Correlation of Serum Homocysteine Levels with the Severity of Coronary Artery Disease

Belle, Vijetha Shenoy; Mehendale, Veena; Prabhu, Krishnananda; Shetty, Ranjan; Rao, P. L. N. G.

doi:10.1007/s12291-013-0373-5

Cited by 101 publications

(101 citation statements)

References 21 publications

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“…Most prospective and retrospective studies have demonstrated that high homocysteine is an independent risk factor for CAD [7]. Previous studies have shown that high rates of CAD in Asian Indians are associated by high prevalence of conventional risk factors such as hypercholesterolemia, hypertension, and smoking [4].…”

Section: Discussionmentioning

confidence: 99%

“…Molecular deficiency in each of these enzymes can cause hyperhomocysteinemia. Several studies discovered that homocysteine levels are associated with a novel risk factor for CAD and premature atherosclerosis [7]. However, the mechanism of atherosclerosis plaques correlated with hyperhomocysteinemia is not clearly stated.…”

mentioning

confidence: 99%

“…The factors which influence the level of homocysteine may vary significantly in a population with age, genetics, and nutrition [10]. Elevated homocysteine levels are associated with some factor including increasing age, male sex, smoking, coffee consumption, high blood pressure, lipid profile, high creatinine and improper diet [7]. Low folate and vitamin B12 are related with elevated homocysteine levels [11].…”

mentioning

confidence: 99%

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Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

Ranjith¹,

P²

2017

WJCD

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Objective: The aim of this study was to evaluate correlation between plasma homocysteine and coronary artery disease (CAD) in Indian patients. Methods: This study included 150 patients, 100 subjects in study group with angiographically diagnosed CAD and 50 subjects in control group with a normal coronary angiogram. In the study group, patients were divided into three subgroups viz.: CAD only, CAD with hypertension and CAD with type 2 diabetes mellitus. Plasma homocysteine, lipid profile and other risk factors were compared. Results: Mean homocysteine levels in study group (38.34 ± 15.25 μmol/L) were significantly higher (p < 0.01) than control group (9.41 ± 4.22 μmol/L). No association was found between homocysteine level and conventional risk factors. Furthermore, no significant correlation was found between plasma homocysteine and lipid components in different groups of patients. Conclusion: The study demonstrated that increased levels of homocysteine are independently related to CAD. However, further studies involving a larger sample size will be required to substantiate the findings of the current study.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

Ranjith¹,

P²

2017

WJCD

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“…It is hard to say that CVD function is specific. Importance of coronary artery disorders could be divided to single, double and triple vessel disorders (Shenoy et al, 2014). It has known that Hcy played specific role in atherosclerotic vascular abnormalities since 1990s (McCully, 1996).…”

Section: Relationship Between Homocysteine and Cardiovascular Diseasementioning

confidence: 99%

“…It has known that Hcy played specific role in atherosclerotic vascular abnormalities since 1990s (McCully, 1996). Evidence has indicated a connection between mild increased Hcy amounts also possibility of CVD (heart, peripheral artery, coronary and cerebrovascular disorders) (Shenoy et al, 2014). Arteriosclerosis is defined as a consecutive inflammatory hurt to intima of artery with increase discharging of plasma, sedimentation of plasma lipids in fibrosis and plaques grading (Schaffer et al, 2014).…”

Section: Relationship Between Homocysteine and Cardiovascular Diseasementioning

confidence: 99%

Homocystein: A new biochemical marker in livestock sector

Kozat

Okman

2017

J Adv Vet Anim Res

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The livestock sector is making great contributions to the world economy. Many different diseases, such as cardiovascular diseases, kidney and mineral substance insufficiency, cause huge losses in yield and production in the livestock sector. Early diagnosis is essential to combat these diseases. Today, homocysteine levels are used as biochemical markers in the diagnosis of the functions and diseases of many different organs in human medicine. Homocysteine is an amino acid that occurs in the process of methionine metabolism and does not enter the primary structure of proteins. Homocysteine is a biochemical marker used in the assessment of cardiovascular and renal diseases as well as other organ functions. In this review, homocysteine determination methods and detailed information about which organ and system diseases can be used in livestock sector will be given.

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Cysteine and homocysteine as biomarker of various diseases

Rehman

Shabbir

Inam‐Ur‐Raheem

et al. 2020

Food Science & Nutrition

140

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Cysteine and homocysteine (Hcy), both sulfur‐containing amino acids (AAs), produced from methionine another sulfur‐containing amino acid, which is converted to Hcy and further converted to cysteine. This article aims to highlight the link between cysteine and Hcy, and their mechanisms, important functions, play in the body and their role as a biomarker for various types of diseases. So that using cysteine and Hcy as a biomarker, we can prevent and diagnose many diseases. This review concluded that hyperhomocysteinemia (elevated levels of homocysteine) is considered as toxic for cells and is associated with different health problems. Hyperhomocysteinemia and low levels of cysteine associated with various diseases like cardiovascular diseases (CVD), ischemic stroke, neurological disorders, diabetes, cancer like lung and colorectal cancer, renal dysfunction‐linked conditions, and vitiligo.

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Correlation of Serum Homocysteine Levels with the Severity of Coronary Artery Disease

Abstract: Coronary artery disease (CAD) has become the most common cause of mortality in the entire world.

Cited by 101 publications

References 21 publications

Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

Homocystein: A new biochemical marker in livestock sector

Cysteine and homocysteine as biomarker of various diseases

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