Correlation of qEEG with PET in Schizophrenia

Abstract

PET relative metabolism was correlated with quantitative EEG in 9 schizophrenic patients. The PET metabolic regions of interest were the frontal lobes, thalamus and basal ganglia, and right and left temporal lobes. Significant positive correlations were seen for the frontal lobes and delta EEG power, and alpha power with subcortical metabolism. The physiologic plausibility of those correlations is discussed with reference to the possible effect of neuroleptic medication.

Cross-frequency coupling of brain oscillations: An impact of state anxiety

“…Indeed, studies using dipole modeling place the site of cortical delta generation in anterior medial frontal cortex (Michel et al, 1992(Michel et al, , 1993. Studies correlating positron emission tomography (PET) and EEG also indicate a positive correlation between waking delta and PET metabolism in the medial frontal cortex (Alper et al, 1995(Alper et al, , 1998(Alper et al, , 2006. Recently Wacker et al (2009) have shown that delta activity in the rostral anterior cingulate cortex correlates (negatively) with the nucleus accumbens responses to reward and is associated (positively) with anhedonia scores.…”

Persistent QEEG Abnormality in Crack Cocaine Users at 6 Months of Drug Abstinence

“…Studies utilizing dipole modeling (Michel et al 1992(Michel et al , 1993 and the correlation of positron emission tomography and the EEG (Alper et al , 1998 estimate the location of the major site of delta generation in midline and anterior frontal cortex, which corresponds with the location of the main cortical terminal field of the mesotelencephalic DA projection. Cortical layer V contains the pyramidal cells that are thought to generate the delta rhythm (McCormick 1992;Steriade et al 1990), as well as high density of DA teru e minals whose synaptic architecture and laminar distribution appear specifically adapted to the horizontal integration necessary to modulate the wide field, global delta rhythm (Berger 1994;Silberstein 1995).…”

EEG low-resolution brain electromagnetic tomography (LORETA) in Huntington’s disease

“…This is in line with our electrophysiological findings of an inhibited function of the OFC and ACC only in later stages of the disease. For the following reasons the previous interruption of the associative circuit may not become electrophysiologically significant over the DLPFC: According to Alper et al [67,86], the major site of delta generation is the OFC, which makes this region more sensitive to changes in delta power. Furthermore, progressive deterioration and interruption of the reciprocal interconnections between the basal ganglia and the frontal cortex together with localized atrophic degenerations [7,12], which are more prominent in later stages, may finally lead to the increase in delta power.…”