Background: Allergic rhinitis (AR) is a distressing clinical presentation especially in pediatric age which affects quality of life and may predispose to bronchial asthma. Various inflammatory biomarkers might be involved in allergic rhinitis pathogenesis and correlated with its severity such as IL1 β and CCL 24. Objectives: This study aims to detect serum level of IL 1 β and CCL24 in studied pediatric patients and correlate their levels with the severity of allergic rhinitis and with comorbid asthma in children. Methodology: Peripheral blood eosinophil count was detected and serum level of IgE, IL1 β and CCL24 were assayed in pediatric patients with allergic rhinitis using ELISA. In addition, correlation of their levels with the severity of AR. Results: Eosinophil count and serum levels of IL1 β and CCL24 were significantly elevated in (AR) patients compared with the controls (P=0.00001*), (P=0.026*) and (P=0.017*) respectively. Parental smoking and Associated Asthma of high statistical significance when correlated with severity of allergic rhinitis (P=0.005) and (P<0.001) respectively. Family history of allergy& allergy in other sibling were also significantly correlated with severity of AR (P=0.093) and (P=0.02) respectively. Conclusion: This study clarifies the evidence that IL-1β is an important inflammatory biomarker for pathogenesis and severity of allergic rhinitis and it might predispose to other allergic diseases subsequently it may be investigated as a therapeutic target especially in severe cases.