“Correlation of red blood cell distribution width with the severity of coronary artery disease—A single center study”

Abstract

ObjectiveCoronary Artery Disease (CAD) is the leading cause of morbidity and mortality all around the world. We evaluated the correlation of Red blood cell Distribution Width (RDW) with the severity of lesion on coronary angiography as assessed by Modified Gensini score (MGS) in CAD patients.MethodsA total of 576 consecutive patients admitted in Department of Cardiology over a period of one year, who underwent coronary angiography after diagnosis of CAD or presence of angina like chest pain and/or positive treadmill test were enrolled in the study (August 2014–May 2015). Patients were divided into two groups, with CAD (Group A) and without CAD (Group B). The RDW Cofficience of variance (RDW CV) and RDW standard deviatiton (RDW SD) of each patient, and their correlation with severity of CAD was assessed.ResultsOf the total 576 patients enrolled, 438 were in Group A and 138 were in Group B. The mean age of presentation in Group A and Group B was (53.64 ± 10.36 vs 49.4 ± 9.73) years (p < 0.0001). The Male and Female ratio overall was 2.42:1. Patients in Group A had significantly elevated RDW CV and RDW SD levels compared with those in Group B [(14.59 ± 1.04)% vs (13.6 ± 0.68)%, p < 0.0001], [(45.78 ± 4.76) vs (40.77 ± 3.01), p < 0.0001 respectively]. A significant positive correlation between RDW CV, RDW SD and MGS was noted (r = 0.33, p < 0.0001) (r = 0.43, p < 0.0001) respectively. On multivariate logistic regression analysis, RDW was demonstrated to be an independent predictor for angiographic CAD (OR = 4.17, 95% CI 3.05–5.69, p < 0.0001). On receiver operating characteristic curve (ROC) analysis, an RDW value of 14.3% was identified as an effective cut off point in diagnosing CAD with a sensitivity of 58.9% and specificity of 84.8%.ConclusionsRDW is an independent predictor of CAD and severity of coronary stenosis, suggesting that it can be a readily available marker for prediction and severity of CAD.

Association between mean corpuscular volume and severity of coronary artery disease in the Northern Chinese population: a cross-sectional study

“…23 The RDW was also found to be an independent predictor of CAD and the severity of coronary stenosis. 24 In the present study, we found that patients in the Northern Chinese population with a higher MCV and RDW had higher Gensini scores. Moreover, a linear regression analysis was further performed to test the association between the severity of CAD and the MCV.…”

Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

“…34,35 Studies in adults also showed that increased RDW and RPR are correlated with inflammation. [18][19][20][21]36 The increase in RDW is thought to occur as a result of inflammatory cytokines inhibiting erythrocyte maturation and accelerating the passage of younger and larger reticulocytes into the peripheral circulation. 37 Garofoli et al 22 demonstrated that RDW was significantly higher in preterm infants with PDA, bronchopulmonary dysplasia, and late neonatal sepsis.…”

“…19 RDW and RPR were shown to be indicators of inflammatory status in adult studies. [19][20][21] However, there are limited data on its relationship with neonatal morbidities. 12,22 MPV-to-platelet ratio (MPR) is another indicator of inflammatory status whose relationship with neonatal morbidities has not been investigated.…”

A promising, novel index in the diagnosis and follow‐up of patent ductus arteriosus: Red cell distribution width‐to‐platelet ratio

“…Red blood cell distribution width (RDW) is a parameter that measures the range of variation of red blood cell volume. The critical role of RDW has been revealed in a variety of inflammatory diseases in adults . The normal ranges of RDW values were identified in neonates .…”

“…The critical role of RDW has been revealed in a variety of inflammatory diseases in adults. [12][13][14][15][16] The normal ranges of RDW values were identified in neonates. 17,18 It was shown that there was an inverse relationship between gestational age and RDW, but data on the association of RDW with neonatal morbidities are limited.…”