Correlation of Ratio of Serum Pepsinogen I and II With Prevalence of Gastric Cancer and Adenoma in Japanese Subjects

Yoshihara, Masaharu; Sumii, Koji; Haruma, Ken; Kiyohira, Kuninushi; Hattori, Nobuyuki; Kitadai, Yasuhiko; Komoto, K; Tanaka, Shinji; Kajiyama, Goro

doi:10.1111/j.1572-0241.1998.00335.x

Cited by 120 publications

(57 citation statements)

References 24 publications

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“…It was proved that serum levels of pepsinogens reflect the morphological and functional status of the gastric mucosa. A low level of pepsinogen A or low ratio of pepsinogen A/pepsinogen C in serum was found to be markers for gastric cancer [9][10][11][12]. Determination of the content and mutual relationship of individual forms of human pepsins and their zymogens were found to be important from a diagnostic point of view [8,9,[13][14][15][16].…”

Section: Introductionmentioning

confidence: 93%

Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose

Frýdlová¹,

Kučerová²,

Tichá³

2008

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 93%

Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose

Frýdlová¹,

Kučerová²,

Tichá³

2008

Journal of Chromatography B

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“…As to the gender difference in gastritis and gastric cancer, several pieces evidences have been reported. We previously reported the gender differences in the background mucosa [14] and in the genetic pathway of gastric cancer [26]. Atrophy and intestinal metaplasia with H. pylori infection appears to be more severe in males than in females, and gender differences in mucosal responses to H. pylori infection cause male predominance in the incidence of intestinal-type gastric cancer [27].…”

Section: Discussionmentioning

confidence: 99%

“…The serum levels of pepsinogen (PG) I, PG II, and the anti- H. pylori IgG antibody (Eiken E-plate, Tokyo, Japan) were examined as we reported previously [14], and the serum gastrin level was also determined by radioimmunoassay. …”

Section: Methodsmentioning

confidence: 99%

Relationship between Helicobacter pylori Tyrosine-Phosphorylated CagA-Related Markers and the Development of Diffuse-Type Gastric Cancers: A Case-Control Study

Wada

Ito²,

Takata³

et al. 2010

Digestion

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Background/Aims: Tyrosine phosphorylation of the EPIYA motif in Helicobacter pylori CagA (CagA-P) plays an important role in toxic reaction. Diffuse-type gastric cancer (DGC) has a poor prognosis. We tried to clarify the expression level of CagA-P in DGC patients. Methods: We enrolled 42 early-stage DGC patients (DGC group; 20 males, 22 females, mean age 58.2 years) and 42 age- and gender-matched atrophic gastritis (AG) patients (AG group) as controls. We evaluated histological and serological gastritis and examined two markers; the serum titer of anti-CagA-P antibody and CagA-P expression in gastric mucosa. Results: In the DGC group, we found significantly higher corpus histological gastritis scores for activity, atrophy, and intestinal metaplasia. The titer of anti-CagA-P antibody and CagA-P expression in the corpus were significantly higher in the DGC group, especially in females (p < 0.05). Sixteen patients (38.1%) in the DGC group showed both positive markers, and the odds ratio for DGC occurrence was 4.00 (95% CI = 1.07–14.91), while that for females was 9.00 (95% CI = 1.29–62.97). Conclusions: CagA-P plays a role in active corpus gastritis, which may link to DGC carcinogenesis. Clinical quantification of CagA-P-related markers may be useful for the evaluation of DGC risk, especially in females.

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“…There are overwhelming epidemiological evidences supporting that serum level of PGI and/or PGI/II ratio correlates well with morphologic and functional changes of gastric mucosa [3-7]. Accordingly, they have been widely used as ‘serological biopsy’ for the screening of gastric cancer (GC) and its precancerous lesions [3-7].…”

Section: Introductionmentioning

confidence: 99%

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease

Sun

et al. 2013

BMC Clin Pathol

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BackgroundSerum pepsinogen (PG) I/II ratio has been widely used as “serological biopsy” for the screening of gastric cancer (GC) and atrophic gastritis (GA). However, study concerning in situ expression of PGs is currently insufficient, particularly for their relationship with serum PGs levels. This study was designed to investigate in situ expression of PGI and PGII in subjects with normal mucosa (NOR), superficial gastritis (GS), GA and GC, and to evaluate the correlations between PGs expressions in situ and in serum.Methods185 subjects were enrolled for the study, including 30 NOR, 70 GS, 54 GA and 31 GC. PGI and PGII expressions in situ and in serum were detected by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) respectively. H. pylori immunoglobulin (Ig) G was also determined by ELISA.ResultsIn situ expressions of PGI, PGII and PGI/II ratio consistently decreased in sequence of NOR/GS- > GA- > GC. The expressions of PGI, PGII and PGI/II ratio in situ were statistically higher in youngers than in olders (P < 0.05). In the NOR subjects, PGI staining was statistically higher in males than that in females (p = 0.02). For the correlations between in situ and serum expressions of PGI, PGII and PGI/II ratio, a borderline correlation in the total study sample (r = 0.131, P = 0.076) and a statistical correlation in GA cases (r = 0.307, P = 0.027) were observed for the PGI/II ratio. The PGI expression correlated well with that of PGII in situ and in serum.ConclusionsThe in situ levels of PGI, PGII and PGI/II ratio sharply decreased in the GA and GC cases. The youngers exhibited higher levels of PGI, PGII and PGI/II ratios than the olders. The in situ PGI/II ratio rather than PGI and PGII alone showed certain correlation with that in serum, and the PGI expression correlated well with PGII expression. Further studies with large-scale samples are still required to validate our findings.

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Correlation of Ratio of Serum Pepsinogen I and II With Prevalence of Gastric Cancer and Adenoma in Japanese Subjects

Abstract: Our study verified that a low I/II ratio signifies a high risk for GC and GA and that measuring serum PG levels can be used as a screening method for GC and GA.

Cited by 120 publications

References 24 publications

Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose

Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose

Relationship between Helicobacter pylori Tyrosine-Phosphorylated CagA-Related Markers and the Development of Diffuse-Type Gastric Cancers: A Case-Control Study

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease

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