Correlation of serum and salivary CA15-3 levels in patients with breast cancer

Agha‐Hosseini, Farzaneh; Mirzaii‐Dizgah, Iraj; Rahimi, Asieh

doi:10.4317/medoral.14.e521

Cited by 83 publications

(60 citation statements)

References 16 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In present study, the average concentration of CA15-3 was significantly higher in breast cancer patients than normal's (p=0.00). This finding is consistent with other reports (Keyhani et al, 2005;Agha-Hosseini et al, 2009).…”

Section: Discussionsupporting

confidence: 94%

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Moazzezy¹,

Farahany²,

Oloomi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: CEA and CA 15.3 serum tumor markers are currently used in clinical practice for monitoring therapy. The aim of this study was to evaluate serum level of these markers among healthy females and invasive breast carcinoma (IBC) patients and to determine any relationships with clinicopathological factors. Materials and Methods: 60 Iranian females were enrolled in this study, 30 healthy and 30 diagnosed with breast cancer who had not received any preoperative chemotherapy or hormone therapy. Enzyme linked immunosorbent assays were used for the quantitative determination of the cancer associated antigens, CEA and MUC1 (CA15-3). Results: The serological levels of CEA and CA15-3 (5.0033±0.49 µg/L and 178.1667±15.11 U/ml) in the breast cancer patients were significantly higher (p=0.00) than the serum levels of normal controls (1.1237±0.11 µg/L and 21.13±3.058 U/ml). Regarding the CEA marker, a significant correlation with grade of tumor was shown. Furthermore, there was a low correlation between CA15-3 and CEA marker with correlation coefficient r=0.08. Conclusions: Collectively, markedly high levels of CEA and CA15-3 were found in our patients, pointing to their use as additional tools after clinical diagnosis.

show abstract

Section: Discussionsupporting

confidence: 94%

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Moazzezy¹,

Farahany²,

Oloomi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…In addition, the CA 15-3 concentration in serum and saliva according to the lymph node status, the extension of the breast cancer, did not show difference between patients with positive status and healthy volunteers considered as negative statue additionally to patients with negative status. This data is opposite to the results found in similar studies (Colomer et al, 1989;Streckfus et al, 1999;Agha-Hosseini et al, 2009) whom found a significant difference in the early stages between patients and healthy volunteers. However, a positive and significant correlation was found between the salivary and serum CA 15-3 concentration (r=0.27, p=0.03).…”

Section: Discussioncontrasting

confidence: 57%

“…However, a positive and significant correlation was found between the salivary and serum CA 15-3 concentration (r=0.27, p=0.03). The correlation found in our data is low comparing to the moderate correlation found in previous works (Streckfus et al, 1999;Agha-Hosseini et al, 2009).…”

Section: Discussioncontrasting

confidence: 54%

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Laidi

Bouziane²,

Lakhdar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

The tumor marker CA 15-3 is one of the most import reliable for metastatic breast cancer monitoring. While it is generally assessed in serum of patients, blood sampling is an invasive method compared to saliva sampling which is simple and could be an alternative to blood according to many studies. The aim of this investigation was to assess the relationship between serum and salivary concentrations of the protein CA 15-3 in patients with breast cancer and healthy asymptomatic volunteers. A case-control study was conducted with 60 women: 29 breast cancer patients from the Maternity Hospital Souissi Rabat (Morocco) and 31 healthy asymptomatic women. The CA 15-3 concentrations in saliva and serum samples were assessed using an enzyme immune assay (EIA kits) and comparison between cases and controls was made by the Mann-Whitney test. The correlation between serum and saliva CA 15-3 concentration was tested using Pearson correlation. The comparison result of CA15-3 concentration in saliva and serum level in cases and controls was not statistically significant (p>0.05). However, the correlation between salivary and serum CA 15-3 concentration was positive and statistically significant (r=0.27, p=0.03). In conclusion, the positive correlation between salivary and serum expression found in our study suggests that saliva could be an alternative to blood sampling to help breast cancer monitoring.

show abstract

“…Salivary biomarkers are used for screening purposes in epidemiological studies [13] and are being used to monitor and detect various diseases, such as breast cancer [14], lung cancer [15], celiac disease [16], and chronic renal failure [11]. With regard to oral health, three important salivary variables should be investigated: pH, flow velocity, and buffering capacity.…”

Section: Discussionmentioning

confidence: 99%

Associação entre a diminuição do nível de ferro salivar e a experiência de cárie em crianças

Buche¹,

Gusso²,

Torres³

et al. 2017

Rev. Odonto Ciênc. (Online)

View full text Add to dashboard Cite

OBJECTIVE: Human saliva has numerous components that are important for maintaining oral health. We investigated the association between iron levels in saliva in children and their caries experience. METHODS: We conducted a case-control study that included 186 healthy children, aged 11-14 years. The decayed-filled teeth/decayed-missing-filled teeth (DMFT) score was estimated according to the Brazilian Oral Health Project. The children were divided into two groups: caries-free group (DMFT=0, n=55) and caries experience group (DMFT≥1, n=131). Saliva was collected from each child using the spitting method and analyzed for stimulated saliva flow (SSF), pH, and iron levels. The SSF, pH, and salivary iron levels were analyzed for statistical assumptions of normality and homoscedasticity and compared between groups. All of the statistical tests were performed using R and SPSS software, with a level of significance of 0.05. RESULTS: No statistically significant differences in mean pH were found between groups (t=-0.0488, p=0.51). Children with caries experience had significantly lower salivary iron levels than caries-free children (w=5088, p<0.0001). The SSF values were significantly different between children with caries experience and children without caries (w=4198, p=0.03). CONCLUSION: Salivary iron levels were significantly lower in children with dental caries experience, suggesting that salivary iron plays a role in maintaining oral health.Key words: Saliva; Salivary iron; Caries Associação entre a diminuição do nível de ferro salivar e a experiência de cárie em crianças RESUMO OBJETIVO: Investigar a associação entre os níveis de ferro na saliva das crianças e sua experiência de cárie. MÉTODOS: Realizamos um estudo caso-controle envolvendo 186 crianças saudáveis de 11 a 14 anos. O número de dentes cariados, perdidos e obturados (CPO-D) foi estimado de acordo com o Projeto Saúde Bucal Brasil (SBBrasil) e as crianças foram divididas em dois grupos: grupo sem cárie (CPO-D=0; n=55) e experiência Grupo de cárie (CPO-D≥1; n=131). A saliva foi coletada de cada indivíduo usando o método de cuspir e analisada quanto ao fluxo estimado de saliva (SSF), pH e concentração de ferro. As variáveis SSF, pH e ferro salivar foram analisadas pelos pressupostos estatísticos de normalidade e homocedasticidade e comparados entre os grupos. Todos os testes foram realizados utilizando os programas estatísticos R (R Core Team, 2016) e SPSS (IBM, EUA), assumindo um nível de significância de 0,05. RESULTADOS: Não houve diferenças estatisticamente significativas entre os meios de pH entre os grupos (t=-0,0488; p=0,51). Em relação ao ferro salivar, as crianças com experiência em cárie apresentaram valores significativamente mais baixos de ferro salivar do que aqueles que não apresentavam caries (w=5088; p<0,0001). Além disso, os valores de SSF foram diferentes entre as crianças com experiência de cárie e aqueles sem cárie (w=4198; p=0,03). CONCLUSÃO: os níveis de ferro salivar foram estatisticamente inferiores em crianças com cárie den...

show abstract

Correlation of serum and salivary CA15-3 levels in patients with breast cancer

Cited by 83 publications

References 16 publications

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Associação entre a diminuição do nível de ferro salivar e a experiência de cárie em crianças

Contact Info

Product

Resources

About