Correlation of Resistin with Inflammatory and Cardiometabolic Markers in Obese Adolescents with and without Metabolic Syndrome

Abstract

Objective: The link between plasma resistin and obesity-related cardiometabolic disorders in children remains debatable. This study assessed the relationships of plasma resistin with cardiovascular risk factors, pro-inflammatory markers and insulin resistance index (HOMA-IR) in obese (Ob) adolescents and obese adolescents with metabolic syndrome (Ob-MS) compared to healthy controls (CO). Methods: 114 obese adolescents (60 Ob, age 13.6 ± 0.9 years, BMI 28.0 ± 2.2 kg/m², and 54 Ob-MS, age 13.8 ± 1.0 years, BMI 32.5 ± 4.8 kg/m²) and 37 CO (age 13.7 ± 0.8 years, BMI 22.8 ± 0.8 kg/m²) were studied. Anthropometrics, cardiac variables as well as fasting plasma concentrations of lipids, glucose, insulin, and adipocytokines (resistin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP)) were measured. HOMA-IR was calculated, and the presence of MS was assessed. Results: Plasma resistin was significantly higher in Ob-MS than in both Ob and CO and was correlated with anthropometric, cardiovascular, pro-inflammatory markers and several components of MS as was HOMA-IR in Ob and Ob-MS. With increasing the number of MS components, plasma resistin, pro-inflammatory markers, and HOMA-IR were also increased. Multiple regression models highlighted significant correlation between resistin and both HOMA-IR (r = 0.40, p < 0.05) and systolic blood pressure (r = 0.63, p < 0.01) in Ob-MS. Conclusion: These results support the hypothesis that there is an association between circulating resistin and childhood obesity-related inflammatory and cardiometabolic events.

Pathophysiology of hypertension in obese children: a systematic review

“…The role of resistin in the development of high blood pressure in obese children is yet unclear. One study did find a significant association between resistin and blood pressure , while another study did not .…”

Asociación de la resistina con variables de dimensión y composición corporal en eutróficos y obesos

“…En el presente trabajo, los niveles de resistina difieren significativamente entre obesos y eutróficos en el género masculino, presentando los obesos la mayor concentración, lo cual es ratificado por la correlación observada entre resistina e IMC en el grupo total y en los obesos por separado. En sujetos de edad pediátrica, se ha reportado diferencia significativa entre eutróficos y obesos [11][12][13][19][20][21][22] y se ha encontrado correlación positiva entre resistina e IMC 9,19,21 , relación que es considerada por algunos autores como fuerte e independiente de la edad, género y estadio puberal, en obesos 22 . Por el contrario, se ha reportado que no existe diferencia significativa en los niveles de resistina entre eutróficos y obesos 1,3,5,9,23,[24][25][26] o correlación entre ambas variables 1,23,25,27 .…”

“…Igualmente algunos trabajos reportan diferencias entre géneros con niveles de resistina mayores en el femenino, sin importar el estado nutricional 9,11,20,25 , en eutróficos y obesos por separado 9 y en los púberes 11 . Sin embargo, otros autores no han podido establecer diferencia entre géneros 1,5,13,21,22 .…”

“…En la presente investigación, al igual que lo reportado por diferentes autores 1,13 , los parámetros CC y IC/Tno mostraron relación con la concentración de resistina, en obesos o en el grupo total de sujetos. Otros investigadores observaron la asociación en sujetos de ambos géneros 11 o evidenciaron correlación, entre resistina y el IC/T y la CC independiente del estado nutricional y en obesos, pero no en controles 3,9,22 .…”

Clinical potential of resistin as a novel prognostic biomarker for cellulitis

“…Serum resistin levels have been observed to increase during severe bacterial and viral infections (6)(7)(8). Furthermore, increased resistin levels have been associated with insulin resistance (9), and a strong correlation has been observed between C-reactive protein (CRP) and resistin (10).…”