Clinical potential of resistin as a novel prognostic biomarker for cellulitis

Abstract

Abstract. Cellulitis is an acute, subacute or chronic inflammation of the dermis and subdermal tissues, which is typically caused by bacteria, although other causes are possible. The present study aimed to evaluate the association between resistin levels and the recovery time of patients with cellulitis. In addition, the effect of resistin and insulin resistance on the prognosis of cellulitis was investigated. In total, 52 patients with cellulitis (male, 21; female, 31) and an age-matched group of 42 healthy individuals (male, 18; female, 24) were included in the study. The levels of serum resistin, fasting plasma glucose (FPG), homeostasis model assessment-insulin resistance (HOMA-IR), C-reactive protein (CRP) and other biochemical parameters were compared between the groups. The mean resistin levels in the cellulitis and control groups were 9.4±5.3 and 5.8±3.1 ng/ml, respectively. The levels of resistin, FPG, HOMA-IR and CRP were significantly higher in the cellulitis group compared with the control group (P<0.001). Furthermore, the mean recovery time of the patients with cellulitis was 21.2±5.6 days. Thus, increased levels of resistin (P=0.002) and HOMA-IR (P=0.005) could be used as predictive factors for the recovery time. The enhanced levels of resistin and HOMA-IR were shown to correlate with the high CRP levels in the cellulitis group. Therefore, the results indicated that increased levels of resistin may function as a prognostic marker for cellulitis.

Novel inflammatory markers of labor following premature preterm rupture of membranes

“…There are some arguments for the importance of resistin as inflammation mediator in humans, such as the wellproven correlation between autoimmune diseases severity and resistin plasma level [42][43][44][45]. In normal pregnancy, resistin level in the pregnant women increases, therefore it can influence maternal-placental-fetal unit maturation [46].…”

Sonographic Detection of Necrotizing Fasciitis

“…Cellulitis is defined as inflammation affecting only the dermal and subdermal layers of soft tissue, while NF has deeper involvement affecting the superficial fascia and subcutaneous tissue. 31,32 The sonographic appearance of cellulitis is greatly dependent on the site and severity of the infection as the appearance can range from a diffuse swelling demonstrated by an increased echogenicity of the skin and subcutaneous tissue to a more variable cobblestone appearance, depending on the amount of fluid, degree of subcutaneous edema, and orientation of the interlobular fat septa. 33 A study conducted by Tsai et al 34 aimed to determine how cellulitis and NF can be differentiated on sonography and found that the sonographic findings of NF include: an irregularity of the fascia, an abnormal fluid collection along the fascial plane, and a diffuse thickening of the fascia when compared with the opposite limb, if unaffected.…”