Correlation of plasma nitrite/nitrate levels and inducible nitric oxide gene expression among women with cervical abnormalities and cancer

Sowjanya, A. Pavani; Rao, Meera; Vedantham, Haripriya; Kalpana, Basany; Poli, Usha Rani; Marks, Morgan A.; Sujatha, M.

doi:10.1016/j.niox.2015.09.005

Cited by 17 publications

(10 citation statements)

References 36 publications

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“… 28 Deleterious metabolites such as nitrous acid can be produced by these organisms, and the risk of HPV infection also increases. 29 Persistent infection of oncogenic HPV is a cause of cervical cancer. 6 The abundance of Lactobacillus in HPV infection is lower, and HPV oncogenes may be involved in regulation of the viability of cervical cancer cells inhibited by Lactobacillus .…”

Section: Discussionmentioning

confidence: 99%

Role of <em>Lactobacillus</em> in cervical cancer

Yang¹,

Da²,

Zhang³

et al. 2018

CMAR

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Cervical cancer is a common malignant cancer among women worldwide. Changes in the vaginal microecological environment lead to multiple gynecological diseases, including cervical cancer. Recent research has shown that Lactobacillus may play an important role in the occurrence and development of cervical cancer. This review explores the role of Lactobacillus in cervical cancer. A total of 29 articles were included after identification and screening. The pertinent literature on Lactobacillus in cervical cancer from two perspectives, including clinical studies and experimental studies, was analyzed. An association network for the mechanism by which Lactobacillus induces cervical cancer was constructed. In addition, we provide direction and insight for further research on the role of Lactobacillus in cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Role of <em>Lactobacillus</em> in cervical cancer

Yang¹,

Da²,

Zhang³

et al. 2018

CMAR

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“…Gastric cancer is an example wherein a pathogen, Helicobacter pylori, directly elevates NOS2 (25). Cervical cancers associated with human papillomavirus infection also have elevated NOS2 (138). Interestingly, NOS2 has a positive prognostic effect at early stages of cervical cancer, but in later stages, NOS2 is a predictor of poor prognosis and leads to more vascularization and metastasis like in other solid cancers (43,138).…”

Section: Nos2 and Patient Outcomesmentioning

confidence: 99%

“…Cervical cancers associated with human papillomavirus infection also have elevated NOS2 (138). Interestingly, NOS2 has a positive prognostic effect at early stages of cervical cancer, but in later stages, NOS2 is a predictor of poor prognosis and leads to more vascularization and metastasis like in other solid cancers (43,138). An alternative route to NOS2 induction is the metabolic change in the tumor environment where increases in hypoxia lead to increased NOS2 expression, and these metabolic changes may be caused due to infection and inflammation (Fig.…”

Section: Nos2 and Patient Outcomesmentioning

confidence: 99%

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

Somasundaram

Basudhar

Bharadwaj

et al. 2019

Antioxidants & Redox Signaling

148

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“…It has been found that patients with high-grade squamous intraepithelial lesions or invasive lesions have higher levels of nitrite/nitrate in plasma and elevated expression of inducible NO synthase compared to normal subjects [ 76 ]. NO can be regarded as a marker of inflammation, being produced in epithelial cells and leucocytes under inflammatory conditions [ 77 ].…”

Section: The Link Between Inflammation Oxidative Stress and Hpv-mentioning

confidence: 99%

New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress

Georgescu

Mitran

et al. 2018

Journal of Immunology Research

106

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Human papillomavirus (HPV) is a small double-stranded DNA virus with tropism for epithelial cells. To this date, over 150 genotypes are known and are classified into two major groups, low-risk and high-risk strains, depending on the ability of the virus to induce malignant transformation. The host's immunity plays a central role in the course of the infection; therefore, it may not be clinically manifest or may produce various benign or malignant lesions. The pathogenic mechanisms are complex and incompletely elucidated. Recent research suggests the role of chronic inflammation and oxidative stress (OS) in the pathogenesis of HPV infection and the associated carcinogenic processes. Chronic inflammation induces OS, which in turn promotes the perpetuation of the inflammatory process resulting in the release of numerous molecules which cause cell damage. Reactive oxygen species exert a harmful effect on proteins, lipids, and nucleic acids. Viral oncogenes E5, E6, and E7 are involved in the development of chronic inflammation through various mechanisms. In addition, HPV may interfere with redox homeostasis of host cells, inducing OS which may be involved in the persistence of the infection and play a certain role in viral integration and promotion of carcinogenesis. Knowledge regarding the interplay between chronic inflammation and OS in the pathogenesis of HPV infection and HPV-induced carcinogenesis has important consequences on the development of new therapeutic strategies.

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Correlation of plasma nitrite/nitrate levels and inducible nitric oxide gene expression among women with cervical abnormalities and cancer

Cited by 17 publications

References 36 publications

Role of <em>Lactobacillus</em> in cervical cancer

Role of <em>Lactobacillus</em> in cervical cancer

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress

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