Correlation of serum lactate dehydrogenase and pregnancy induced hypertension with its adverse outcomes

Andrews, L. John; Patel, Nikunj

doi:10.18203/2320-6012.ijrms20161112

Cited by 12 publications

(15 citation statements)

References 8 publications

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“…This indicates increase in preterm deliveries in patients with higher LDH levels. This finding is comparable with study done by Jaiswar SP et al, Qublan et al, Umasatyasri Y et al and Liggy A et al 7,8,10,11 The mean Apgar scores were significantly reduced at 1 min and 5 min, in the present study, showing mild to severe depression of the newborn baby with increasing LDH levels (p<0.05) for Apgar score at 1 and 5 min respectively.…”

Section: Discussionsupporting

confidence: 92%

“…[7][8][9][10] In the present study the LDH levels were significantly raised with the severity of the disease (P<0.001) and this was in accordance with the study done by Jaiswar SP et al, Qublan et al and Liggy A et al 7,8,11 The mean gestational age at the time of delivery in the present study was significantly less in patients with increasing LDH levels (P<0.05). This indicates increase in preterm deliveries in patients with higher LDH levels.…”

Section: Discussionsupporting

confidence: 91%

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Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia, Gujarat

Jain¹,

Upadhyay²,

Mehta³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Serum LDH levels can be used to assess the extent of cellular death and thereby the severity of disease in this group of women. This will help in making decision, about the management guidelines to the better the maternal and fetal outcome. Objective of present study was compare serum LDH levels in the normal pregnant women and in women with preeclampsia and eclampsia in ante-partum period and to study the association of maternal and perinatal outcomes with serum LDH levels.Methods: It is a prospective study done at Obstetrics and Gynecology department, GMERS medical college and civil hospital, Gandhinagar during August-September 2016. Participants were divided into four groups according to severity of disease and into three groups according to serum LDH level.Results: Mean level of LDH (IU/l) in Control, Mild pre-eclampsia, Severe pre-eclampsia & Eclampsia was 302.33, 398.56, 675.26 & 1589.85 respectively. Out of total 34 cases with LDH level >800 IU/L, 47.1% cases had ≥160 mm hg SBP & 52.9% had ≥110 mm hg DBP, mean gestational age and mean baby weight was 36.88 week and 1950 gm, mean apgar score at 10 min was 6.96, 47.1% had uneventful outcome, whereas 58.8% had neonatal complications and 5.9% had neonatal death. Almost 26.5% still births, 47.1% perinatal deaths.Conclusions: Higher serum LDH levels during pregnancy have significant association with severity of disease and maternal and fetal outcomes in patients of preeclampsia and eclampsia and can be considered as a supportive prognostic tool from early third trimester.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia, Gujarat

Jain¹,

Upadhyay²,

Mehta³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…7,8,15,18,19 It is evident from present study that progressively increased LDH level in severe preeclampsia indicates progression of cellular injury with severity of this disorder as supported by Sarkar et al 8 Progressively raising LDH correlates with worsening of preeclampsia, maternal and foetal complications as supported by many studies. 7,8,[11][12][13][14][15]18 CONCLUSION From the present study, it can be concluded that elevated high serum LDH levels significantly correlate with the severity of preeclampsia. Hence, estimation of LDH in preeclampsia serves as a prognostic tool which is useful for early diagnosis and timely management to reduce maternal and foetal morbidity and mortality.…”

Section: Discussionsupporting

confidence: 62%

Evaluation of Lactate Dehydrogenase- A Biochemical Marker of Preeclampsia

Dev¹,

Hemalatha²

2017

jemds

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“…Andrews L et al 18 conducted a study to assess significance of the value of serum LDH as a marker of Pregnancy Induced Hypertension and its severity. Total 110 cases were studied, 40 were normal pregnant women and remaining 70 were PIH cases.…”

Section: Groupmentioning

confidence: 99%

To Study Levels of LDH in Normal Pregnancy, Pre-Eclampsia & Eclampsia

Kulkarni¹,

Shaikh²

2019

jemds

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BACKGROUND Hypertension during pregnancy is a major health problem. Hypertensive disorders of pregnancy (preeclampsia, eclampsia) are common medical complications and affect 10% pregnancies. These pregnancies are at increased risk for maternal complications like abruption, disseminated intravascular coagulation, HELLP syndrome, pulmonary oedema, stroke, hepatic failure and renal failure. Foetal complications include growth restriction, prematurity and death of foetus. Early screening of gestational hypertension and preeclampsia may reduce the maternal and foetal complications. METHODS We conducted this study of levels of LDH in normotensive pregnancy, preeclampsia and eclampsia. This is a hospital based comparative cross-sectional study conducted in the department of Obstetrics & Gynaecology, Bharati Vidyapeeth Medical College and Hospital, Sangli, from December 2015 to July 2017. Out of a total of 150 patients included in present study, 50 patients were in normotensive group, 50 in preeclampsia group and 50 were in eclampsia group. Along with blood investigations, LDH levels were studied in all three groups. RESULTS Mean LDH was 257.24 U/L in normotensive patients as compared to 417.84 U/L in patients with pre-eclampsia and 565.51 in patients with eclampsia. LDH levels were found to be raised in pre-eclampsia and eclampsia patients and was statistically significant. CONCLUSIONS Serum LDH is the earliest marker in blood during hypoxia and oxidative stress. It is raised in cases of pre-eclampsia and eclampsia. Detection of high-risk patients with increased levels of LDH mandates close monitoring, prompt and correct management to decrease both maternal and foetal morbidity and mortality. Estimation of serum Lactate Dehydrogenase can be used as a prognostic marker for preeclampsia and eclampsia.

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Correlation of serum lactate dehydrogenase and pregnancy induced hypertension with its adverse outcomes

Cited by 12 publications

References 8 publications

Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia, Gujarat

Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia, Gujarat

Evaluation of Lactate Dehydrogenase- A Biochemical Marker of Preeclampsia

To Study Levels of LDH in Normal Pregnancy, Pre-Eclampsia & Eclampsia

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